5-Bromo-2-hydroxybenzyl alcohol

Product Name: 5-Bromo-2-hydroxybenzyl alcohol
CAS No.: 2316-64-5
Chemical Name: 5-Bromo-2-hydroxybenzyl alcohol
Synonyms: BROMOSALIGENIN;5-BROMOSALIGENIN;RARECHEM AL BD 0040;5-BROMOSALICYL ALCOHOL;2-HYDROXYMETHYL-4-BROMOPHENOL;4-BROMO-2-HYDROXYMETHYLPHENOL;5-BROMO-2-HYDROXYBENZYL ALCOHOL;5-Bromo-2-hydroxybenzenemethanol;5-BROMO-2-HYDROXYBENZYL ALCOHOL 98%;5-Bromo-2-hydroxybenzyl Alcohol >
CBNumber: CB6268796
Molecular Formula: C7H7BrO2
Formula Weight: 203.03
MOL File: 2316-64-5.mol

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5-Bromo-2-hydroxybenzyl alcohol Property

Melting point:: 110-112 °C (lit.)
Boiling point:: 281.8±10.0 °C(Predicted)
Density: 1.5178 (rough estimate)
refractive index: 1.4620 (estimate)
storage temp.: Inert atmosphere,Room Temperature
solubility: water: soluble0.7% at 25°C(lit.)
form: Crystalline Powder or Flakes
pka: 9.36±0.18(Predicted)
color: White to light brown
Water Solubility: water: soluble 0.7% at25°C(lit.)
olive oil: soluble 4.8%(lit.)
alcohol: freely soluble(lit.)
benzene: moderately soluble(lit.)
chloroform: moderately soluble(lit.)
diethyl ether: freely soluble(lit.)
ethyl acetate: freely soluble(lit.)
hot water: soluble(lit.)
BRN: 509726
InChIKey: KNKRHSVKIORZQB-UHFFFAOYSA-N
CAS DataBase Reference: 2316-64-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39-24/25
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29081990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 197009
Product name: 5-Bromo-2-hydroxybenzyl alcohol
Purity: ≥98%
Packaging: 5g
Price: $163
Updated: 2025/07/31

TCI Chemical

Product number: B2164
Product name: 5-Bromo-2-hydroxybenzyl Alcohol
Purity: >98.0%(GC)
Packaging: 1g
Price: $24
Updated: 2025/07/31

TCI Chemical

Product number: B2164
Product name: 5-Bromo-2-hydroxybenzyl Alcohol
Purity: >98.0%(GC)
Packaging: 5g
Price: $69
Updated: 2025/07/31

TRC

Product number: B696165
Product name: 5-Bromo-2-hydroxybenzyl Alcohol
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B696165
Product name: 5-Bromo-2-hydroxybenzyl Alcohol
Packaging: 500mg
Price: $65
Updated: 2021/12/16

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5-Bromo-2-hydroxybenzyl alcohol Chemical Properties,Usage,Production

Chemical Properties

white to light brown crystalline powder or flakes

Uses

5-Bromo-2-hydroxybenzyl alcohol was used in the synthesis of:

7-bromo-2,3-diphenyl-5H-imidazo[2,1-b][1,3]benzoxazine
6-bromo-2-octyl-4H-1,3,2-benzodioxaphosphorin 2-oxide
4-bromo-2-(5-iodo-1H-indol-3-ylmethyl)- phenol

Synthesis

1761-61-1

2316-64-5

The general procedure for the synthesis of 5-bromo-2-hydroxybenzenemethanol from 5-bromosalicylaldehyde was as follows: according to the improved synthetic method reported in the literature, 5-bromo-2-hydroxybenzenecarboxaldehyde (10.1 g, 50 mmol) was first dissolved in 250 mL of ethanol at 0 °C. Subsequently, NaBH4 (1.88 g, 50 mmol) was added to the stirring solution in batches (0.3 g each). The reaction mixture was stirred continuously for 18 hours at room temperature. Upon completion of the reaction, ethanol was evaporated under reduced pressure conditions (102 mbar) and the light yellow solid obtained was dissolved in 200 mL of saturated aqueous NH4Cl solution. The crude product was extracted by ether (three times, 80 mL each). The combined organic phases were washed with brine (three times, 20 mL each) and dried with MgSO4 for 2 hours. After drying, the MgSO4 was removed by filtration and the excess solvent was evaporated under reduced pressure (102 mbar). The product was purified by fast chromatography on a silica gel column with hexane/ethyl acetate (8:2, v/v) as eluent. Eventually, evaporation of the solvent gave a colorless solid product (8.52 g, 84% yield).

References

[1] Tetrahedron Asymmetry, 2011, vol. 22, # 13, p. 1395 - 1399
[2] Journal of Chemical Research - Part S, 2003, # 6, p. 335 - 339
[3] Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2003, vol. 58, # 12, p. 1220 - 1226
[4] Bulletin of the Chemical Society of Japan, 2005, vol. 78, # 2, p. 307 - 315
[5] Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2005, vol. 60, # 4, p. 453 - 457

5-Bromo-2-hydroxybenzyl alcohol Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Bromo-2-hydroxybenzyl alcohol Suppliers

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View Lastest Price from 5-Bromo-2-hydroxybenzyl alcohol manufacturers

Career Henan Chemical Co

Product: 5-Bromo-2-hydroxybenzyl alcohol 2316-64-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 200kg
Release date: 2018-12-24

2316-64-5, 5-Bromo-2-hydroxybenzyl alcoholRelated Search:

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4-BROMO-2-HYDROXYMETHYLPHENOL

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5-BROMO-2-HYDROXYBENZYL ALCOHOL, 98+%

5-BROMO-2-HYDROXYBENZYL ALCOHOL 98%

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4-Bromo-2-hydroxymethylphenol 2-Hydroxymethyl-4-bromophenol

5-Bromo-2-hydroxybenzenemethanol

5-Bromo-2-hydroxybenzyl Alcohol &gt

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2316-64-5

BrC6H3OHCH2OH

C7H7BrO2

C7 to C8

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