N-Chlorophthalimide
- Product Name
- N-Chlorophthalimide
- CAS No.
- 3481-09-2
- Chemical Name
- N-Chlorophthalimide
- Synonyms
- ncp;2-Chloroisoindoline-1,3-dione;Chlorophtalimide;N-Chlorphthalimid;N-CHLOROPHTHALIMIDE;phthalimide chloride;Phthalimidoyl chloride;N-Chlorophthalimide,95%;N-Chlorophthalimide 96%;N-Chlorophthalimide
- CBNumber
- CB6265755
- Molecular Formula
- C8H4ClNO2
- Formula Weight
- 181.58
- MOL File
- 3481-09-2.mol
N-Chlorophthalimide Property
- Melting point:
- 188-198 °C (lit.)
- Boiling point:
- 315.1±25.0 °C(Predicted)
- Density
- 1.56±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- powder to crystal
- pka
- -3.53±0.20(Predicted)
- color
- White to Almost white
- InChI
- InChI=1S/C8H4ClNO2/c9-10-7(11)5-3-1-2-4-6(5)8(10)12/h1-4H
- InChIKey
- WDRFYIPWHMGQPN-UHFFFAOYSA-N
- SMILES
- C1(=O)C2=C(C=CC=C2)C(=O)N1Cl
- CAS DataBase Reference
- 3481-09-2(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 528218
- Product name
- N-Chlorophthalimide
- Purity
- 96%
- Packaging
- 25g
- Price
- $106
- Updated
- 2025/07/31
- Product number
- C0802
- Product name
- N-Chlorophthalimide
- Purity
- >95.0%(T)
- Packaging
- 25g
- Price
- $48
- Updated
- 2025/07/31
- Product number
- C0802
- Product name
- N-Chlorophthalimide
- Purity
- >95.0%(T)
- Packaging
- 500g
- Price
- $285
- Updated
- 2025/07/31
- Product number
- N926098
- Product name
- N-Chlorophthalimide
- Packaging
- 500mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 37232
- Product name
- N-Chlorophthalimide,95%(HPLC)
- Purity
- 95%(HPLC)
- Packaging
- 100G
- Price
- $78.4
- Updated
- 2021/12/16
N-Chlorophthalimide Chemical Properties,Usage,Production
Chemical Properties
White to pale yellow powder
Uses
N-Chlorophthalimide may be employed in the synthesis of:
- α-amino acetal
- α-amino nitro compounds
- vicinal diamine
- α,β-unsaturated vicinal haloamino nitro compound
General Description
N-Chlorophthalimide in anhydrous acetic acid serves as a useful oxidizing reagent for use in various direct titrimetric analyses. N-Chlorophthalimide can be synthesized by reacting phthalimide, t-butyl hypochlorite, water and t-butyl alcohol. It participates in the synthesis of 2-amino-3-benzoyl-α-(methylthio)phenylacetamide.
Synthesis
136918-14-4
3481-09-2
General procedure for the synthesis of N-chlorophthalimide from 3-hydroxy-1H-isoindol-1-one: Anhydrous aluminum trichloride (AlCl3, 1 eq., 10 mmol, 1.36 g) was added to an anhydrous acetonitrile (CH3CN, 100 mL) solution of lead tetraacetate (Pb(OAc)4, 1 eq., 10 mmol, 4.52 g). The mixture was stirred at room temperature for 5 minutes before phthalimide (1 eq., 10 mmol, 1.5 g) was added. The resulting mixture was gently refluxed under nitrogen protection for 20 h and subsequently cooled to room temperature. The solvent was removed by rotary evaporation and the crude product was purified by column chromatography using pure dichloromethane (DCM) as eluent. Yield: 1.32 g, 71% yield.1H NMR (300 MHz, CDCl3): δ 7.94-7.91 (m, 2H), 7.82-7.79 (m, 2H) ppm.
References
[1] Synthesis, 2009, # 16, p. 2797 - 2801
[2] Synlett, 2006, # 2, p. 194 - 200
[3] Catalysis Today, 2018, vol. 308, p. 94 - 101
[4] Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 6, p. 1302
[5] Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 8, p. 163
N-Chlorophthalimide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from N-Chlorophthalimide manufacturers
- Product
- N-Chlorophthalimide 3481-09-2
- Price
- US $30.00-10.00/kg
- Min. Order
- 10kg
- Purity
- 99%
- Supply Ability
- 100000kg
- Release date
- 2024-08-23
- Product
- N-Chlorophthalimide 3481-09-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 20T
- Release date
- 2024-07-10