Spermine
- Product Name
- Spermine
- CAS No.
- 71-44-3
- Chemical Name
- Spermine
- Synonyms
- SPERMINE TETRAHYDROCHLORIDE;Spermin;NEURIDINE HYDROCHLORIDE;MUSCULAMINE HYDROCHLORIDE;DJtPAT;Spermine;NSC 268508;Spermine,97%;Spermine >98%;SOYASAPONIN IV(SH)
- CBNumber
- CB6275334
- Molecular Formula
- C10H26N4
- Formula Weight
- 202.34
- MOL File
- 71-44-3.mol
Spermine Property
- Melting point:
- 28-30 (lit.)
- Boiling point:
- 150 °C/5 mmHg (lit.)
- Density
- 0.937
- refractive index
- 1.4850 (estimate)
- Flash point:
- >230 °F
- storage temp.
- 2-8°C
- solubility
- H2O: 1 M at 20 °C, clear, colorless
- form
- powder
- pka
- 10.88±0.19(Predicted)
- Water Solubility
- Soluble in chloroform, methanol, water and lower alcohols. Insoluble in ether, benzene and petroleum ether.
- Sensitive
- Air Sensitive & Hygroscopic
- Merck
- 14,8743
- BRN
- 1751791
- Stability:
- Hygroscopic
- InChIKey
- PFNFFQXMRSDOHW-UHFFFAOYSA-N
- LogP
- -0.543 (est)
- CAS DataBase Reference
- 71-44-3(CAS DataBase Reference)
- NIST Chemistry Reference
- Spermine(71-44-3)
- EPA Substance Registry System
- 1,4-Butanediamine, N,N'-bis(3-aminopropyl)- (71-44-3)
Safety
- Hazard Codes
- Xi,C
- Risk Statements
- 36/38-34
- Safety Statements
- 26-36-45-36/37/39-27
- RIDADR
- UN 3259 8/PG 2
- WGK Germany
- 3
- RTECS
- EJ7230000
- F
- 3-10
- TSCA
- Yes
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 29212900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
H318Causes serious eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 85590
- Product name
- Spermine
- Purity
- ≥99.0% (GC)
- Packaging
- 5g
- Price
- $321
- Updated
- 2024/03/01
- Product number
- 55513
- Product name
- Spermine
- Purity
- analytical standard
- Packaging
- 100mg
- Price
- $73.6
- Updated
- 2024/03/01
- Product number
- L19562
- Product name
- Spermine, 97%
- Packaging
- 1g
- Price
- $58.9
- Updated
- 2024/03/01
- Product number
- L19562
- Product name
- Spermine, 97%
- Packaging
- 5g
- Price
- $188
- Updated
- 2024/03/01
- Product number
- 18041
- Product name
- Spermine
- Purity
- ≥95%
- Packaging
- 1g
- Price
- $37
- Updated
- 2024/03/01
Spermine Chemical Properties,Usage,Production
Description
Spermine is an endogenous polyamine synthesized from the reaction of spermidine with decarboxylated S-adenosylmethionine in the presence of the enzyme spermine synthase and is required for eukaryotic cell growth and protein synthesis. Intracellular spermine blocks inward rectifying K+ channels, whereas extracellular spermine acts as a mixed NMDA glutamate receptor agonist/antagonist at the polyamine site. Spermine has neuroprotective and anti-inflammatory effects and functions as a free radical scavenger to prevent DNA damage by reactive oxygen species.
Chemical Properties
White to slightly off-white powder crysta
Uses
immune modulator
Uses
Binds to the polyamine modulatory site of NMDA Spermine is essential for both normal and neoplastic tissue growth. It is involved in the modulation of calcium-dependent immune processes. It plays an important role in cellular proliferation and differentiation as well as inhibits neuronal nitric oxide synthase (nNOS).
Uses
Biogenic polyamine formed from spermidine and occurring in almost all tissues. Essential for both normal and neoplastic tissue growth. Involved in the modulation of calcium-dependent immune processes
Definition
ChEBI: A polyazaalkane that is tetradecane in which the carbons at positions 1, 5, 10 and 14 are replaced by nitrogens. Spermine has broad actions on cellular metabolism.
General Description
Spermine?is a polyamine, which functions as a free radical scavenger. It modulates gene expression, chromatin stabilization and prevents DNA damage. Spermine inhibits endonuclease-mediated DNA fragmentation.
