BV6
- Product Name
- BV6
- CAS No.
- 1001600-56-1
- Chemical Name
- BV6
- Synonyms
- BV6;CS-1501;CS-2877;BV-6;BV6;BV-6 TFA;BV-6 free;CHEBI:47924;BV6 TFA salt;BV6 USP/EP/BP;CHEBI:47924; BV-6 BV 6
- CBNumber
- CB62715614
- Molecular Formula
- C70H96N10O8
- Formula Weight
- 1205.57
- MOL File
- 1001600-56-1.mol
BV6 Property
- Boiling point:
- 1376.7±65.0 °C(Predicted)
- Density
- 1.177±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- solubility
- ≥60.28 mg/mL in DMSO; insoluble in H2O; ≥12.6 mg/mL in EtOH with ultrasonic
- form
- solid
- pka
- 12.89±0.20(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 28830
- Product name
- BV6
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 28830
- Product name
- BV6
- Packaging
- 10mg
- Price
- $321
- Updated
- 2024/03/01
- Product number
- 28830
- Product name
- BV6
- Packaging
- 5mg
- Price
- $172
- Updated
- 2024/03/01
- Product number
- B810530
- Product name
- BV-6
- Packaging
- 5mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- B4653
- Product name
- BV6
- Packaging
- 10mM(in 1mL DMSO)
- Price
- $290
- Updated
- 2021/12/16
BV6 Chemical Properties,Usage,Production
Description
BV6 is a bivalent Smac mimetic and an antagonist of the inhibitor of apoptosis (IAP) proteins that binds to IAP1 and XIAP (Kds = 0.46 and 1.3 nM, respectively). It induces autoubiquitination and proteasomal degradation of IAP1 and XIAP in MDA-MB-231 cells when used at a concentration of 5 μM. BV6 (4 μM) induces NF-κB activation and TNF-dependent apoptosis in A2058 and MDA-MB-231 cells. It enhances radiosensitization and increases apoptosis in HCC193 and H460 non-small cell lung cancer (NSCLC) cell lines. BV6 (1 μM) induces cell death in a panel of 40 primary, patient-derived B cell precursor acute lymphoblastic leukemia (BCP-ALL) samples in a TNF-dependent manner. In vivo, BV6 (10 mg/kg) increases survival and the time to relapse in a high-risk BCP-ALL patient-derived xenograft (PDX) mouse model.
Uses
BV-6 is a SMAC mimetic and inhibitor of apoptosis (IAP) inhibitor. Apoptosis agent.
Definition
ChEBI: N,N'-(hexane-1,6-diyl)bis(1-{(2S)-2-cyclohexyl-2-[(N-methyl-L-alanyl)amino]acetyl}-L-prolyl-beta-phenyl-L-phenylalaninamide) is a polyamide consisting of hexane-1,6-diamine having a 1-{(2S)-2-cyclohexyl-2-[(N-methyl-L-alanyl)amino]acetyl}-L-prolyl-beta-phenyl-L-phenylalanyl moiety attached to both nitrogens. It is functionally related to a methyl 1-{(2S)-2-cyclohexyl-2-[(N-methyl-L-alanyl)amino]acetyl}-L-prolyl-beta-phenyl-L-phenylalaninate.