LL-Z-1640-2

Product Name: LL-Z-1640-2
CAS No.: 66018-38-0
Chemical Name: LL-Z-1640-2
Synonyms: LL-Z-1640-2;C292, L 783278;JNK/p38 inhibitor;(5Z)-7-Oxozeaenol;(5Z)-7-Oxozeaenol (5Z-7-oxozeaenol);5,6,15-trihydroxy-17-methoxy-11-methyl-12-oxabicyclo[12.4.0]octadeca-1(14),2,8,15,17-pentaene-7,13-dione;(3S,5Z,8S,9S,11E)-3,4,9,10-tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione
CBNumber: CB6270733
Molecular Formula: C19H22O7
Formula Weight: 362.37
MOL File: 66018-38-0.mol

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LL-Z-1640-2 Property

storage temp.: Desiccate at -20°C
solubility: Soluble in DMSO
form: White solid

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Safety

Hazard Codes: Xi

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P321Specific treatment (see … on this label).

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 499610
Product name: (5Z)-7-Oxozeaenol, Curvularia sp. - CAS 66018-38-0 - Calbiochem<br />(5Z)-7-Oxozeaenol, CAS 66018-38-0, is a cell-permeable, highly potent, selective, irreversible, and ATP-competitive inhibitor of MAPKKK TAK1 activity (IC = 8 nM).
Packaging: 1mg
Price: $159
Updated: 2024/03/01

Alfa Aesar

Product number: J66651
Product name: 5Z-7-Oxozeaenol
Packaging: 1mg
Price: $125.65
Updated: 2024/03/01

Alfa Aesar

Product number: J66651
Product name: 5Z-7-Oxozeaenol
Packaging: 5mg
Price: $509.65
Updated: 2024/03/01

Tocris

Product number: 3604
Product name: (5Z)-7-Oxozeaenol
Purity: ≥98%(HPLC)
Packaging: 1
Price: $176
Updated: 2021/12/16

TRC

Product number: A697425
Product name: AntibioticLLZ1640-2
Packaging: 1mg
Price: $105
Updated: 2021/12/16

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LL-Z-1640-2 Chemical Properties,Usage,Production

Uses

LL Z1640-2 is a cis-enone resorcylic acid lactone first reported in 1978 and later rediscovered as an irreversible and highly selective TAK 1 inhibitor. TAK1 is a MAPKKK involved in the p38 signalling cascade for pro-inflammation signals such as cytokines. LL Z1640-2 effectively prevents inflammation in animal models.

Biological Activity

Resorcyclic lactone of fungal origin that acts as a potent and selective transforming growth factor- β -activated kinase 1 (TAK1) mitogen-activated protein kinase kinase kinase (MAPKKK) inhibitor (IC 50 = 8 nM). Displays > 33-fold and > 62-fold selectivity over MEKK1 and MEKK4 respectively. Inhibits IL-1-induced activation of NF- κ B (IC 50 = 83 nM) and JNK/p38. Inhibits production of inflammatory mediators, and sensitizes cells to TRAIL- and TNF- α -induced apoptosis in vitro .

LL-Z-1640-2 Preparation Products And Raw materials

Raw materials

Preparation Products

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LL-Z-1640-2 Suppliers

China 37 Germany 2 India 1 United Kingdom 3 United States 3 Global 46

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66018-38-0, LL-Z-1640-2Related Search:

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(3S,5Z,8S,9S,11E)-3,4,9,10-tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione

(5Z)-7-Oxozeaenol

JNK/p38 inhibitor

C292, L 783278

LL-Z-1640-2

(5Z)-7-Oxozeaenol (5Z-7-oxozeaenol)

5,6,15-trihydroxy-17-methoxy-11-methyl-12-oxabicyclo[12.4.0]octadeca-1(14),2,8,15,17-pentaene-7,13-dione

66018-38-0

antibiotic