BV6

ChemicalBook > CAS DataBase List > BV6

Product Name: BV6
CAS No.: 1001600-56-1
Chemical Name: BV6
Synonyms: BV6;CS-1501;CS-2877;BV-6;BV6;BV-6 TFA;BV-6 free;CHEBI:47924;BV6 TFA salt;BV6 USP/EP/BP;CHEBI:47924; BV-6 BV 6
CBNumber: CB62715614
Molecular Formula: C70H96N10O8
Formula Weight: 1205.57
MOL File: 1001600-56-1.mol

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BV6 Property

Boiling point:: 1376.7±65.0 °C(Predicted)
Density: 1.177±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility: ≥60.28 mg/mL in DMSO; insoluble in H2O; ≥12.6 mg/mL in EtOH with ultrasonic
form: solid
pka: 12.89±0.20(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 28830
Product name: BV6
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 28830
Product name: BV6
Packaging: 10mg
Price: $321
Updated: 2024/03/01

Cayman Chemical

Product number: 28830
Product name: BV6
Packaging: 5mg
Price: $172
Updated: 2024/03/01

TRC

Product number: B810530
Product name: BV-6
Packaging: 5mg
Price: $130
Updated: 2021/12/16

ApexBio Technology

Product number: B4653
Product name: BV6
Packaging: 10mM(in 1mL DMSO)
Price: $290
Updated: 2021/12/16

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BV6 Chemical Properties,Usage,Production

Description

BV6 is a bivalent Smac mimetic and an antagonist of the inhibitor of apoptosis (IAP) proteins that binds to IAP1 and XIAP (K_ds = 0.46 and 1.3 nM, respectively). It induces autoubiquitination and proteasomal degradation of IAP1 and XIAP in MDA-MB-231 cells when used at a concentration of 5 μM. BV6 (4 μM) induces NF-κB activation and TNF-dependent apoptosis in A2058 and MDA-MB-231 cells. It enhances radiosensitization and increases apoptosis in HCC193 and H460 non-small cell lung cancer (NSCLC) cell lines. BV6 (1 μM) induces cell death in a panel of 40 primary, patient-derived B cell precursor acute lymphoblastic leukemia (BCP-ALL) samples in a TNF-dependent manner. In vivo, BV6 (10 mg/kg) increases survival and the time to relapse in a high-risk BCP-ALL patient-derived xenograft (PDX) mouse model.

Uses

BV-6 is a SMAC mimetic and inhibitor of apoptosis (IAP) inhibitor. Apoptosis agent.

Definition

ChEBI: N,N'-(hexane-1,6-diyl)bis(1-{(2S)-2-cyclohexyl-2-[(N-methyl-L-alanyl)amino]acetyl}-L-prolyl-beta-phenyl-L-phenylalaninamide) is a polyamide consisting of hexane-1,6-diamine having a 1-{(2S)-2-cyclohexyl-2-[(N-methyl-L-alanyl)amino]acetyl}-L-prolyl-beta-phenyl-L-phenylalanyl moiety attached to both nitrogens. It is functionally related to a methyl 1-{(2S)-2-cyclohexyl-2-[(N-methyl-L-alanyl)amino]acetyl}-L-prolyl-beta-phenyl-L-phenylalaninate.

BV6 Preparation Products And Raw materials

Raw materials

Preparation Products

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1001600-56-1, BV6Related Search:

LCL-161 MG-132 Birinapant Rapamycin Doxorubicin hydrochloride

4,4'-(1,6-Hexanediyl)bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-L-prolyl-beta-phenyl-L-phenylalaninamide

BV6

N,N'-(hexane-1,6-diyl)bis(1-{(2S)-2-cyclohexyl-2-[(N-methyl-L-alanyl)amino]acetyl}-L-prolyl-beta-phenyl-L-phenylalaninamide):trifluoroacetic acid(1:x)

CHEBI:47924

CHEBI:47924; BV-6 BV 6

CS-2877

CS-1501

BV-6;BV6

4,4'-(1,6-Hexanediyl)bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-L-prolyl-β-phenyl-L-Phenylalanin

BV-6 TFA

L-Phenylalaninamide, 4,4'-(1,6-hexanediyl)bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-L-prolyl-β-phenyl-

BV6 USP/EP/BP

BV-6 free

BV6 TFA salt

inhibit,Inhibitor,BV6,IAP,BV-6,BV 6

(2S,2'S)-N,N'-((2S,2'S)-(Hexane-1,6-diylbis(azanediyl))bis(1-oxo-3,3-diphenylpropane-1,2-diyl))bis(1-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)pyrrolidine-2-carboxamide)

(2S)-2-{[(2S)-1-[(2S)-2-cyclohexyl-2-[(2S)-2-(methylamino)propanamido]acetyl]pyrrolidin-2-yl]formamido}-N-{6-[(2S)-2-{[(2S)-1-[(2S)-2-cyclohexyl-2-[(2S)-2-(methylamino)propanamido]acetyl]pyrrolidin-2-yl]formamido}-3,3-diphenylpropanamido]hexyl}-3,3-diphenylpropanamide

1001600-56-1

C70H96N10O8

C70H96N10O8xCF3COOH

Inhibitors