ChemicalBook > CAS DataBase List > 1,1-Cyclopropanedicarboxylic acid monomethyl ester

1,1-Cyclopropanedicarboxylic acid monomethyl ester

Product Name
1,1-Cyclopropanedicarboxylic acid monomethyl ester
CAS No.
113020-21-6
Chemical Name
1,1-Cyclopropanedicarboxylic acid monomethyl ester
Synonyms
1-(Methoxycarbonyl)cyclopropane-1-carboxylic acid;1-(methoxycarbonyl)cyclopropanecarboxylic acid;Oliceridine Impurity 23;Cyclopropane-1,1-dicarboxylicacid,Methy;Cyclopropyl -1, 1-diformate mono-tyrosol;113020-21-6;1,1-Cyclopropanedicarboxylic acid-1-methyl e;Monomethyl 1,1-cyclopropyl dicarboxylic acid;CYCLOPROPANE-1,1-DICARBOXYLIC ACID, METHYL ESTER;1,1-CYCLOPROPANEDICARBOXYLIC ACID-1-METHYL ESTER
CBNumber
CB6275637
Molecular Formula
C6H8O4
Formula Weight
144.13
MOL File
113020-21-6.mol
More
Less

1,1-Cyclopropanedicarboxylic acid monomethyl ester Property

Melting point:
47-51°C
Boiling point:
85-87°C/0.2mm
Density 
1.419
Flash point:
104 °C
storage temp. 
Sealed in dry,Room Temperature
form 
crystalline solid
pka
3.37±0.20(Predicted)
color 
White
Water Solubility 
Slightly soluble in water.
InChI
InChI=1S/C6H8O4/c1-10-5(9)6(2-3-6)4(7)8/h2-3H2,1H3,(H,7,8)
InChIKey
IZYOHLOUZVEIOS-UHFFFAOYSA-N
SMILES
C1(C(O)=O)(C(OC)=O)CC1
More
Less

Safety

Hazard Codes 
Xi,T
Risk Statements 
25-52
Safety Statements 
45
RIDADR 
UN2811
HazardClass 
IRRITANT
HS Code 
2917200090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

TRC
Product number
B485993
Product name
1-(methoxycarbonyl)cyclopropane-1-carboxylicacid
Packaging
250mg
Price
$55
Updated
2021/12/16
TRC
Product number
B485993
Product name
1-(methoxycarbonyl)cyclopropane-1-carboxylicacid
Packaging
500mg
Price
$65
Updated
2021/12/16
TRC
Product number
B485993
Product name
1-(methoxycarbonyl)cyclopropane-1-carboxylicacid
Packaging
100mg
Price
$45
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC147198
Product name
Cyclopropane-1,1-dicarboxylic acid, methylester
Packaging
1g
Price
$50
Updated
2021/12/16
AK Scientific
Product number
Y7088
Product name
Cyclopropane-1,1-dicarboxylicacid,methylester
Packaging
1g
Price
$21
Updated
2021/12/16
More
Less

1,1-Cyclopropanedicarboxylic acid monomethyl ester Chemical Properties,Usage,Production

Uses

1,1-Cyclopropanedicarboxylic acid monomethyl ester is used as a pharmaceutical intermediate.

Synthesis

6914-71-2

113020-21-6

1. KOH (42 mg, 0.75 mmol) was added to a methanolic solution of dimethyl cyclopropane-1,1-dicarboxylate (100 mg, 0.63 mmol). 2. The reaction mixture was stirred at room temperature for 4 hours. 3. After completion of the reaction, the solvent was removed by concentration under reduced pressure. 4. The residue was diluted with water and acidified with concentrated hydrochloric acid to pH<2. 5. The acidified aqueous phase was extracted with dichloromethane (3 x 10 mL). 6. The organic phases are combined and dried over anhydrous sodium sulfate. 7. The desiccant was removed by filtration and the filtrate was concentrated under reduced pressure to give cyclopropane-1,1-dicarboxylic acid monomethyl ester (65 mg, 71% yield) as a white solid.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 6, p. 2188 - 2193
[2] Patent: US2009/239848, 2009, A1. Location in patent: Page/Page column 33
[3] Patent: WO2012/74761, 2012, A1. Location in patent: Page/Page column 20-21
[4] Organic Letters, 2011, vol. 13, # 16, p. 4180 - 4183
[5] Patent: EP1577301, 2005, A1. Location in patent: Page/Page column 148

1,1-Cyclopropanedicarboxylic acid monomethyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