Biochem/physiol Actions
Mixed NMDA glutamate receptor agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
storage
+4°C (desiccate)
References
[1] fakler b, brndle u, glowatzki e, et al. strong voltage-dependent inward rectification of inward rectifier k+ channels is caused by intracellular spermine[j]. cell, 1995, 80(1): 149-154.
[2] til h p, falke h e, prinsen m k, et al. acute and subacute toxicity of tyramine, spermidine, spermine, putrescine and cadaverine in rats[j]. food and chemical toxicology, 1997, 35(3): 337-348.
Spermine Suppliers
- Tel
- 0512-69561956 18015581618
- sales@uugene.com
- Country
- China
- ProdList
- 86
- Advantage
- 55
- Tel
- 400-40099585555 17737402800
- 308234779@qq.com
- Country
- China
- ProdList
- 19
- Advantage
- 58
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 4006608290; 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40241
- Advantage
- 62
- Tel
- 821-50328103-801 18930552037
- Fax
- 86-21-50328109
- 3bsc@sina.com
- Country
- China
- ProdList
- 15848
- Advantage
- 69
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30132
- Advantage
- 84
- Tel
- 0757-86329057 18501085097
- Fax
- 010-89508210
- sales3.gd@hwrkchemical.com
- Country
- China
- ProdList
- 7583
- Advantage
- 55
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44751
- Advantage
- 61
- Tel
- 010-82967028 13552068683
- Fax
- +86-10-82967029
- 2355560935@qq.com
- Country
- China
- ProdList
- 12458
- Advantage
- 60
- Tel
- 400-6009262 16621234537
- Fax
- 021-64823266
- zhangsn@titansci.com
- Country
- China
- ProdList
- 14113
- Advantage
- 59
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32344
- Advantage
- 50
- Tel
- Fax
- E-Mail Inquiry
- info@syntechem.com
- Country
- China
- ProdList
- 12990
- Advantage
- 57
- Tel
- 400-1166-196 18981987031
- Fax
- 028-84555506 800101999
- cdhxsj@163.com
- Country
- China
- ProdList
- 11726
- Advantage
- 57
- Tel
- 86-21-63210123
- Fax
- 86-21-63290778 86-21-63218885
- sj_scrc@sinopharm.com
- Country
- China
- ProdList
- 9823
- Advantage
- 79
- Tel
- 0731-85526065 13308475853
- ivy@hnhbsj.com
- Country
- China
- ProdList
- 4550
- Advantage
- 62
- Tel
- +86 (573) 82222445 (0)18006601000 452520369
- Fax
- +86 (573) 82222643
- sales@maya-r.com
- Country
- China
- ProdList
- 11714
- Advantage
- 57
- Tel
- 021-021-021-67601398-809-809-809 15221380277
- Fax
- 021-57711696
- marketing_china@spectrumchemical.com
- Country
- China
- ProdList
- 9664
- Advantage
- 60
- Tel
- 021-61312847 13636370518
- Fax
- 021-55068248
- shyysw007@163.com
- Country
- China
- ProdList
- 4941
- Advantage
- 60
- Tel
- 800-810-5118
- Fax
- +86-10-84193589
- cnchemical@thermofisher.com
- Country
- China
- ProdList
- 17779
- Advantage
- 75
- Tel
- 010-56205725
- Fax
- 010-65763397
- waley188@sohu.com
- Country
- China
- ProdList
- 12338
- Advantage
- 58
- Tel
- 4009209199
- Fax
- 86-021-52271987
- sales@9dingchem.com
- Country
- China
- ProdList
- 22519
- Advantage
- 55
- Tel
- 18521735133 18521732826;
- Fax
- 021-50323701
- market@aladdin-e.com
- Country
- China
- ProdList
- 25015
- Advantage
- 65
- Tel
- 021-68187180-819 13681683526
- Fax
- 021-68187179
- lchen@syncozymes.com
- Country
- China
- ProdList
- 186
- Advantage
- 55
- Tel
- 021-51320588
- Fax
- 0086-21-51320502
- tauto@tautobiotech.com
- Country
- China
- ProdList
- 3989
- Advantage
- 66
- Tel
- 021-33632979 15002134094
- Fax
- 021-33632979
- marketing@targetmol.com
- Country
- China
- ProdList
- 7934
- Advantage
- 58
- Tel
- 021-33632979
- Fax
- 021-34692979
