URMC-099
- Product Name
- URMC-099
- CAS No.
- 1229582-33-5
- Chemical Name
- URMC-099
- Synonyms
- RMC099;CS-1776;URMC-099;URMC-099;URMC 099;inhibit,MLKs,Autophagy,URMC 099,URMC099,URMC-099,Inhibitor,Mixed Lineage Kinase;3-(1H-indol-5-yl)-5-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridine;1H-?Pyrrolo[2,?3-?b]?pyridine, 3-?(1H-?indol-?5-?yl)?-?5-?[4-?[(4-?methyl-?1-?piperazinyl)?methyl]?phenyl]?-;3-(1H-indol-5-yl)-5-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridine URMC-099
- CBNumber
- CB62719728
- Molecular Formula
- C27H27N5
- Formula Weight
- 421.54
- MOL File
- 1229582-33-5.mol
URMC-099 Property
- Density
- 1.256±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (>25 mg/ml)
- form
- solid
- pka
- 13.49±0.40(Predicted)
- color
- Off-white
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Safety
- HS Code
- 2933998090
N-Bromosuccinimide Price
- Product number
- 19147
- Product name
- URMC-099
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $60
- Updated
- 2024/03/01
- Product number
- 19147
- Product name
- URMC-099
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $29
- Updated
- 2022/04/27
- Product number
- 19147
- Product name
- URMC-099
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $99
- Updated
- 2024/03/01
- Product number
- 19147
- Product name
- URMC-099
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $162
- Updated
- 2024/03/01
- Product number
- U842000
- Product name
- URMC-099
- Packaging
- 1mg
- Price
- $105
- Updated
- 2021/12/16
URMC-099 Chemical Properties,Usage,Production
Description
URMC-099 (1229582-33-5) is a potent (IC50 = 14 nM), brain penetrant mixed-lineage kinase 3 inhibitor (MLK3). It also potently inhibits FLT3 (4 nM in vitro, but 560 nM in vivo), LRRK2 (11 nM), and ABL1 (3 nM).1 URMC-099 displayed neuroprotective effects in HIV-associated neurocognitive disorders2 and facilitated microglial amyloid-β degradation and clearance in mouse models.3,4 URMC-099 increased CD8+ T cells in mice and increased the CD8+GZMB+ T cell population in blood mononuclear cells isolated from breast cancer patients.5
Uses
URMC-099 is an orally bioavailable MLK3 inhibitor used in the treatment of Parkinson’s disease and HIV-1 associated neurocognitive disorders.
References
1) Goodfellow et al. (2013), Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3; J. Med. Chem. 56 8032 2) Marker et al. (2013), The new small-molecule mixed-lineage kinase 3 inhibitor URMC-099 is neuroprotective and anti-inflammatory in models of human immunodeficiency virus-associated neurocognitive disorders; J. Neurosc. 33 9998 3) Dong et al. (2016), The mixed-lineage kinase 3 inhibitor URMC-099 facilitates microglial amyloid-β degradation; J. Neuroinflammation 13 184 4) Kiyota et al. (2018), URMC-099 facilitates amyloid-β clearance in a murine model of Alzheimer’s disease; J. Neuroinflammation 15 137 5) Kumar et al. (2020), Mixed lineage kinase 3 inhibition induces T cell activation and cytotoxicity; Proc. Natl. Acad. Sci. USA 9 34567
URMC-099 Preparation Products And Raw materials
Raw materials
Preparation Products
URMC-099 Suppliers
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