ChemicalBook > CAS DataBase List > CX6258(HCL)

CX6258(HCL)

Product Name: CX6258(HCL)
CAS No.: 1353859-00-3
Chemical Name: CX6258(HCL)
Synonyms: CX6285;CX6258(HCL);CX-6258 Hydrochloride;CX6258(HCL) USP/EP/BP;Pim-Kinase Inhibitor X;CX-6258 hydrochloride, 10 mM in DMSO;CX6258 hydrochloride PIM inhibitor CX-6258 HCL;CX6258 hydrochloride,Pim,CX6258,CX-6258,Pim kinases,4E-BP1,CX 6258 hydrochloride,Inhibitor,CX 6258,Bad,inhibit;(E)-5-Chloro-3-((5-(3-(4-methyl-1,4-diazepane-1-carbonyl)phenyl)furan-2-yl)methylene)indolin-2-one hydrochloride;(3E)-5-chloro-3-[[5-[3-[(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)carbonyl]phenyl]-2-furanyl]methylene]-1,3-dihydro-2H-Indol-2-one, hydrochloride (1:1)
CBNumber: CB62729105
Molecular Formula: C26H25Cl2N3O3
Formula Weight: 498.4
MOL File: 1353859-00-3.mol

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CX6258(HCL) Property

storage temp.: Inert atmosphere,Room Temperature
solubility: DMSO:57.0(Max Conc. mg/mL);114.37(Max Conc. mM)
Ethanol:1.0(Max Conc. mg/mL);2.01(Max Conc. mM)
form: Solid
color: Orange to red

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: C858800
Product name: CX-6258
Packaging: 5mg
Price: $150
Updated: 2021/12/16

TRC

Product number: C858800
Product name: CX-6258
Packaging: 25mg
Price: $595
Updated: 2021/12/16

AK Scientific

Product number: 2343AH
Product name: (E)-5-Chloro-3-((5-(3-(4-methyl-1,4-diazepane-1-carbonyl)phenyl)furan-2-yl)methylene)indolin-2-onehydrochloride
Packaging: 1mg
Price: $104
Updated: 2021/12/16

AK Scientific

Product number: 2343AH
Product name: (E)-5-Chloro-3-((5-(3-(4-methyl-1,4-diazepane-1-carbonyl)phenyl)furan-2-yl)methylene)indolin-2-onehydrochloride
Packaging: 25mg
Price: $304
Updated: 2021/12/16

Axon Medchem

Product number: Axon2305
Product name: CX6258hydrochloride
Purity: 99%
Packaging: 25mg
Price: $352
Updated: 2021/12/16

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CX6258(HCL) Chemical Properties,Usage,Production

Uses

CX-6258 HCl is a potent, orally efficacious pan-Pim kinase inhibitor.

in vivo

CX-6258 (50-100 mg/kg; p.o; daily; over a period of 21 days) exhibits robust in vivo efficacy in two Pim kinases driven tumor models^[1].

Animal Model:	Nude mice, MV-4-11 xenograft models^[1]
Dosage:	50 mg/kg, 100 mg/kg.
Administration:	Oral administration; once daily; over a period of 21 days.
Result:	Exhibitd dose dependent efficacy, with a 50 mg/kg dose producing 45% tumor growth inhibition (TGI) and a 100 mg/kg dose producing 75% TGI.

CX6258(HCL) Preparation Products And Raw materials

Raw materials

Preparation Products

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1353859-00-3, CX6258(HCL)Related Search:

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CX6258(HCL)

(3E)-5-chloro-3-[[5-[3-[(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)carbonyl]phenyl]-2-furanyl]methylene]-1,3-dihydro-2H-Indol-2-one, hydrochloride (1:1)

CX6258(HCL) 2H-Indol-2-one, 5-chloro-3-[[5-[3-[(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)carbonyl]phenyl]-2-furanyl]methylene]-1,3-dihydro-, hydro

CX-6258 Hydrochloride

CX6285

Pim-Kinase Inhibitor X

CX6258(HCL) USP/EP/BP

(E)-5-Chloro-3-((5-(3-(4-methyl-1,4-diazepane-1-carbonyl)phenyl)furan-2-yl)methylene)indolin-2-one hydrochloride

CX6258 hydrochloride PIM inhibitor CX-6258 HCL

CX6258 hydrochloride,Pim,CX6258,CX-6258,Pim kinases,4E-BP1,CX 6258 hydrochloride,Inhibitor,CX 6258,Bad,inhibit

CX-6258 hydrochloride, 10 mM in DMSO

1353859-00-3

C26H24ClN3O3HCl

Inhibitors