1,1-Cyclopropanedicarboxylic acid monomethyl ester Suppliers

China 172 Europe 1 Germany 2 India 4 United Kingdom 4 United States 19 Global 202
Shanghai Yuzhicheng Pharmaceutical Technology Co., Ltd.
Tel
18001856580
Fax
QQ：2415195517
Email
2415195517@qq.com
Country
China
ProdList
44
Advantage
58
Nanjing FuRuisi Medical Technology Co., Ltd.
Tel
025-83221260
Fax
02583221260
Email
renqing401@163.com
Country
China
ProdList
267
Advantage
55
TIANJIN PHARMACN MEDICAL TECHNOLOGY CO.,LTD.
Tel
022-60189726 18812034280
Fax
86-22-60979672
Email
188120342808@163.com
Country
China
ProdList
142
Advantage
61
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
Advantage
56
Beijing Ouhe Technology Co., Ltd
Tel
010-010-82967028 13522913783
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12000
Advantage
60
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9310
Advantage
66
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd.
Tel
21-57721279
Fax
QQ：14057904
Email
sales@shydchem.com.cn
Country
China
ProdList
998
Advantage
56
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11035
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
Jinan Trio PharmaTech Co., Ltd.
Tel
0531-88811783
Fax
+86 (531) 55696010 QQ 1762738062
Email
sales@trio-pharmatech.com
Country
China
ProdList
1856
Advantage
62
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
Advantage
57
Chengdu Green Young Biomedical Technology Co., Ltd.
Tel
86+28-85337952 18081025021
Fax
86+28-85337952
Email
greenyoung@glykj.com
Country
China
ProdList
94
Advantage
62
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9718
Advantage
55
Tianjin Branch Chong pharmaceutical intermediates Co., Ltd.
Tel
022-60116533 13207668525
Fax
022-60979672
Email
saleskc@scipharmacn.com
Country
China
ProdList
603
Advantage
58
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17770
Advantage
75
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9510
Advantage
58
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9891
Advantage
58
Shanghai Jian Chao Chemical Technology Co., Ltd.
Tel
150-2103-5486 18017383231
Fax
qq：2817624287
Email
983544897@qq.com
Country
China
ProdList
9342
Advantage
55
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
22514
Advantage
55
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
Biocompounds Pharmaceutical Inc.
Tel
21-57687675
Fax
+86-21-57687169
Email
yanjie@biocompounds.com
Country
China
ProdList
75
Advantage
62
Tianjin Chempharmatech Co.,Ltd.
Tel
022-66211079 13212288319
Fax
qq1405432731
Email
sales@chempharmatech.com
Country
China
ProdList
915
Advantage
55
Shanghai Chainpharm Bio-medical Technology Co., Ltd.
Tel
+86-021-61727342 13611721451
Fax
021-61294107
Email
chainpharm@163.com
Country
China
ProdList
980
Advantage
58
Shanghai JONLN Reagent Co., Ltd.
Tel
400-0066400 13621662912
Fax
021-55660885
Email
422131432@qq.com
Country
China
ProdList
9979
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
ChongQing Purel Bio-Pharmaceutical Technology Co., Ltd.
Tel
023-89130144 18523560356
Fax
023-67534737
Email
zhyong1011@163.com
Country
China
ProdList
290
Advantage
58
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18333
Advantage
56
Chongqing Xingcan Pharmaceutical Technology Co., Ltd.
Tel
023-13650506873 19923294409
Email
xingcanyaoye@sina.com
Country
China
ProdList
1604
Advantage
58
Chengdu HuaXia Chemical Reagent Co. Ltd
Tel
400-1166-196 13458535857
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
13350
Advantage
58
Modachem Shanghai Co., Ltd
Tel
+86 (0)21 51320687 51371369 1744605818
Fax
+86 (0)21 51371369
Country
China
ProdList
1578
Advantage
58
Hangzhou J&H Chemical Co., Ltd.
Tel
0571-87396432
Fax
0571-87396431
Email
sales@jhechem.com
Country
China
ProdList
14912
Advantage
59
Shanghai HuanChuan Industry Co.,Ltd.
Tel
021-61478794
Fax
021-61478794
Email
sales@hcshhai.com
Country
China
ProdList
9793
Advantage
50
Changzhou Ruibo Biotechnology Co., Ltd.
Tel
0519-81884608 18205027398
Fax
0519-81884608
Email
sales@ruibobio.com
Country
China
ProdList
108
Advantage
56
Cool Pharm, Ltd
Tel
021-60455363 18019463053
Fax
50966098
Email
sales@coolpharm.com
Country
China
ProdList
12346
Advantage
58
AN PharmaTech Co Ltd
Tel
86(21)68097365
Fax
86(21)33321566
Email
sales@anpharma.net
Country
China
ProdList
4891
Advantage
55
Quzhou Rundong Chemical (Technology) Co.
Tel
0570-8789886 18892685668
Fax
0570-8789985
Email
info@rundongchemical.com
Country
China
ProdList
4053
Advantage
60
Struchem Co., Ltd.
Tel
0512-63009836 18994340901
Fax
0512-63006936
Email
helen@struchem.com
Country
China
ProdList
3981
Advantage
60
Nanjing Endesa Bio-tech Co., Ltd.
Tel
025-58862853 18915922038
Fax
+86-025-58862853
Email
sales@endesachem.com
Country
China
ProdList
591
Advantage
58
Chengdu syns Pharmaceutical Co., Ltd.
Tel
028-82093588 18980782991
Fax
(+86) 028-89481917
Email
sales@syns.org
Country
China
ProdList
61
Advantage
55
Codow Chemical Co.,Ltd.
Tel
18620099427
Fax
+86-20-62619665
Email
amy@howeipharm.com
Country
China
ProdList
6687
Advantage
55
Shanghai Haozhixiang Biotechnology Co., Ltd
Tel
526763801 13301653310
Fax
+86-21-51619052
Email
526763801@qq.com
Country
China
ProdList
9274
Advantage
55
Chongqing AoShe Biological Chemical Co., Ltd.
Tel
023-63225655 13320248848
Fax
023-63225655QQ2366581735
Email
2366581735@qq.com
Country
China
ProdList
511
Advantage
55
Lanzhou Angeli Biochemical Technology Co., Ltd.
Tel
0931-8235634 13321316780
Fax
+86(931) 4873122
Email
1455540579@qq.com
Country
China
ProdList
958
Advantage
55
Shanghai Xilong Biochemical Technology Co., Ltd.
Tel
021-52907766-8042
Fax
021-52906523
Country
China
ProdList
9941
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
ChengDu TongChuangYuan Pharmaceutical Co.Ltd
Tel
028-83379370 13880556291
Fax
028-87747383
Email
tcy@tcypharm.com
Country
China
ProdList
7218
Advantage
58
More
Less

