5-BROMO-2-CHLORO-4-METHOXYPYRIDINE

Product Name: 5-BROMO-2-CHLORO-4-METHOXYPYRIDINE
CAS No.: 880870-13-3
Chemical Name: 5-BROMO-2-CHLORO-4-METHOXYPYRIDINE
Synonyms: 5-BROMO-2-CHLORO-4-METHOXYPYRIDINE;2-chloro-4-methoxy-5-bromopyridine;Pyridine, 5-bromo-2-chloro-4-methoxy-
CBNumber: CB52452868
Molecular Formula: C6H5BrClNO
Formula Weight: 222.47
MOL File: 880870-13-3.mol

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5-BROMO-2-CHLORO-4-METHOXYPYRIDINE Property

Boiling point:: 251℃
Density: 1.650
Flash point:: 105℃
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -0.14±0.10(Predicted)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: B673823
Product name: 5-bromo-2-chloro-4-methoxypyridine
Packaging: 100mg
Price: $90
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB143754
Product name: 5-Bromo-2-chloro-4-methoxypyridine
Packaging: 100mg
Price: $79
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: B15676
Product name: 5-Bromo-2-chloro-4-methoxypyridine
Purity: 98%
Packaging: 1g
Price: $140
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB143754
Product name: 5-Bromo-2-chloro-4-methoxypyridine
Packaging: 250mg
Price: $157.5
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB143754
Product name: 5-Bromo-2-chloro-4-methoxypyridine
Packaging: 500mg
Price: $275
Updated: 2021/12/16

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5-BROMO-2-CHLORO-4-METHOXYPYRIDINE Chemical Properties,Usage,Production

Synthesis

17228-69-2

880870-13-3

2-Chloro-4-methoxypyridine (13.3 g, 92.6 mmol) was used as starting material and dissolved in concentrated sulfuric acid (65 mL). N-bromosuccinimide (16.5 g, 92.6 mmol) was added to the solution in batches under ice bath cooling conditions. Subsequently, the reaction mixture was stirred at 0 °C and gradually warmed up to 55 °C and kept at this temperature for 3 hours. After completion of the reaction, the mixture was slowly poured into ice water and the pH was adjusted to alkaline with 8N aqueous sodium hydroxide solution. Extraction was carried out with chloroform and the combined organic phases were washed with saturated brine and dried with anhydrous sodium sulfate. After filtration to remove the desiccant, the filtrate was concentrated under reduced pressure. The resulting crude product was purified by silica gel column chromatography with an eluent ratio of hexane:ethyl acetate (9:1 to 5:1) to afford 5-bromo-2-chloro-4-methoxypyridine as a white solid (9.3 g, 45% yield). The structure of the product was confirmed by 1H NMR (CDCl3, 300 MHz) with the following chemical shifts (δ): 3.97 (3H, s, OCH3), 6.84 (1H, s, pyridine ring H), 8.34 (1H, s, pyridine ring H).

References

[1] Patent: US2006/84665, 2006, A1. Location in patent: Page/Page column 49
[2] Patent: WO2010/129379, 2010, A1. Location in patent: Page/Page column 85
[3] Patent: WO2013/66714, 2013, A1. Location in patent: Page/Page column 42; 43
[4] Patent: WO2013/66718, 2013, A2. Location in patent: Page/Page column 28-29
[5] Patent: WO2015/17305, 2015, A1. Location in patent: Page/Page column 59

5-BROMO-2-CHLORO-4-METHOXYPYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-BROMO-2-CHLORO-4-METHOXYPYRIDINE Suppliers

China 87 India 1 United Kingdom 1 United States 6 Global 95

Shijiazhuang Sdyano Fine Chemical Co., Ltd.

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Tel: +86-021-50890968，021-50891159 +86-18601776121
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SuZhou ShiYa Biopharmaceuticals, Inc.

Tel: 0512-0512-52358471 17715136450
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Nanjing Vital Chemical Co., Ltd.

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View Lastest Price from 5-BROMO-2-CHLORO-4-METHOXYPYRIDINE manufacturers

Career Henan Chemical Co

Product: 5-BROMO-2-CHLORO-4-METHOXYPYRIDINE 880870-13-3
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2019-12-31

880870-13-3, 5-BROMO-2-CHLORO-4-METHOXYPYRIDINERelated Search:

Trimethoprim 5-Bromo-2-ethoxypyridin-3-amine 5-BroMo-2-(diMethylaMino)benzaldehyde 5-broMo-1-MethylpyriMidin-2-one 5-broMo-4,4-diMethyl-1,2,3,4-tetrahydroisoquinoline 5-bromo-3-ethynylpyrazin-2-amine 5-bromo-2-methylpyrimidin-4-ol 5-BROMO-3-CHLORO-2-HYDROXYPYRIDINE 5-bromo-3-phenyl-1,2,4-oxadiazole 5-bromo-2-methoxy-3-(trifluoromethyl)pyridine 5-Bromo-1-methyl-1H-pyrrole-2-carboxylicacid 3-BROMO-4-METHOXY-PYRIDINE 5-BROMO-2-CHLORO-4-METHOXYPYRIDINE 5-BROMO-2-CHLORO-4-FLUORO-PHENOL 5-BROMO-2-CHLORO-3-IODO-PYRIDINE 5-Bromo-2-methoxypyridine 5-BroMo-2-chloro-4-fluoropyridine

5-BROMO-2-CHLORO-4-METHOXYPYRIDINE

Pyridine, 5-bromo-2-chloro-4-methoxy-

2-chloro-4-methoxy-5-bromopyridine

880870-13-3