SGI-1776
- Product Name
- SGI-1776
- CAS No.
- 1025065-69-3
- Chemical Name
- SGI-1776
- Synonyms
- CS-504;I-1776;SGI-1776;S I-1776;SGI-1776, >=98%;SGI-1776;SGI1776;I-1776 free base;SGI-1776 free base;SGI-1776 USP/EP/BP;Pim-Kinase Inhibitor IX
- CBNumber
- CB82561495
- Molecular Formula
- C20H22F3N5O
- Formula Weight
- 405.42
- MOL File
- 1025065-69-3.mol
SGI-1776 Property
- Density
- 1.37
- storage temp.
- Store at -20°C
- solubility
- ≥40.5 mg/mL in DMSO; insoluble in H2O; ≥101 mg/mL in EtOH
- pka
- 9.22±0.10(Predicted)
- form
- Solid
- color
- White to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 16423
- Product name
- SGI-1776
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 16423
- Product name
- SGI-1776
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $139
- Updated
- 2024/03/01
- Product number
- 16423
- Product name
- SGI-1776
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $214
- Updated
- 2024/03/01
- Product number
- 16423
- Product name
- SGI-1776
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $759
- Updated
- 2024/03/01
- Product number
- 474186
- Product name
- SGI-1776
- Packaging
- 100mg
- Price
- $1677
- Updated
- 2021/12/16
SGI-1776 Chemical Properties,Usage,Production
Uses
A novel, ATP competitive inhibitor of Pim1, Pim2 and Pim3 with IC50s of 7 nM, 363 nM and 69 nM, respectively.
Uses
SGI-1776 is a Pim-1 kinase inhibitor. Potent PIM inhibitor.
Definition
ChEBI: N-[(1-methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]-6-imidazo[1,2-b]pyridazinamine is a member of imidazoles.
Biological Activity
sgi-1776 free base, n-((1-methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine, is a potent atp-competitive inhibitor of the serine/threonine family of pim kinase, an enzyme regulating cell survival. through extensive biomedical characterization, sgi-1776 exhibits specificity to the three isoforms of the pim family, including pim-1, pim-2, and pim-3. according to preliminary results from studies treating prostate cancer cells, sgi-1776 dose-dependently reduces phosphorylation of known pim kinase substrates involved in cell cycle progression and apotosis (p21cip1/waf1 and bad), compromises overall cell viability by inducing g1 cell cycle arrest and triggering apoptosis, and reduces cell viability in a multidrug resistance 1 (mdr1) protein based taxane-refractory prostate cancer cell line.shannon m. mumenthaler, patricia y.b. ng, amanda hodge, davide bearss, gregory berk, sarath kanekal, sanjeev redkar, pietro taverna, davide b. agus, and anjali jain. pharmacological inhibition of pim kinases alters prostate cancer cell growth and resensitizes chemoresistant cells to taxanes. mol cancer ther. 2009; 8(10): 2882-2893lisa s. chen, s anjeev redkar, david bearss, william g. wierda and varsha gandhi. pim kinase inhibitor, sgi-1776, induces apoptosis in cll lymphocytes. blood. 2009; 114(19): 4150-4157
target
Pim1
SGI-1776 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from SGI-1776 manufacturers
- Product
- SGI-1776 1025065-69-3
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2020-01-10
- Product
- SGI-1776 1025065-69-3
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-10