Clobetasol propionate

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Clobetasol propionate

Mechanism of Action Indications

Product Name: Clobetasol propionate
CAS No.: 25122-46-7
Chemical Name: Clobetasol propionate
Synonyms: CLOBETASOLE PROPIONATE;Olux;Clobex;Temovate;CLOBETASOL-17-PROPIONATE;Psorex;Olux-E;cgp9555;GR-2/92;Karison
CBNumber: CB6274337
Molecular Formula: C25H32ClFO5
Formula Weight: 466.97
MOL File: 25122-46-7.mol

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Clobetasol propionate Property

Melting point:: 195.5-1970C
alpha: D +103.8° (c = 1.04 in dioxane)
Boiling point:: 569.0±50.0 °C(Predicted)
Density: 1.1653 (estimate)
storage temp.: Keep in dark place,Sealed in dry,2-8°C
solubility: Practically insoluble in water, freely soluble in acetone, sparingly soluble in ethanol (96 per cent).
pka: 12.88±0.70(Predicted)
form: Solid
color: White to off-white
InChI: InChI=1/C25H32ClFO5/c1-5-21(31)32-25(20(30)13-26)14(2)10-18-17-7-6-15-11-16(28)8-9-22(15,3)24(17,27)19(29)12-23(18,25)4/h8-9,11,14,17-19,29H,5-7,10,12-13H2,1-4H3/t14-,17-,18-,19-,22-,23-,24-,25-/s3
InChIKey: CBGUOGMQLZIXBE-XGQKBEPLSA-N
SMILES: O([C@@]1([C@H](C[C@@]2([H])[C@]3([H])CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C)C)C(=O)CCl)C(=O)CC |&1:1,2,4,6,16,18,20,23,r|
CAS DataBase Reference: 25122-46-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,T
Risk Statements: 36/37/38-62-53-48/20/21-61
Safety Statements: 26-36-45-36/37-53
WGK Germany: 2
RTECS: TU3725000
HS Code: 29372290

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H373May cause damage to organs through prolonged or repeated exposure

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P201Obtain special instructions before use.

P273Avoid release to the environment.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C8037
Product name: Clobetasol propionate
Purity: analytical standard
Packaging: 1g
Price: $363
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1138405
Product name: Clobetasol propionate
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $436
Updated: 2024/03/01

Cayman Chemical

Product number: 21251
Product name: Clobetasol Propionate
Purity: ≥98%
Packaging: 500mg
Price: $36
Updated: 2024/03/01

Cayman Chemical

Product number: 21251
Product name: Clobetasol Propionate
Purity: ≥98%
Packaging: 1g
Price: $63
Updated: 2024/03/01

Sigma-Aldrich

Product number: Y0000559
Product name: Clobetasol propionate
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: y0000559
Price: $220
Updated: 2024/03/01

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Clobetasol propionate Chemical Properties,Usage,Production

Mechanism of Action

Clobetasol Propionate is the propionate salt form of clobetasol, a topical synthetic corticosteroid with anti-inflammatory, anti-pruritic, and vasoconstrictive properties. Clobetasol propionate exerts its effect by binding to cytoplasmic glucocorticoid receptors and subsequently activates glucocorticoid receptor mediated gene expression. This results in the synthesis of certain anti-inflammatory proteins, while inhibiting the synthesis of certain inflammatory mediators. Specifically, clobetasol propionate appears to induce phospholipase A2 inhibitory proteins, thereby controlling the release of the inflammatory precursor arachidonic acid from membrane phospholipids by phospholipase A2.

Indications

Clobetasol propionate is the 17-O-propionate ester of clobetasol and it derives from a clobetasol and a propionic acid. A potent corticosteroid, it is used to treat various skin disorders, including exzema and psoriasis.
Clobetasol propionate was patented in 1968 and came into medical use in 1978. It is available as a generic medication. Clobetasol propionate is used for the treatment of various skin disorders including eczema, herpes labialis, psoriasis, and lichen sclerosus. It is also used to treat several auto-immune diseases, including alopecia areata, lichen planus (auto immune skin nodules), and mycosis fungoides (T-cell skin lymphoma). It is used as first-line treatment for both acute and chronic GVHD of the skin.

Chemical Properties

White or almost white, crystalline powder.

Originator

Dermovate,Glaxo,UK,1973

Uses

Clobetasol-17-propionate is a topical corticosteroid belonging to the group-D (hydrocortisone-q-butyrate) type of steroids.

Uses

For short-term topical treatment of the inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp.

Uses

Topical corticosteroid. Glucocorticoid; anti-inflammatory.

Clobetasol propionate (Cormax, Temovate, Embeline, Olux) is one of the most potent of the currently available agents and is indicated for short-term treatment of inflammatory or hyperplastic disorders. It is a synthetic fluorinated corticosteroid. It may cause a more rapid or prolonged response than other topical corticosteroids. It is recommended that clobetasol have a maximum application of 60 g/week for no longer than 14 days without occlusion and that it should not be used in children below age 12.

Definition

ChEBI: The 17-O-propionate ester of clobetasol. A potent corticosteroid, it is used to treat various skin disorders, including exzema and psoriasis.

Indications

Clobetasol propionate (Cormax, Temovate, Embeline, Olux) is one of the most potent of the currently available agents and is indicated for short-term treatment of inflammatory or hyperplastic disorders. It is a synthetic fluorinated corticosteroid. It may cause a more rapid or prolonged response than other topical corticosteroids. It is recommended that clobetasol have a maximum application of 60 g/week for no longer than 14 days without occlusion and that it should not be used in children below age 12.