View Lastest Price from 1,1-Cyclopropanedicarboxylic acid monomethyl ester manufacturers

Henan Fengda Chemical Co., Ltd
Product
1,1-Cyclopropanedicarboxylic acid monomethyl ester 113020-21-6
Price
US $8.00-2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-24
Career Henan Chemical Co
Product
1,1-Cyclopropanedicarboxylic acid monomethyl ester 113020-21-6
Price
US $1.00/KG
Min. Order
1KG
Purity
95%-99%
Supply Ability
1000kg
Release date
2019-08-26

113020-21-6, 1,1-Cyclopropanedicarboxylic acid monomethyl esterRelated Search:

Folic acid Methyl 2-iodobenzoate Methyl formate Methyl acrylate Tris(trimethylsilyl)phosphate Methyl benzoate Methylparaben Cyclopropane Methyl anthranilate Olibanum oil BUTYL OLEATE Dimethyl succinate Trimethoxymethane Citric acid Ascoric Acid Diethyl 1,1-cyclopropanedicarboxylate 1,1-CYCLOPROPANEDICARBOXYLIC ACID MONOETHYL ESTER Methyl chloroformate

  • Cyclopropane-1,1-dicarboxylic acid Monoethyl ester
  • Cyclopropane-1,1-dicarboxylicacid,Methy
  • CYCLOPROPANE-1,1-DICARBOXYLIC ACID, METHYL ESTER
  • 1,1-CYCLOPROPANEDICARBOXYLIC ACID MONOMETHYL ESTER
  • 1,1-CYCLOPROPANEDICARBOXYLIC ACID-1-METHYL ESTER
  • 1,1-Cyclopropanedicarboxylicacid,monomethylester(9CI)
  • Cyclopropane-1,1-dicarboxylic acid monomethyl ester, 97%
  • 1,1-Cyclopropanedicarboxylic acid-1-methyl e
  • 1-(methoxycarbonyl)cyclopropanecarboxylic acid
  • 1-(Methoxycarbonyl)cyclopropane-1-carboxylic acid
  • 113020-21-6 1,1-Cyclopropanedicarboxylic acid monomethyl ester
  • Cyclopropyl -1, 1-diformate mono-tyrosol
  • <font color="#ff0000">113020-21-6</font>
  • 1-(Methoxycarbonyllcyclopropanecarboxylic acid
  • Monomethyl 1,1-cyclopropyl dicarboxylic acid
  • Oliceridine Impurity 23
  • 113020-21-6
  • CARBOXYLICESTER
  • API intermediates