ML 133 Hydrochloride
- Product Name
- ML 133 Hydrochloride
- CAS No.
- 1222781-70-5
- Chemical Name
- ML 133 Hydrochloride
- Synonyms
- ML133 HCl;ML 133 Hydrochloride;CID 781301 hydrochloride;VU0404943-1 hydrchloride;SID 85281105 hydrochloride;ML 133 Hydrochloride USP/EP/BP;(4-Methoxybenzyl)(1-naphthylMethyl)aMine Hydrochloride;N-(4-methoxybenzyl)-1-(naphthalen-1-yl)methanamine hydrochloride;N-[(4-METHOXYPHENYL)METHYL]-1-NAPHTHALENEMETHANAMINE HYDROCHLORIDE;(4-methoxyphenyl)-N-(naphthalen-1-ylmethyl)methanamine hydrochloride
- CBNumber
- CB62653895
- Molecular Formula
- C19H20ClNO
- Formula Weight
- 313.83
- MOL File
- 1222781-70-5.mol
ML 133 Hydrochloride Property
- Melting point:
- 193-195°C
- storage temp.
- 2-8°C
- solubility
- DMSO: ≥10mg/mL
- form
- powder
- color
- white to tan
Safety
- Hazard Codes
- Xn,N
- Risk Statements
- 22-37/38-41-50/53
- Safety Statements
- 26-39-60-61
- RIDADR
- UN 3077 9 / PGIII
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
H400Very toxic to aquatic life
- Precautionary statements
-
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- SML0190
- Product name
- ML133 hydrochloride
- Purity
- ≥95% (HPLC)
- Packaging
- 5mg
- Price
- $131
- Updated
- 2024/03/01
- Product number
- SML0190
- Product name
- ML133 hydrochloride
- Purity
- ≥95% (HPLC)
- Packaging
- 25mg
- Price
- $505
- Updated
- 2024/03/01
- Product number
- 4549
- Product name
- ML133 hydrochloride
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $675
- Updated
- 2021/12/16
- Product number
- M425075
- Product name
- ML133 hydrochloride
- Packaging
- 250mg
- Price
- $1120
- Updated
- 2021/12/16
- Product number
- 255843
- Product name
- ML 133 hydrochloride
- Packaging
- 10mg
- Price
- $403
- Updated
- 2021/12/16
ML 133 Hydrochloride Chemical Properties,Usage,Production
Uses
ML 133 is a selective inhibitor of inwardly rectifying Kir2.x potassium channels. ML 133 exhibits no effect on rKir1.1.
Uses
ML133 hydrochloride has been used as a Kir2.1 blocker to study the regulation of membrane excitability by inward-rectifier potassium channels (Kir2 family) in the dentate gyrus (DG) granule cells. It has also been used to study the effect of Kir2 on cortical neural activity.
Biological Activity
ml133 is a selective potassium channel inhibitor for kir2.1 with ic50 of 1.8 μm (ph 7.4) and 290 nm (ph 8.5), has no effect on kir1.1 and weak activity for kir4.1 and kir7.1.
Biochem/physiol Actions
ML133 hydrochloride is a selective inhibitor of the Kir2 family of inward rectifier (IRK, KCNJ) potassium channels. ML133 inhibits Kir2.1 with IC50 of 1.8 μM at pH 7.4 and 290 nM at pH8.5. It exhibits little selectivity against other members of Kir2.x family channels, but has no effect on Kir1.1 (IC50 > 300 μM), and displays weak activity for Kir4.1 (76 μM) and Kir7.1 (33 μM), making ML133 the most selective small molecule inhibitor of the Kir family reported to date. It also showed modest selectivity versus hERG and a larger panel of GPCRs, ion channels and transporters.
storage
Store at +4°C