5-bromo-2-methoxy-3-(trifluoromethyl)pyridine

Product Name: 5-bromo-2-methoxy-3-(trifluoromethyl)pyridine
CAS No.: 1214377-42-0
Chemical Name: 5-bromo-2-methoxy-3-(trifluoromethyl)pyridine
Synonyms: 5-bromo-2-methoxy-3-(triflu;2-Methoxy-3-trifluoromethyl-5-bromopyridine;5-broMo-3-(trifluoroMethyl)-2-Methoxypyridine;5-bromo-2-methoxy-3-(trifluoromethyl)pyridine;Pyridine, 5-bromo-2-methoxy-3-(trifluoromethyl)-;5-bromo-2-methoxy-3-(trifluoromethyl)pyridine ISO 9001：2015 REACH
CBNumber: CB02500898
Molecular Formula: C7H5BrF3NO
Formula Weight: 256.02
MOL File: 1214377-42-0.mol

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5-bromo-2-methoxy-3-(trifluoromethyl)pyridine Property

Boiling point:: 208.0±40.0 °C(Predicted)
Density: 1.637±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -1.38±0.20(Predicted)
form: liquid
color: Clear, colourless
InChI: InChI=1S/C7H5BrF3NO/c1-13-6-5(7(9,10)11)2-4(8)3-12-6/h2-3H,1H3
InChIKey: ZIOFHXRZJCIBCO-UHFFFAOYSA-N
SMILES: C1(OC)=NC=C(Br)C=C1C(F)(F)F

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: B696935
Product name: 5-Bromo-2-methoxy-3-(trifluoromethyl)pyridine
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B696935
Product name: 5-Bromo-2-methoxy-3-(trifluoromethyl)pyridine
Packaging: 500mg
Price: $65
Updated: 2021/12/16

Matrix Scientific

Product number: 075420
Product name: 5-Bromo-2-methoxy-3-(trifluoromethyl)pyridine
Purity: 95+%
Packaging: 1g
Price: $24
Updated: 2021/12/16

Apolloscientific

Product number: PC49527
Product name: 5-Bromo-2-methoxy-3-(trifluoromethyl)pyridine
Packaging: 1g
Price: $24
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H07-B-X2
Product name: 5-Bromo-2-methoxy-3-(trifluoromethyl)pyridine
Packaging: 1g
Price: $39
Updated: 2021/12/16

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5-bromo-2-methoxy-3-(trifluoromethyl)pyridine Chemical Properties,Usage,Production

Synthesis

121643-44-5

1214377-42-0

General procedure for the synthesis of 2-methoxy-3-trifluoromethyl-5-bromopyridine from 2-methoxy-3-trifluoromethylpyridine: 1. Trifluoroacetic acid (TFA, 80 mL) was added to a mixture of 2-methoxy-3-trifluoromethylpyridine (20.0 g, 113.0 mmol) and 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione (43.6 g, 152.0 mmol), and stirred for 18 hours at room temperature under argon protection. 2. Upon completion of the reaction, the TFA was removed by distillation under reduced pressure at 50 mbar and 45 °C. The residue was suspended in tert-butyl methyl ether (200 mL), filtered to remove the resulting colorless solid, and washed with tert-butyl methyl ether (50 mL). 3. The filtrate was concentrated under reduced pressure and suspended in ethyl acetate (EtOAc, 50 mL), filtered again to remove the insoluble colorless solid, and washed with ethyl acetate (50 mL). 4. The filtrate was concentrated under reduced pressure, diluted with heptane/tert-butyl methyl ether (5:1, 20 mL), and filtered to remove the insoluble colorless solid. 5. The filtrate was purified by silica gel column chromatography with heptane/ethyl acetate (100/0 to 90/10) as eluent. 6. The crude product was filtered through a plug of sodium bicarbonate (NaHCO3, 20 g) and the filtrate was evaporated under reduced pressure to give a golden yellow oil (27.9 g). 7. The oily substance was dissolved in heptane (20 mL), purified by filtration through a plug of silica gel (80 g), and eluted with heptane to afford 5-bromo-2-methoxy-3-trifluoromethylpyridine as a colorless oil (22.5 g, 74% yield). 1H-NMR (400MHz, DMSO-d6, 298K): δ 4.03 (s, 3H), 7.95 (d, 1H), 8.4 (d, 1H).

References

[1] Patent: WO2012/4299, 2012, A1. Location in patent: Page/Page column 66-67
[2] Patent: WO2013/1445, 2013, A1. Location in patent: Page/Page column 37
[3] Patent: WO2013/88404, 2013, A1. Location in patent: Page/Page column 73; 74
[4] Patent: US2015/342951, 2015, A1. Location in patent: Paragraph 0806
[5] Patent: WO2013/57711, 2013, A1. Location in patent: Page/Page column 45

5-bromo-2-methoxy-3-(trifluoromethyl)pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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5-bromo-2-methoxy-3-(trifluoromethyl)pyridine Suppliers

China 142 India 1 United Kingdom 1 United States 14 Global 158

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View Lastest Price from 5-bromo-2-methoxy-3-(trifluoromethyl)pyridine manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd

Product: 5-Bromo-2-methoxy-3-(trifluoromethyl)pyridine 1214377-42-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: Customise
Release date: 2025-11-28

Shaanxi Dideu New Materials Co. Ltd

Product: 5-bromo-2-methoxy-3-(trifluoromethyl)pyridine 1214377-42-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2024-11-08

Pharmahands (Taizhou) Co., Ltd.

Product: 5-bromo-2-methoxy-3-(trifluoromethyl)pyridine 1214377-42-0
Price: US $5300.00/Kg/Drum
Min. Order: 10g
Purity: 99%
Supply Ability: 20kg
Release date: 2020-09-09

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