ChemicalBook > CAS DataBase List > BOC-D-ALPHA-T-BUTYLGLYCINE

BOC-D-ALPHA-T-BUTYLGLYCINE

Product Name: BOC-D-ALPHA-T-BUTYLGLYCINE
CAS No.: 124655-17-0
Chemical Name: BOC-D-ALPHA-T-BUTYLGLYCINE
Synonyms: Boc-D-Tle;Boc-D-t-Leu;BOC-D-TLE-OH;Boc-D-Tle-0H;BOC-TBU-D-GLY-OH;BOC-D-(TBU)GLY-OH;BOC-D-TERT-LEUCINE;BOC-D- Tert-Leu-OH;N-BOC-D-TERT-LEUCINE;BOC-D-T-BUTYLGLYCINE
CBNumber: CB6271402
Molecular Formula: C11H21NO4
Formula Weight: 231.29
MOL File: 124655-17-0.mol

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BOC-D-ALPHA-T-BUTYLGLYCINE Property

Melting point:: 118-121°C
Boiling point:: 350.0±25.0 °C(Predicted)
Density: 1.063±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: slightly sol. in Methanol
pka: 4.03±0.10(Predicted)
form: Solid
color: White to Almost white
optical activity: Consistent with structure
InChI: InChI=1S/C11H21NO4/c1-10(2,3)7(8(13)14)12-9(15)16-11(4,5)6/h7H,1-6H3,(H,12,15)(H,13,14)/t7-/m0/s1
InChIKey: LRFZIPCTFBPFLX-ZETCQYMHSA-N
SMILES: C(O)(=O)[C@@H](C(C)(C)C)NC(OC(C)(C)C)=O
CAS DataBase Reference: 124655-17-0(CAS DataBase Reference)

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Safety

HazardClass: IRRITANT
HS Code: 2924190090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: B3995
Product name: N-(tert-Butoxycarbonyl)-D-tert-leucine
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $46
Updated: 2025/07/31

TCI Chemical

Product number: B3995
Product name: N-(tert-Butoxycarbonyl)-D-tert-leucine
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $183
Updated: 2025/07/31

TRC

Product number: B667830
Product name: N-Boc-D-tert-leucine
Packaging: 2.5g
Price: $385
Updated: 2021/12/16

Oakwood

Product number: 037132
Product name: N-Boc-D-tert-leucine
Purity: 95%
Packaging: 250mg
Price: $12
Updated: 2021/12/16

Chem-Impex

Product number: 01354
Product name: Boc-D-α-tert-butylglycine,98%(HPLC)
Purity: 98%(HPLC)
Packaging: 1G
Price: $22.4
Updated: 2021/12/16

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BOC-D-ALPHA-T-BUTYLGLYCINE Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

N-Boc-D-tert-leucine is a protected form of D-tert-leucine, and is used in the synthesis of primary amino acid derivatives (e.g. Desacetyl Desmethyl Lacosamide [D288325]) that possess anticonvulsant and neuropathic pain protection properties.

Synthesis

26782-71-8

24424-99-5

124655-17-0

General procedure for the synthesis of tert-butoxycarbonyl-D-tert-leucine from D-tert-leucine and di-tert-butyl dicarbonate: 3-methyl-D-valine (900 mg, 6.86 mmol) was dissolved in a mixture of 7 mL of a 1 M aqueous sodium hydroxide solution and 7 mL of methanol at 0°C, followed by the addition of di-tert-butyl dicarbonate (Boc-anhydride, 1.797 g, 8.23 mmol). The reaction mixture was gradually warmed to room temperature and stirred continuously overnight. Upon completion of the reaction, most of the methanol was removed by evaporation, and the reaction solution was acidified to pH 2 with 1 M aqueous HCl, followed by three extractions with ethyl acetate (3 × 20 mL). The organic phases were combined and washed twice with brine (2 × 5 mL). Finally, the solvent was removed by evaporation to afford tert-butoxycarbonyl-D-tert-leucine as a white solid in 83% yield (1.36 g). The product was characterized by NMR (400 MHz, DMSO-d6): δ 12.44 (1H, s), 6.82 (1H, d), 3.76 (1H, d), 1.38 (9H, s); UPLC analysis showed a retention time of 0.64 min and a molecular ion peak of 232 [M + H]+.

