ChemicalBook > CAS DataBase List > 5-bromo-3-ethynylpyrazin-2-amine

5-bromo-3-ethynylpyrazin-2-amine

Product Name
5-bromo-3-ethynylpyrazin-2-amine
CAS No.
1209289-08-6
Chemical Name
5-bromo-3-ethynylpyrazin-2-amine
Synonyms
EOS-61574;5-bromo-3-ethynylpyrazin-2-amine;5-Bromo-3-ethynyl-2-pyrazinamine;2-Pyrazinamine, 5-bromo-3-ethynyl-;5-BroMo-3-ethynyl-pyrazin-2-ylaMine;2-Amino-5-bromo-3-ethynylpyrazine - [A42148]
CBNumber
CB62499710
Molecular Formula
C6H4BrN3
Formula Weight
198.02
MOL File
1209289-08-6.mol
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5-bromo-3-ethynylpyrazin-2-amine Property

Boiling point:
313.7±42.0 °C(Predicted)
Density 
1.80±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
0.92±0.10(Predicted)
Appearance
Light yellow to yellow Solid
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
A594420
Product name
2-Amino-5-bromo-3-ethynylpyrazine
Packaging
100mg
Price
$115
Updated
2021/12/16
Synthonix
Product number
A42148
Product name
2-Amino-5-bromo-3-ethynylpyrazine
Purity
98%
Packaging
1g
Price
$120
Updated
2021/12/16
Activate Scientific
Product number
AS30804
Product name
2-Amino-5-bromo-3-ethynylpyrazine
Purity
98+%
Packaging
1g
Price
$148
Updated
2021/12/16
Apolloscientific
Product number
OR904952
Product name
2-Amino-5-bromo-3-ethynylpyrazine
Packaging
100mg
Price
$169
Updated
2021/12/16
SynQuest Laboratories
Product number
3H30-9-2Q
Product name
2-Amino-5-bromo-3-ethynylpyrazine
Purity
95%
Packaging
100mg
Price
$200
Updated
2021/12/16
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5-bromo-3-ethynylpyrazin-2-amine Chemical Properties,Usage,Production

Synthesis

875781-41-2

1209289-08-6

Step 2: Synthesis of 5-bromo-3-ethynylpyrazin-2-amine A solution of 5-bromo-3-[(trimethylsilyl)alkynyl]pyrazin-2-amine (2.5 g, 9.25 mmol) and potassium carbonate (1.279 g, 9.25 mmol) in methanol (40 mL) was added to a 150 mL round-bottomed flask, and the reaction mixture was brown in color. The reaction was stirred at room temperature for 30 minutes. After completion of the reaction, the mixture was extracted with dichloromethane and the organic layer was washed sequentially with water and brine. The organic layer was separated, dried with anhydrous magnesium sulfate, filtered and the solvent was concentrated under reduced pressure to give a brown solid product (1.54 g). Product Characterization: LCMS: retention time 0.78 min, mass-to-charge ratio m/z 200.2 [M + H]+; analytical method: 2 min low pH method. 1H NMR (400 MHz, DMSO-d6) δ 8.12 (1H, s), 6.86 (2H, br s), 4.81 (1H, s).

References

[1] Patent: WO2015/162459, 2015, A1. Location in patent: Page/Page column 328

5-bromo-3-ethynylpyrazin-2-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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5-bromo-3-ethynylpyrazin-2-amine Suppliers

China 69 Germany 1 India 1 United Kingdom 1 United States 5 Global 77
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