- info@tsbiochem.com
- Country
- China
- ProdList
- 8073
- Advantage
- 58
- Tel
- 400-1647117 15221909166
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 41438
- Advantage
- 60
- Tel
- 021-54359730 400-008-9730
- Fax
- 021-54353864
- info@chemxyz.com
- Country
- China
- ProdList
- 3993
- Advantage
- 60
- Tel
- 0755-0755-66853366 13670046396
- Fax
- 0755-28363542
- sales@chem-strong.com
- Country
- China
- ProdList
- 17982
- Advantage
- 56
- Tel
- 400-1166-196 13458535857
- Fax
- QQ：800101999
- cdhxsj@163.com
- Country
- China
- ProdList
- 13358
- Advantage
- 58
- Tel
- 400-821-5857 021-64326257
- Fax
- 021-64393586 QQ;2798200800
- credit-chem@foxmail.com
- Country
- China
- ProdList
- 5223
- Advantage
- 58
- Tel
- 021-60345187 13671753212
- Fax
- 021-34702061
- lzz841106@aliyun.com
- Country
- China
- ProdList
- 10287
- Advantage
- 55
- Tel
- 15221275939 15221275939
- Fax
- 021-50706099
- shenlinxing@macklin.cn
- Country
- China
- ProdList
- 15878
- Advantage
- 55
- Tel
- 021-69106960 13701823733
- Fax
- 021-69106780
- 13701823733@163.com
- Country
- China
- ProdList
- 4775
- Advantage
- 60
- Tel
- 13718199399
- Fax
- QQ : 206661479
- holiyangchem@163.com
- Country
- China
- ProdList
- 3387
- Advantage
- 56
- Tel
- 021-69005955 13701776567
- Fax
- 021-69005775
- youpengchem@163.com
- Country
- China
- ProdList
- 4303
- Advantage
- 56
- Tel
- 13708085536
- Fax
- QQ : 121102042
- hanovichem@163.com
- Country
- China
- ProdList
- 3389
- Advantage
- 56
- Tel
- 021-021-69182866 13701855675
- Fax
- 021-69182022
- tongyuanchem@126.com
- Country
- China
- ProdList
- 4331
- Advantage
- 58
- Tel
- 021-33516722 13701817765
- Fax
- 021-33516776
- kaisaichem@163.com
- Country
- China
- ProdList
- 4751
- Advantage
- 58
- Tel
- 021-69515658 ; 69515628 13701998368
- Fax
- 021-69515998
- longrunchem@163.com
- Country
- China
- ProdList
- 3920
- Advantage
- 50
- Tel
- 021-69992220 13701886816
- Fax
- 021-69992237
- roleadchem@163.com
- Country
- China
- ProdList
- 4759
- Advantage
- 50
- Tel
- 021-69185552 13701777608
- Fax
- 021-69186006
- kangtuochem@163.com
- Country
- China
- ProdList
- 4369
- Advantage
- 55
- Tel
- 021-60455363 18019463053
- Fax
- 50966098
- sales@coolpharm.com
- Country
- China
- ProdList
- 12357
- Advantage
- 58
- Tel
- 027-59599241 18871490274
- Fax
- 027-59599241
- 1400878000@qq.com
- Country
- China
- ProdList
- 9972
- Advantage
- 58
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
- Country
- China
- ProdList
- 51471
- Advantage
- 80
- Tel
- 021-61984905-1 18016477331
- synchempharma@aliyun.com
- Country
- China
- ProdList
- 6454
- Advantage
- 55
- Tel
- 021-64340559 13651849907;
- Fax
- 021- 64345308
- xinyu_shi@jwypharmlab.com.cn
- Country
- China
- ProdList
- 12042
- Advantage
- 58
- Tel
- 0371-86658258
- Fax
- 0371-60996044
- info@coreychem.com
- Country
- China
- ProdList
- 10457
- Advantage
- 58
- Tel
- 021-52907766-8042
- Fax
- 021-52906523
- Country
- China
- ProdList
- 9947
- Advantage
- 58
- Tel
- 020-61288194 61288195
- Fax
- 020-61288700
- 505721671@qq.com
- Country
- China
- ProdList
- 3868
- Advantage
- 58
View Lastest Price from Spermine manufacturers
- Product
- Spermine 71-44-3
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.1kg
- Purity
- 99.5%
- Supply Ability
- 1000
- Release date
- 2023-12-29
- Product
- Spermine 71-44-3
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 2000ton
- Release date
- 2023-08-31
- Product
- Spermine 71-44-3
- Price
- US $8.00-3.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-03