References

[1] Patent: WO2011/69951, 2011, A1. Location in patent: Page/Page column 77
[2] Journal of Medicinal Chemistry, 2008, vol. 51, # 15, p. 4620 - 4631
[3] Journal of Medicinal Chemistry, 2011, vol. 54, # 13, p. 4815 - 4830
[4] Patent: WO2012/76877, 2012, A1. Location in patent: Page/Page column 97
[5] Patent: US2013/267510, 2013, A1. Location in patent: Paragraph 0708-0710

BOC-D-ALPHA-T-BUTYLGLYCINE Preparation Products And Raw materials

Raw materials

Preparation Products

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BOC-D-ALPHA-T-BUTYLGLYCINE Suppliers

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View Lastest Price from BOC-D-ALPHA-T-BUTYLGLYCINE manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: BOC-D-ALPHA-T-BUTYLGLYCINE 124655-17-0
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-05

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Boc-D-Tle-OH 124655-17-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T
Release date: 2023-11-21

Sichuan Jiaying Lai Technology Co.,LTD

Product: Boc-D-Tle-OH 124655-17-0
Price: US $1.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 100KG
Release date: 2019-07-21

124655-17-0, BOC-D-ALPHA-T-BUTYLGLYCINERelated Search:

N-Boc-D-Valino BOC-D-THR-OH N-Boc-L-valine Boc-D-Thr-Obzl Boc-beta-alanine N-(tert-Butoxycarbonyl)-L-alanine BOC-BETA-TBU-D-ALA-OH 4-(Aminocarbonyl)-N-[(1,1-dimethylethoxy)carbonyl]-2,6-dimethyl-L-phenylalanine (BOC-AMINOOXY)ACETIC ACID TERT-BUTOXY ACETIC ACID Boc-L-aspartic acid 4-tert-butyl ester Boc-D-aspartic acid 4-benzyl ester TERT-BUTYL N-ALLYLCARBAMATE BOC-ALA-GLY-OH BOC-HYP-OL N-Boc-L-Phenylalaninol N-Boc-exo-3-aminotropane BOC-D-Methionine

(R)-2-((tert-Butoxycarbonyl)aMino)-3,3-diMethylbutanoic acid

Boc-D-t-Leu

N-alpha-t-Butyloxycarbonyl-D-t-leucine, N-alpha-t-Butyloxycarbonyl-D-t-butylglycine

N-BOC-D-TERT-LEUCINE

(R)-2-(tert-butoxycarbonyl)-3,3-dimethylbutanoic a

BOC-TBU-D-GLY-OH

BOC-D-(TBU)GLY-OH

BOC-D-T-BUTYLGLYCINE

BOC-D-TERT-LEUCINE

BOC-D-TLE-OH

BOC-D-ALPHA-T-BUTYLGLYCINE

BOC-D-ALPHA-T-BUTYL-GLY-OH

N-ALPHA-T-BOC-D-ALPHA-T-BUTYLGLYCINE

N-ALPHA-T-BOC-D-T-LEUCINE

N-ALPHA-T-BUTOXYCARBONYL-D-L-BUTYLGLYCINE

N-ALPHA-T-BUTOXYCARBONYL-D-T-BUTYLGLYCINE

N-ALPHA-T-BUTOXYCARBONYL-D-T-LEUCINE

(R)-N-ALPHA-T-BUTOXYCARBONYL-2-AMINO-3,3-DIMETHYL-BUTYRIC ACID

(R)-N-(TERT-BUTOXYCARBONYL)-TERT-LEUCINE

N-(tert-Butoxycarbonyl)-D-tert-leucine

N-(tert-Butoxycarbonyl)-D-tert-leucine

D-Valine, N-[(1,1-dimethylethoxy)carbonyl]-3-methyl-

(R)-N-Boc-2-amino-3,3-dimethylbutyric acid

Boc-D-α-tert-butylglycine≥ 98% (HPLC)

Boc-D-α-tert-butyl-Gly-OH

N-Boc-D-tert-leucine,99%e.e.

2-{[(tert-Butoxycarbonyl)amino]methyl}-3,3-dimethylbutanoic acid

(Tert-Butoxy)Carbonyl D-Tle-OH

(2R)-2-{[(tert-butoxy)carbonyl]amino}-3,3-dimethylbutanoic acid

Boc-D-Tle

(2R)-3,3-dimethyl-2-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]butanoic acid

N-(tert-Butoxycarbonyl)-D-tert-leucine &gt

(2R)-3,3-dimethyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoic acid

N-Boc-D-tert-leucine,95%

(2R)-3,3-dimethyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoicaci

(R)-2-(Boc-amino)-3,3-dimethylbutyric Acid

(R)-2-(tert-Butoxycarbonylamino)-3,3-dimethylbutyric Acid

BOC-D-ALPHA-T-BUTYLGLYCINE USP/EP/BP

Boc-D-α-tert-butylglycine

124655-17-0 BOC-D-ALPHA-T-BUTYLGLYCINE

(2R)-3,3-dimethyl-2-[(2-methylpropan-2-yl)oxycarbonylamin

BOC-D-ALPHA-T-BUTYLGLYCINE Powder USP Standard

BOC-D- Tert-Leu-OH

2,4-Dichlorobenzyl Alcohol Impurity 9

Boc-D-Tle-0H

124655-17-0

C11H21NO4

Amino Acids

CHIRAL COMPOUNDS

Amino Acids & Deriv.

CHIRAL CHEMICALS

Peptide