ChemicalBook > CAS DataBase List > ML 133 Hydrochloride

ML 133 Hydrochloride

Product Name
ML 133 Hydrochloride
CAS No.
1222781-70-5
Chemical Name
ML 133 Hydrochloride
Synonyms
ML133 HCl;ML 133 Hydrochloride;CID 781301 hydrochloride;VU0404943-1 hydrchloride;SID 85281105 hydrochloride;ML 133 Hydrochloride USP/EP/BP;(4-Methoxybenzyl)(1-naphthylMethyl)aMine Hydrochloride;N-(4-methoxybenzyl)-1-(naphthalen-1-yl)methanamine hydrochloride;N-[(4-METHOXYPHENYL)METHYL]-1-NAPHTHALENEMETHANAMINE HYDROCHLORIDE;(4-methoxyphenyl)-N-(naphthalen-1-ylmethyl)methanamine hydrochloride
CBNumber
CB62653895
Molecular Formula
C19H20ClNO
Formula Weight
313.83
MOL File
1222781-70-5.mol
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ML 133 Hydrochloride Property

Melting point:
193-195°C
storage temp. 
2-8°C
solubility 
DMSO: ≥10mg/mL
form 
powder
color 
white to tan
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Safety

Hazard Codes 
Xn,N
Risk Statements 
22-37/38-41-50/53
Safety Statements 
26-39-60-61
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0190
Product name
ML133 hydrochloride
Purity
≥95% (HPLC)
Packaging
5mg
Price
$131
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0190
Product name
ML133 hydrochloride
Purity
≥95% (HPLC)
Packaging
25mg
Price
$505
Updated
2024/03/01
Tocris
Product number
4549
Product name
ML133 hydrochloride
Purity
≥99%(HPLC)
Packaging
50
Price
$675
Updated
2021/12/16
TRC
Product number
M425075
Product name
ML133 hydrochloride
Packaging
250mg
Price
$1120
Updated
2021/12/16
Usbiological
Product number
255843
Product name
ML 133 hydrochloride
Packaging
10mg
Price
$403
Updated
2021/12/16
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ML 133 Hydrochloride Chemical Properties,Usage,Production

Uses

ML 133 is a selective inhibitor of inwardly rectifying Kir2.x potassium channels. ML 133 exhibits no effect on rKir1.1.

Uses

ML133 hydrochloride has been used as a Kir2.1 blocker to study the regulation of membrane excitability by inward-rectifier potassium channels (Kir2 family) in the dentate gyrus (DG) granule cells. It has also been used to study the effect of Kir2 on cortical neural activity.

Biological Activity

ml133 is a selective potassium channel inhibitor for kir2.1 with ic50 of 1.8 μm (ph 7.4) and 290 nm (ph 8.5), has no effect on kir1.1 and weak activity for kir4.1 and kir7.1.

Biochem/physiol Actions

ML133 hydrochloride is a selective inhibitor of the Kir2 family of inward rectifier (IRK, KCNJ) potassium channels. ML133 inhibits Kir2.1 with IC50 of 1.8 μM at pH 7.4 and 290 nM at pH8.5. It exhibits little selectivity against other members of Kir2.x family channels, but has no effect on Kir1.1 (IC50 > 300 μM), and displays weak activity for Kir4.1 (76 μM) and Kir7.1 (33 μM), making ML133 the most selective small molecule inhibitor of the Kir family reported to date. It also showed modest selectivity versus hERG and a larger panel of GPCRs, ion channels and transporters.

storage

Store at +4°C

ML 133 Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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ML 133 Hydrochloride Suppliers

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1222781-70-5, ML 133 HydrochlorideRelated Search:

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