LL-Z-1640-2

Product Name: LL-Z-1640-2
CAS No.: 66018-38-0
Chemical Name: LL-Z-1640-2
Synonyms: LL-Z-1640-2;C292, L 783278;JNK/p38 inhibitor;(5Z)-7-Oxozeaenol;(5Z)-7-Oxozeaenol (5Z-7-oxozeaenol);5,6,15-trihydroxy-17-methoxy-11-methyl-12-oxabicyclo[12.4.0]octadeca-1(14),2,8,15,17-pentaene-7,13-dione;(3S,5Z,8S,9S,11E)-3,4,9,10-tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione
CBNumber: CB6270733
Molecular Formula: C19H22O7
Formula Weight: 362.37
MOL File: 66018-38-0.mol

More

Less

LL-Z-1640-2 Property

storage temp.: Desiccate at -20°C
solubility: Soluble in DMSO
form: White solid

More

Less

Safety

Hazard Codes: Xi

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P321Specific treatment (see … on this label).

P405Store locked up.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 499610
Product name: (5Z)-7-Oxozeaenol, Curvularia sp. - CAS 66018-38-0 - Calbiochem<br />(5Z)-7-Oxozeaenol, CAS 66018-38-0, is a cell-permeable, highly potent, selective, irreversible, and ATP-competitive inhibitor of MAPKKK TAK1 activity (IC = 8 nM).
Packaging: 1mg
Price: $159
Updated: 2024/03/01

Alfa Aesar

Product number: J66651
Product name: 5Z-7-Oxozeaenol
Packaging: 1mg
Price: $125.65
Updated: 2024/03/01

Alfa Aesar

Product number: J66651
Product name: 5Z-7-Oxozeaenol
Packaging: 5mg
Price: $509.65
Updated: 2024/03/01

Tocris

Product number: 3604
Product name: (5Z)-7-Oxozeaenol
Purity: ≥98%(HPLC)
Packaging: 1
Price: $176
Updated: 2021/12/16

TRC

Product number: A697425
Product name: AntibioticLLZ1640-2
Packaging: 1mg
Price: $105
Updated: 2021/12/16

More

Less

LL-Z-1640-2 Chemical Properties,Usage,Production

Uses

LL Z1640-2 is a cis-enone resorcylic acid lactone first reported in 1978 and later rediscovered as an irreversible and highly selective TAK 1 inhibitor. TAK1 is a MAPKKK involved in the p38 signalling cascade for pro-inflammation signals such as cytokines. LL Z1640-2 effectively prevents inflammation in animal models.

Biological Activity

Resorcyclic lactone of fungal origin that acts as a potent and selective transforming growth factor- β -activated kinase 1 (TAK1) mitogen-activated protein kinase kinase kinase (MAPKKK) inhibitor (IC 50 = 8 nM). Displays > 33-fold and > 62-fold selectivity over MEKK1 and MEKK4 respectively. Inhibits IL-1-induced activation of NF- κ B (IC 50 = 83 nM) and JNK/p38. Inhibits production of inflammatory mediators, and sensitizes cells to TRAIL- and TNF- α -induced apoptosis in vitro .

LL-Z-1640-2 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

LL-Z-1640-2 Suppliers

China 37 Germany 2 India 1 United Kingdom 3 United States 3 Global 46

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8447
Advantage: 60

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

Lynnchem

Tel: 86-(0)29-85992781 17792393971
Email: info@lynnchem.com
Country: China
ProdList: 4587
Advantage: 58

Novachemistry

Tel: 44-20819178-90 02081917890
Fax: (0)2080432064
Email: info@novachemistry.com
Country: United Kingdom
ProdList: 4381
Advantage: 58

BOC Sciences

Tel: 16314854226; +16314854226
Email: inquiry@bocsci.com
Country: United States
ProdList: 19741
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

Changzhou Furuisi Biotechnology Co., Ltd

Tel: 0519-85524369
Email: 3477467573@qq.com
Country: China
ProdList: 8617
Advantage: 58

Shanghai Universal Biotech Co.,Ltd

Tel: 13774214275
Email: zhouzz@univ-bio.com
Country: China
ProdList: 24990
Advantage: 58

66018-38-0, LL-Z-1640-2Related Search:

methyl 4-methoxy-2-methylbenzoate 4-Methoxysalicylic acid 2-VINYL-BENZOIC ACID ETHYL ESTER Ethyl 2,4-dihydroxy-6-methylbenzoate LL-Z-1640-2

(3S,5Z,8S,9S,11E)-3,4,9,10-tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione

(5Z)-7-Oxozeaenol

JNK/p38 inhibitor

C292, L 783278

LL-Z-1640-2

(5Z)-7-Oxozeaenol (5Z-7-oxozeaenol)

5,6,15-trihydroxy-17-methoxy-11-methyl-12-oxabicyclo[12.4.0]octadeca-1(14),2,8,15,17-pentaene-7,13-dione

66018-38-0

antibiotic