ChemicalBook > CAS DataBase List > LL-Z-1640-2

LL-Z-1640-2

Product Name
LL-Z-1640-2
CAS No.
66018-38-0
Chemical Name
LL-Z-1640-2
Synonyms
LL-Z-1640-2;C292, L 783278;JNK/p38 inhibitor;(5Z)-7-Oxozeaenol;(5Z)-7-Oxozeaenol (5Z-7-oxozeaenol);(5Z)-7-Oxozeaenol, Curvularia sp.;5,6,15-trihydroxy-17-methoxy-11-methyl-12-oxabicyclo[12.4.0]octadeca-1(14),2,8,15,17-pentaene-7,13-dione;(3S,5Z,8S,9S,11E)-3,4,9,10-tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione
CBNumber
CB6270733
Molecular Formula
C19H22O7
Formula Weight
362.37
MOL File
66018-38-0.mol
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LL-Z-1640-2 Property

storage temp. 
Desiccate at -20°C
solubility 
Soluble in DMSO
form 
White solid
color 
white
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Safety

Hazard Codes 
Xi
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P321Specific treatment (see … on this label).

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
499610
Product name
(5Z)-7-Oxozeaenol, Curvularia sp. - CAS 66018-38-0 - Calbiochem<br />(5Z)-7-Oxozeaenol, CAS 66018-38-0, is a cell-permeable, highly potent, selective, irreversible, and ATP-competitive inhibitor of MAPKKK TAK1 activity (IC = 8 nM).
Packaging
1mg
Price
$163
Updated
2025/07/31
Tocris
Product number
3604
Product name
(5Z)-7-Oxozeaenol
Purity
≥98%(HPLC)
Packaging
1
Price
$176
Updated
2021/12/16
TRC
Product number
A697425
Product name
AntibioticLLZ1640-2
Packaging
1mg
Price
$105
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0014467
Product name
LL-Z-1640-2
Purity
95.00%
Packaging
5MG
Price
$1016.64
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0014467
Product name
LL-Z-1640-2
Purity
95.00%
Packaging
10MG
Price
$1174.17
Updated
2021/12/16
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LL-Z-1640-2 Chemical Properties,Usage,Production

Uses

LL Z1640-2 is a cis-enone resorcylic acid lactone first reported in 1978 and later rediscovered as an irreversible and highly selective TAK 1 inhibitor. TAK1 is a MAPKKK involved in the p38 signalling cascade for pro-inflammation signals such as cytokines. LL Z1640-2 effectively prevents inflammation in animal models.

Biological Activity

Resorcyclic lactone of fungal origin that acts as a potent and selective transforming growth factor- β -activated kinase 1 (TAK1) mitogen-activated protein kinase kinase kinase (MAPKKK) inhibitor (IC 50 = 8 nM). Displays > 33-fold and > 62-fold selectivity over MEKK1 and MEKK4 respectively. Inhibits IL-1-induced activation of NF- κ B (IC 50 = 83 nM) and JNK/p38. Inhibits production of inflammatory mediators, and sensitizes cells to TRAIL- and TNF- α -induced apoptosis in vitro .

LL-Z-1640-2 Preparation Products And Raw materials

Raw materials

Preparation Products

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LL-Z-1640-2 Suppliers

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66018-38-0, LL-Z-1640-2Related Search:

methyl 4-methoxy-2-methylbenzoate 4-Methoxysalicylic acid 2-VINYL-BENZOIC ACID ETHYL ESTER Ethyl 2,4-dihydroxy-6-methylbenzoate LL-Z-1640-2

  • (3S,5Z,8S,9S,11E)-3,4,9,10-tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione
  • (5Z)-7-Oxozeaenol
  • JNK/p38 inhibitor
  • C292, L 783278
  • LL-Z-1640-2
  • (5Z)-7-Oxozeaenol (5Z-7-oxozeaenol)
  • 5,6,15-trihydroxy-17-methoxy-11-methyl-12-oxabicyclo[12.4.0]octadeca-1(14),2,8,15,17-pentaene-7,13-dione
  • (5<i>Z</i>)-7-Oxozeaenol, <i>Curvularia</i> sp.
  • 66018-38-0
  • antibiotic