2-Amino-1,3,4-thiadiazole

Product Name: 2-Amino-1,3,4-thiadiazole
CAS No.: 4005-51-0
Chemical Name: 2-Amino-1,3,4-thiadiazole
Synonyms: 1,3,4-THIADIAZOL-2-AMINE;X 26;tf128;TF 128;nsc4728;FDA 0084;NSC 4728;2-AMino-1;AKOS AU36-M92;aminothiadazole
CBNumber: CB6264682
Molecular Formula: C2H3N3S
Formula Weight: 101.13
MOL File: 4005-51-0.mol

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2-Amino-1,3,4-thiadiazole Property

Melting point:: 188-191 °C (dec.) (lit.)
Boiling point:: 238.9±23.0 °C(Predicted)
Density: 1.385 (estimate)
refractive index: 1.5800 (estimate)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: water: soluble25mg/mL, clear, colorless
form: Crystals or Crystalline Powder
pka: pKa 3.2 (Uncertain)
color: White to light yellow
Water Solubility: It is soluble in water, hot methanol- very faint turbidity.
BRN: 107135
InChIKey: QUKGLNCXGVWCJX-UHFFFAOYSA-N
CAS DataBase Reference: 4005-51-0(CAS DataBase Reference)
NIST Chemistry Reference: 2-Amino-1,3,4-thiadiazole(4005-51-0)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 68-63-36/37/38-20/21/22-22
Safety Statements: 36/37/39-26-36
RIDADR: 2811
WGK Germany: 3
RTECS: XI3000000
Hazard Note: Harmful
HazardClass: 6.1
PackingGroup: III
HS Code: 29349990
Toxicity: LD50 oral in rat: 253mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 258881
Product name: 2-Amino-1,3,4-thiadiazole
Purity: 97%
Packaging: 5g
Price: $40.7
Updated: 2025/07/31

TCI Chemical

Product number: A1060
Product name: 2-Amino-1,3,4-thiadiazole
Purity: >98.0%(T)
Packaging: 5g
Price: $19
Updated: 2025/07/31

TCI Chemical

Product number: A1060
Product name: 2-Amino-1,3,4-thiadiazole
Purity: >98.0%(T)
Packaging: 25g
Price: $44
Updated: 2025/07/31

TRC

Product number: A630315
Product name: 2-Amino-1,3,4-thiadiazole
Packaging: 5g
Price: $50
Updated: 2021/12/16

Usbiological

Product number: 414902
Product name: 2-Amino-1-
Packaging: 250mg
Price: $382
Updated: 2021/12/16

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2-Amino-1,3,4-thiadiazole Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powde

Uses

A thiadiazole derivative with fungacidal properties. An antitumor agent.

Uses

2-Amino-1,3,4-thiadiazole, is used as an intermediate for ceftraoline.

General Description

2-Amino-1,3,4-thiadiazole (donor) form charge transfer complexes with 2,3-dichloro-5,6-dicyano-p-benzoquinone, p-chloranil, o-chloranil, p-bromanil and chloranilic acid (acceptors). Effects of 2-amino-1,3,4-thiadiazole [aminothiadiazole (NSC 4728)] on purine and pyrimidine ribonucleotide pools of L1210 ascites cells in vivo has been reported.

Safety Profile

Poison by subcutaneous andintraperitoneal routes. An experimental teratogen. Otherexperimental reproductive effects. When heated todecomposition it emits very toxic fumes of NOx and SOx.

Synthesis

64-18-6

79-19-6

4005-51-0

General procedure for the synthesis of 2-amino-1,3,4-thiadiazole from formic acid and aminothiourea: 5.00 g of aminothiourea was accurately weighed and placed in a 50 mL three-necked flask fitted with a stirring magnet, and 5.00 mL of formic acid was added at once. The reaction was stirred under the condition of cooling in an ice bath, and after the formation of a slurry, 6.00 mL of concentrated hydrochloric acid was added slowly and dropwise. After the dropwise addition, the reaction mixture was transferred to an oil bath preheated to 107 °C with stirring turned on and the reaction was carried out for 4.5 to 5.0 h. During this time, the reaction progress was monitored by thin-layer chromatography (TLC), and the reaction was stopped when the raw material point disappeared. After the reaction solution was cooled to room temperature, the pH was adjusted with concentrated ammonia to 8-9. The mixture was placed in a refrigerator overnight, white crystals were precipitated, filtered, washed three times with ice water, and finally recrystallized with distilled water to give 4.96 g of white crystal product in about 90% yield. The melting point of the product was 198 to 201 °C. The resulting product was confirmed to be 2-amino-1,3,4-thiadiazole by infrared spectroscopy (IR), nuclear magnetic resonance (NMR) and mass spectrometry (MS) analysis.

References

[1] Nature Communications, 2017, vol. 8, # 1,
[2] Journal of Chemical Research, 2005, # 5, p. 341 - 343
[3] Journal of the Chemical Society of Pakistan, 2015, vol. 37, # 1, p. 115 - 121
[4] Patent: CN106117268, 2016, A. Location in patent: Paragraph 0030; 0031
[5] Patent: CN106167502, 2016, A. Location in patent: Paragraph 0032; 0033

2-Amino-1,3,4-thiadiazole Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Amino-1,3,4-thiadiazole Suppliers

Americas 1 Belgium 2 Canada 3 China 272 Europe 6 France 1 Germany 6 Hungary 1 India 5 Japan 3 Russia 1 Slovakia 1 South Korea 1 Switzerland 2 Ukraine 1 United Kingdom 16 United States 31 Global 353

Toronto Research Chemicals

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Elkimia, Inc.

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View Lastest Price from 2-Amino-1,3,4-thiadiazole manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 2-Amino-1,3,4-thiadiazole 4005-51-0
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 99%min
Supply Ability: 1000kgs
Release date: 2021-08-26

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2-Amino-1,3,4-thiadiazole 4005-51-0
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-28

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 2-Amino-1,3,4-thiadiazole 4005-51-0
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 ton
Release date: 2024-12-19

4005-51-0, 2-Amino-1,3,4-thiadiazoleRelated Search:

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2-AMINO-1,3,4-THIADIAZOLE

FDA 0084

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TF 128

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LABOTEST-BB LT00019802

TIMTEC-BB SBB010052

AKOS AU36-M92

2-Amino-1,3,4-thiadiazole, HPLC 97%

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4005-51-0

AMINO

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bc0001