Manufacturing Process

A solution of betamethasone 21-methanesulfonate (4 g) in dimethylformamide (25 ml) was treated with lithium chloride (4 g) and the mixture heated on the steam bath for 30 minutes. Dilution with water gave the crude product which was recrystallized to afford the title compound, MP 226°C.
Clobetasol is usually converted to the propionate as the useful form by reaction with propionic anhydride.

brand name

Clobex (Galderma); Clobex (Galderma); Embeline (Healthpoint); Olux (Connetics); Temovate (Altana).

Therapeutic Function

Corticosteroid, Antiinflammatory

Clobetasol propionate Preparation Products And Raw materials

Raw materials

Preparation Products

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Clobetasol propionate Suppliers

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View Lastest Price from Clobetasol propionate manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd

Product: Clobetasol Propionate 25122-46-7
Price: US $150.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 500kg
Release date: 2024-11-25

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Clobetasol propionate 25122-46-7
Price: US $0.00-0.00/KG
Min. Order: 10g
Purity: 97%~102%,USP38
Supply Ability: 50kg
Release date: 2021-05-28

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Product: Clobetasol Propionate 25122-46-7
Price: US $0.00/g
Min. Order: 1g
Purity: More Than 99%
Supply Ability: 100kg/Month
Release date: 2024-09-06

25122-46-7, Clobetasol propionateRelated Search:

Epichlorohydrin Nandrolone phenylpropionate 2-Bromopropionic acid Calcium Propionate 1-chlorotridecane 3-Chloropropyl acetate 6-Chlorohexanol Chloroacetic acid (2-METHYL-1H-INDOL-3-YL)-OXO-ACETIC ACID ETHYL ESTER 1-ACETOXY-3-CHLOROACETONE TRANS-2-FLUOROCYCLOHEXANOL 1-Chlorodecane 1-Chloro-3-ethoxypropane 1-CHLORO-5-METHYLHEXANE 1-Chlorohexadecane 8-Chloro-1-octanol Clobetasol Propionate 25122-46-7 / Base 1-Chlorotetradecane

17-propionate

cgp9555

Clobetasol 17- propionate solution,100ppm

Cloβsol propionate

21-Chloro-9-fluoro-11b,17-dihydroxy-16b-methylpregna-1,4-diene-3,20-dione 17-propionate

CLOBETASOL 17-PROPIONATE USP

[(8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate

Dermovate

GR-2/92

Olux

Psorex

Temovate

CLOBETASOLPROPIONATE,MICRONIZED

CLOBETASOLPROPIONATE,MICRONIZED,USP

21-Chloro-21-deoxybetamethasone 17-propionate

CCl 4725

Clobederm

Dermoval

Dermoxinale

GR 2/925

Pregna-1,4-diene-3,20-dione, 21-chloro-9-fluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)-, (11β,16β)-

Pregna-1,4-diene-3,20-dione, 21-chloro-9-fluoro-11β,17-dihydroxy-16β-methyl-, 17-propionate (8CI)

21-Chloro-9-fluoro-11β,17-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione=17-propionate

21-Chloro-9α-fluoro-11β-hydroxy-16β-methyl-17α-propionyloxy-1,4-pregnadiene-3,20-dione

Propionic acid clobetasol

Clobetasol Propionate (200 mg)

21-Chloro-9-fluoro-11b,17-dihydroxy-16b-methylpregna-1,4-diene-3,20-d

propanoic acid [(9R,17R)-17-(2-chloro-1-oxoethyl)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] ester

clobesol

pregna-1,4-diene-3,20-dione,21-chloro-9-fluoro-11-beta,17-dihydroxy-16-beta-me

CLOBESTASOL PROPIONATE

CLOBETASOL-17-PROPIONATE

CLOBETASOLE PROPIONATE

CLOBETASOL PROPIONATE

21-chloro-9-fluoro-11beta,17-dihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-propionate

Pregna-1,4-Diene-3,20-Dione,21-Chloro-9-Fluoro-11-Hydroxy-16-Methyl-17-(1-Oxopropoxy)-,(11Beta,16Beta)-

Clobetasolpropionatmikron.

Karison

Olux-E

Skin Cap

(11β,16β)-21-chloro-9-fluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)-pregna-1,4-diene-3,20-dione

21-Chloro-9-fluoro-11b

Clobetasol Propionate (200 mg)F2C309980ug/mg(ai)

Clobetasol Propionate-d5

21-Chloro-9alpha-fluoro-11beta,17alpha-dihydroxy-16beta-methyl-1,4-pregnadiene-3,20-dione 17-Propionate

Clobex

Clobetasol Propionate 25122-46-7

Skin Disease Corticosteroids Raw Powder Clobetasol Propionate 25122-46-7

Clobetasol propionate CRS

Clobetasol Propionate RS

Cloβsol17-Propionate&gt

Clobetasol for peak identification CRS

obetasoL

21-Chloro-9-fluoro-11β,17-dihydroxy-16β-Methylpregn-4-ene-3,20-dione 17-Propionate

Clobetasol-[d5] 17-propionate

Clobetasol propionate USP/EP/BP

Clobetazole propionate

Clobetasol for peak identification (Y0000570)