SGI-1776

Product Name: SGI-1776
CAS No.: 1025065-69-3
Chemical Name: SGI-1776
Synonyms: CS-504;I-1776;SGI-1776;S I-1776;SGI-1776, >=98%;SGI-1776;SGI1776;I-1776 free base;SGI-1776 free base;SGI-1776 USP/EP/BP;Pim-Kinase Inhibitor IX
CBNumber: CB82561495
Molecular Formula: C20H22F3N5O
Formula Weight: 405.42
MOL File: 1025065-69-3.mol

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SGI-1776 Property

Density: 1.37
storage temp.: Store at -20°C
solubility: ≥40.5 mg/mL in DMSO; insoluble in H2O; ≥101 mg/mL in EtOH
pka: 9.22±0.10(Predicted)
form: Solid
color: White to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 16423
Product name: SGI-1776
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 16423
Product name: SGI-1776
Purity: ≥98%
Packaging: 5mg
Price: $139
Updated: 2024/03/01

Cayman Chemical

Product number: 16423
Product name: SGI-1776
Purity: ≥98%
Packaging: 10mg
Price: $214
Updated: 2024/03/01

Cayman Chemical

Product number: 16423
Product name: SGI-1776
Purity: ≥98%
Packaging: 50mg
Price: $759
Updated: 2024/03/01

TRC

Product number: S282380
Product name: SGI-1776
Packaging: 5mg
Price: $130
Updated: 2021/12/16

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SGI-1776 Chemical Properties,Usage,Production

Uses

A novel, ATP competitive inhibitor of Pim1, Pim2 and Pim3 with IC50s of 7 nM, 363 nM and 69 nM, respectively.

Uses

SGI-1776 is a Pim-1 kinase inhibitor. Potent PIM inhibitor.

Definition

ChEBI: N-[(1-methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]-6-imidazo[1,2-b]pyridazinamine is a member of imidazoles.

Biological Activity

sgi-1776 free base, n-((1-methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine, is a potent atp-competitive inhibitor of the serine/threonine family of pim kinase, an enzyme regulating cell survival. through extensive biomedical characterization, sgi-1776 exhibits specificity to the three isoforms of the pim family, including pim-1, pim-2, and pim-3. according to preliminary results from studies treating prostate cancer cells, sgi-1776 dose-dependently reduces phosphorylation of known pim kinase substrates involved in cell cycle progression and apotosis (p21cip1/waf1 and bad), compromises overall cell viability by inducing g1 cell cycle arrest and triggering apoptosis, and reduces cell viability in a multidrug resistance 1 (mdr1) protein based taxane-refractory prostate cancer cell line.shannon m. mumenthaler, patricia y.b. ng, amanda hodge, davide bearss, gregory berk, sarath kanekal, sanjeev redkar, pietro taverna, davide b. agus, and anjali jain. pharmacological inhibition of pim kinases alters prostate cancer cell growth and resensitizes chemoresistant cells to taxanes. mol cancer ther. 2009; 8(10): 2882-2893lisa s. chen, s anjeev redkar, david bearss, william g. wierda and varsha gandhi. pim kinase inhibitor, sgi-1776, induces apoptosis in cll lymphocytes. blood. 2009; 114(19): 4150-4157

Synthesis

7149-42-0

928337-00-2

1025065-69-3

12. Scheme for the synthesis of 7-29. Scheme 6: 13. Synthesis of N-((1-methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine (Compound 7-29):[0148] Under the protection of argon, 6-chloro-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazinium (40 mg, 0.128 mmol ), (1-methylpiperidin-4-yl)methylamine (24.53 mg, 0.191 mmol), ligand (7.53 mg, 0.019 mmol), Pd2(dba)3 (9.56 mg, 0.010 mmol) and NaOtBu (17.40 mg, 0.181 mmol) were dissolved in toluene (5 mL). The reaction mixture was degassed for 10 minutes and then heated to reflux for 12 hours. Upon completion of the reaction, the crude product was concentrated and purified by preparative thin layer chromatography (TLC) using 10% MeOH/DCM as eluent to give 17.6 mg of the target product 7-29 in 50% yield.

in vivo

SGI-1776 free base (75, 200 mg/kg, p.o.) shows potent and sustained antitumor activity in a dose dependent manner in MV-4-11 xenografts in mice^[4].

target

Pim1

References

[1] Patent: WO2008/58126, 2008, A2. Location in patent: Page/Page column 54-55

SGI-1776 Preparation Products And Raw materials

Raw materials

Preparation Products

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SGI-1776 Suppliers

China 155 India 2 United Kingdom 1 United States 21 Global 179

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
Advantage: 61

Jinan Trio PharmaTech Co., Ltd.

Tel: 0531-88811783
Fax: +86 (531) 55696010 QQ 1762738062
Email: sales@trio-pharmatech.com
Country: China
ProdList: 1856
Advantage: 62

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4747
Advantage: 58

Shanghai civi chemical technology co.,Ltd

Tel: 86-21-34053660
Fax: 86-21-34053661
Email: sale@labgogo.com
Country: China
ProdList: 9865
Advantage: 52

NCE Biomedical Co.,Ltd.

Tel: 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax: +86-27-87599188
Country: China
ProdList: 1493
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Shanghai T&W Pharmaceutical Co., Ltd.

Tel: +86 21 61551611
Fax: +86 21 50676805
Country: China
ProdList: 9891
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Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
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Wuhan Kaymke Chemical Co., Ltd.,

Tel: 027-027-87342388 18086026008
Fax: 027-87342388
Email: sales@kaymke.com
Country: China
ProdList: 3732
Advantage: 55

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View Lastest Price from SGI-1776 manufacturers

Career Henan Chemical Co

Product: SGI-1776 1025065-69-3
Price: US $1.00/g
Min. Order: 1g
Purity: 95-99%
Supply Ability: 1ton
Release date: 2020-01-10

Career Henan Chemical Co

Product: SGI-1776 1025065-69-3
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200kg
Release date: 2020-01-10

1025065-69-3, SGI-1776Related Search:

SGI 7079 SGI-1027 Imidazo[4,5,1-jk][1,4]benzodiazepin-7(4H)-one, 2-[4-[(dimethylamino)methyl]phenyl]-5,6-dihydro- CX6258(HCL) (5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione A-674563 AZD-1208 BEZ235 (NVP-BEZ235, Dactolisib)

N-((1-methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine

N-[(1-Methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]-imidazo[1,2-b]pyridazin-6-amine SGI-1776

SGI-1776

SGI-1776 free base

N-[(1-Methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]-imidazo[1,2-b]pyridazin-6-amine

SGI-1776, >=98%

SGI-1776 free base N-[(1-Methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]-imidazo[1,2-b]pyridazin-6-amine

SGI-1776 FREE BASE;SGI1776

N-[(1-Methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]-imidazo[1,2-b]pyridazin-6-am

SGI-1776 free base1025065-69-3

SGI-1776;SGI1776

CS-504

Pim-Kinase Inhibitor IX

I-1776

I-1776 free base

Imidazo[1,2-b]pyridazin-6-amine, N-[(1-methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]-

SGI-1776 USP/EP/BP

S I-1776

SGI-1776, 10 mM in DMSO

SGI-1776 free base ，S2198

1025065-69-3

C20H22F3N5O

Inhibitors

JAK

STAT

Inhibitor

JAK/STAT