LL-Z-1640-2
- Product Name
- LL-Z-1640-2
- CAS No.
- 66018-38-0
- Chemical Name
- LL-Z-1640-2
- Synonyms
- LL-Z-1640-2;C292, L 783278;JNK/p38 inhibitor;(5Z)-7-Oxozeaenol;(5Z)-7-Oxozeaenol (5Z-7-oxozeaenol);5,6,15-trihydroxy-17-methoxy-11-methyl-12-oxabicyclo[12.4.0]octadeca-1(14),2,8,15,17-pentaene-7,13-dione;(3S,5Z,8S,9S,11E)-3,4,9,10-tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione
- CBNumber
- CB6270733
- Molecular Formula
- C19H22O7
- Formula Weight
- 362.37
- MOL File
- 66018-38-0.mol
LL-Z-1640-2 Property
- storage temp.
- Desiccate at -20°C
- solubility
- Soluble in DMSO
- form
- White solid
Safety
- Hazard Codes
- Xi
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H301Toxic if swalloed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P321Specific treatment (see … on this label).
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 499610
- Product name
- (5Z)-7-Oxozeaenol, Curvularia sp. - CAS 66018-38-0 - Calbiochem<br />(5Z)-7-Oxozeaenol, CAS 66018-38-0, is a cell-permeable, highly potent, selective, irreversible, and ATP-competitive inhibitor of MAPKKK TAK1 activity (IC = 8 nM).
- Packaging
- 1mg
- Price
- $159
- Updated
- 2024/03/01
- Product number
- J66651
- Product name
- 5Z-7-Oxozeaenol
- Packaging
- 1mg
- Price
- $125.65
- Updated
- 2024/03/01
- Product number
- J66651
- Product name
- 5Z-7-Oxozeaenol
- Packaging
- 5mg
- Price
- $509.65
- Updated
- 2024/03/01
- Product number
- 3604
- Product name
- (5Z)-7-Oxozeaenol
- Purity
- ≥98%(HPLC)
- Packaging
- 1
- Price
- $176
- Updated
- 2021/12/16
- Product number
- A697425
- Product name
- AntibioticLLZ1640-2
- Packaging
- 1mg
- Price
- $105
- Updated
- 2021/12/16
LL-Z-1640-2 Chemical Properties,Usage,Production
Uses
LL Z1640-2 is a cis-enone resorcylic acid lactone first reported in 1978 and later rediscovered as an irreversible and highly selective TAK 1 inhibitor. TAK1 is a MAPKKK involved in the p38 signalling cascade for pro-inflammation signals such as cytokines. LL Z1640-2 effectively prevents inflammation in animal models.
Biological Activity
Resorcyclic lactone of fungal origin that acts as a potent and selective transforming growth factor- β -activated kinase 1 (TAK1) mitogen-activated protein kinase kinase kinase (MAPKKK) inhibitor (IC 50 = 8 nM). Displays > 33-fold and > 62-fold selectivity over MEKK1 and MEKK4 respectively. Inhibits IL-1-induced activation of NF- κ B (IC 50 = 83 nM) and JNK/p38. Inhibits production of inflammatory mediators, and sensitizes cells to TRAIL- and TNF- α -induced apoptosis in vitro .