ChemicalBook > CAS DataBase List > BV6

BV6

Product Name
BV6
CAS No.
1001600-56-1
Chemical Name
BV6
Synonyms
BV6;CS-1501;CS-2877;BV-6;BV6;BV-6 TFA;BV-6 free;CHEBI:47924;BV6 TFA salt;BV6 USP/EP/BP;CHEBI:47924; BV-6 BV 6
CBNumber
CB62715614
Molecular Formula
C70H96N10O8
Formula Weight
1205.57
MOL File
1001600-56-1.mol
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BV6 Property

Boiling point:
1376.7±65.0 °C(Predicted)
Density 
1.177±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 
≥60.28 mg/mL in DMSO; insoluble in H2O; ≥12.6 mg/mL in EtOH with ultrasonic
form 
solid
pka
12.89±0.20(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
28830
Product name
BV6
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
28830
Product name
BV6
Packaging
10mg
Price
$321
Updated
2024/03/01
Cayman Chemical
Product number
28830
Product name
BV6
Packaging
5mg
Price
$172
Updated
2024/03/01
TRC
Product number
B810530
Product name
BV-6
Packaging
5mg
Price
$130
Updated
2021/12/16
ApexBio Technology
Product number
B4653
Product name
BV6
Packaging
10mM(in 1mL DMSO)
Price
$290
Updated
2021/12/16
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BV6 Chemical Properties,Usage,Production

Description

BV6 is a bivalent Smac mimetic and an antagonist of the inhibitor of apoptosis (IAP) proteins that binds to IAP1 and XIAP (Kds = 0.46 and 1.3 nM, respectively). It induces autoubiquitination and proteasomal degradation of IAP1 and XIAP in MDA-MB-231 cells when used at a concentration of 5 μM. BV6 (4 μM) induces NF-κB activation and TNF-dependent apoptosis in A2058 and MDA-MB-231 cells. It enhances radiosensitization and increases apoptosis in HCC193 and H460 non-small cell lung cancer (NSCLC) cell lines. BV6 (1 μM) induces cell death in a panel of 40 primary, patient-derived B cell precursor acute lymphoblastic leukemia (BCP-ALL) samples in a TNF-dependent manner. In vivo, BV6 (10 mg/kg) increases survival and the time to relapse in a high-risk BCP-ALL patient-derived xenograft (PDX) mouse model.

Uses

BV-6 is a SMAC mimetic and inhibitor of apoptosis (IAP) inhibitor. Apoptosis agent.

Definition

ChEBI: N,N'-(hexane-1,6-diyl)bis(1-{(2S)-2-cyclohexyl-2-[(N-methyl-L-alanyl)amino]acetyl}-L-prolyl-beta-phenyl-L-phenylalaninamide) is a polyamide consisting of hexane-1,6-diamine having a 1-{(2S)-2-cyclohexyl-2-[(N-methyl-L-alanyl)amino]acetyl}-L-prolyl-beta-phenyl-L-phenylalanyl moiety attached to both nitrogens. It is functionally related to a methyl 1-{(2S)-2-cyclohexyl-2-[(N-methyl-L-alanyl)amino]acetyl}-L-prolyl-beta-phenyl-L-phenylalaninate.

BV6 Preparation Products And Raw materials

Raw materials

Preparation Products

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BV6 Suppliers

China 72 France 1 India 1 United States 14 Global 88
Hangzhou Peptidego Biotech Co.,Ltd.
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1001600-56-1, BV6Related Search:

LCL-161 MG-132 Birinapant Rapamycin Doxorubicin hydrochloride

  • 4,4'-(1,6-Hexanediyl)bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-L-prolyl-beta-phenyl-L-phenylalaninamide
  • BV6
  • N,N'-(hexane-1,6-diyl)bis(1-{(2S)-2-cyclohexyl-2-[(N-methyl-L-alanyl)amino]acetyl}-L-prolyl-beta-phenyl-L-phenylalaninamide):trifluoroacetic acid(1:x)
  • CHEBI:47924
  • CHEBI:47924; BV-6 BV 6
  • CS-2877
  • CS-1501
  • BV-6;BV6
  • 4,4'-(1,6-Hexanediyl)bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-L-prolyl-β-phenyl-L-Phenylalanin
  • BV-6 TFA
  • L-Phenylalaninamide, 4,4'-(1,6-hexanediyl)bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-L-prolyl-β-phenyl-
  • BV6 USP/EP/BP
  • BV-6 free
  • BV6 TFA salt
  • inhibit,Inhibitor,BV6,IAP,BV-6,BV 6
  • (2S,2'S)-N,N'-((2S,2'S)-(Hexane-1,6-diylbis(azanediyl))bis(1-oxo-3,3-diphenylpropane-1,2-diyl))bis(1-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)pyrrolidine-2-carboxamide)
  • (2S,2'S)-N,N'-((2S,2'S)-(Hexane-1,6-diylbis(azanediyl))bis(1-oxo-3,3-diphenylpropane-1,2-diyl))bis(1-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)pyrrolidine-2-carboxamide)
  • 1001600-56-1
  • C70H96N10O8
  • C70H96N10O8xCF3COOH
  • Inhibitors