ML 133 Hydrochloride

ChemicalBook > CAS DataBase List > ML 133 Hydrochloride

Product Name: ML 133 Hydrochloride
CAS No.: 1222781-70-5
Chemical Name: ML 133 Hydrochloride
Synonyms: ML133 HCl;ML 133 Hydrochloride;CID 781301 hydrochloride;VU0404943-1 hydrchloride;SID 85281105 hydrochloride;ML 133 Hydrochloride USP/EP/BP;(4-Methoxybenzyl)(1-naphthylMethyl)aMine Hydrochloride;N-(4-methoxybenzyl)-1-(naphthalen-1-yl)methanamine hydrochloride;N-[(4-METHOXYPHENYL)METHYL]-1-NAPHTHALENEMETHANAMINE HYDROCHLORIDE;(4-methoxyphenyl)-N-(naphthalen-1-ylmethyl)methanamine hydrochloride
CBNumber: CB62653895
Molecular Formula: C19H20ClNO
Formula Weight: 313.83
MOL File: 1222781-70-5.mol

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ML 133 Hydrochloride Property

Melting point:: 193-195°C
storage temp.: 2-8°C
solubility: DMSO: ≥10mg/mL
form: powder
color: white to tan

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Safety

Hazard Codes: Xn,N
Risk Statements: 22-37/38-41-50/53
Safety Statements: 26-39-60-61
RIDADR: UN 3077 9 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0190
Product name: ML133 hydrochloride
Purity: ≥95% (HPLC)
Packaging: 5mg
Price: $131
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0190
Product name: ML133 hydrochloride
Purity: ≥95% (HPLC)
Packaging: 25mg
Price: $505
Updated: 2024/03/01

Tocris

Product number: 4549
Product name: ML133 hydrochloride
Purity: ≥99%(HPLC)
Packaging: 50
Price: $675
Updated: 2021/12/16

TRC

Product number: M425075
Product name: ML133 hydrochloride
Packaging: 250mg
Price: $1120
Updated: 2021/12/16

Usbiological

Product number: 255843
Product name: ML 133 hydrochloride
Packaging: 10mg
Price: $403
Updated: 2021/12/16

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ML 133 Hydrochloride Chemical Properties,Usage,Production

Uses

ML 133 is a selective inhibitor of inwardly rectifying Kir2.x potassium channels. ML 133 exhibits no effect on rKir1.1.

Uses

ML133 hydrochloride has been used as a Kir2.1 blocker to study the regulation of membrane excitability by inward-rectifier potassium channels (Kir2 family) in the dentate gyrus (DG) granule cells. It has also been used to study the effect of Kir2 on cortical neural activity.

Biological Activity

ml133 is a selective potassium channel inhibitor for kir2.1 with ic50 of 1.8 μm (ph 7.4) and 290 nm (ph 8.5), has no effect on kir1.1 and weak activity for kir4.1 and kir7.1.

Biochem/physiol Actions

ML133 hydrochloride is a selective inhibitor of the Kir2 family of inward rectifier (IRK, KCNJ) potassium channels. ML133 inhibits Kir2.1 with IC50 of 1.8 μM at pH 7.4 and 290 nM at pH8.5. It exhibits little selectivity against other members of Kir2.x family channels, but has no effect on Kir1.1 (IC50 > 300 μM), and displays weak activity for Kir4.1 (76 μM) and Kir7.1 (33 μM), making ML133 the most selective small molecule inhibitor of the Kir family reported to date. It also showed modest selectivity versus hERG and a larger panel of GPCRs, ion channels and transporters.

storage

Store at +4°C

ML 133 Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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ML 133 Hydrochloride Suppliers

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1222781-70-5

C19H19NOHCl

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