PFI3

Product Name: PFI3
CAS No.: 1819363-80-8
Chemical Name: PFI3
Synonyms: PFI3;PFI-3;CS-1803;PFI3; PFI 3;PFI3 USP/EP/BP;Inhibitor,Epigenetic Reader Domain,PFI3,PFI-3,inhibit;(2E)-1-(2-Hydroxyphenyl)-3-[(1R,4R)-5-(2-pyridinyl)-2,5-diazabicyclo[2.2.1]hept-2-yl]-2-propen-1-one;(E)-1-(2-Hydroxyphenyl)-3-((1R,4R)-5-(pyridin-2-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)prop-2-en-1-one;(2E)-1-(2-Hydroxyphenyl)-3-[(1R,4R)-5-(pyridin-2-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl]prop-2-en-1-one;2-Propen-1-one, 1-(2-hydroxyphenyl)-3-[(1R,4R)-5-(2-pyridinyl)-2,5-diazabicyclo[2.2.1]hept-2-yl]-, (2E)-
CBNumber: CB62729372
Molecular Formula: C19H19N3O2
Formula Weight: 321.37
MOL File: 1819363-80-8.mol

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PFI3 Property

storage temp.: 2-8°C
solubility: Soluble in DMSO (>25 mg/ml)
form: powder
color: yellow to orange
Stability:: Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0939
Product name: PFI-3
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $113
Updated: 2023/06/20

Sigma-Aldrich

Product number: SML0939
Product name: PFI-3
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $453
Updated: 2023/06/20

Cayman Chemical

Product number: 15267
Product name: PFI-3
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 15267
Product name: PFI-3
Purity: ≥98%
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 15267
Product name: PFI-3
Purity: ≥98%
Packaging: 10mg
Price: $169
Updated: 2024/03/01

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PFI3 Chemical Properties,Usage,Production

Description

PFI-3 (1819363-80-8) is a selective inhibitor of family VIII bromodomains PB1(5), SMARCA2, and SMARCA4.1 It showed complete selectivity over all non-family VIII bromodomains.? PFI-3 blocked adipogenesis in C3H10T1/2 mesenchymal cells at 20μM.Treatment of embryonic stem cells with PFI-3 led to deprivation of stemness and deregulated lineage specificity. Differentiation of trophoblast stem cells in the presence of PFI-3 was enhanced.2 Cell permeable.

Uses

PFI-3 is a selective chemical inhibitor for SMARCA (2/4) and PBI (5) bromodomains which may result in the delay and prevention of breast cancer.

Definition

ChEBI: PFI-3 is an azabicycloalkane that is (1R,4R)-2,5-diazabicyclo[2.2.1]heptane which is substituted at position 2 by a 3-(2-hydroxyphenyl)-3-oxoprop-1-en-1-yl group and at position 5 by a pyridin-2-yl group. It is a potent and selective inhibitor of polybromo 1 (Kd = 48 nM), SMARCA2 and SMARCA4 (Kd = 89 nM) bromodomains. It is a member of pyridines, an azabicycloalkane, a member of phenols and an enone.

Biochem/physiol Actions

SMARCA4 (SWI/SNF related, Matrix associated, Actin dependent Regulator of Chromatin, subfamily A, member 4) is a transcriptional activator and is a component of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. SMARC4 (also known as BRG1) and the related protein SMARCA2 (also known as BRM) contain a bromodomain that is structurally similar to the PolyBromo1 (PB1) 5 bromodomain. PFI-3 is a selective chemical probe for SMARCA bromodomains that inhibits SMARCA2, SMARCA4 and PB1(5) bromodomains. For full characterization details, please visit the PFI-3 probe summary on the Structural Genomics Consortium (SGC) website.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

storage

Store at -20°C

References

Gerstenberger et al. (2016), Identification of a chemical probe for family VIII bromodomains through optimization of a fragment hit; J. Med. Chem. 59 4800 Fedorov et al. (2015), Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance; Sci. Adv. 1 e1500723

PFI3 Preparation Products And Raw materials

Raw materials

Preparation Products

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PFI3 Suppliers

China 73 India 1 United Kingdom 1 United States 13 Global 88

Target molecule Corp.

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TargetMol Chemicals Inc.

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InvivoChem

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Cckinase, Inc.

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Email: sales@cckinase.com
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BOC Sciences

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Email: inquiry@bocsci.com
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Aladdin Scientific

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TargetMol Chemicals Inc.

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ApexBio Technology

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BOC Sciences

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Focus Biomolecules

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Cayman Chemical Company

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United States Biological

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Riedel-de Haen AG

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1819363-80-8, PFI3Related Search:

RESINIFERATOXIN Tigecycline 9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one Elafibranor(GFT505) UNC 669 Bortezomib CAY10683 (SantacruzaMate A) LCL-161 6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE OF-1

PFI3; PFI 3

CS-1803

(2E)-1-(2-Hydroxyphenyl)-3-[(1R,4R)-5-(pyridin-2-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl]prop-2-en-1-one

PFI3

PFI-3

(E)-1-(2-Hydroxyphenyl)-3-((1R,4R)-5-(pyridin-2-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)prop-2-en-1-one

(2E)-1-(2-Hydroxyphenyl)-3-[(1R,4R)-5-(2-pyridinyl)-2,5-diazabicyclo[2.2.1]hept-2-yl]-2-propen-1-one

2-Propen-1-one, 1-(2-hydroxyphenyl)-3-[(1R,4R)-5-(2-pyridinyl)-2,5-diazabicyclo[2.2.1]hept-2-yl]-, (2E)-

PFI3 USP/EP/BP

Inhibitor,Epigenetic Reader Domain,PFI3,PFI-3,inhibit

1819363-80-8

1819363-80-0

Inhibitors