2'-Bromo-4-chlorophenylacetic acid methyl ester
- Product Name
- 2'-Bromo-4-chlorophenylacetic acid methyl ester
- CAS No.
- 24091-92-7
- Chemical Name
- 2'-Bromo-4-chlorophenylacetic acid methyl ester
- Synonyms
- 2-(2-broMo-4-chlorophenyl)propanoate;Methyl-2-bromo-4-chlorophenylacetate;Methyl a-broMo-4-chlorophenylacetate;Methyl alpha-bromo-4-chlorophenylacetate;Methyl 2-broMo-2-(4-chlorophenyl)acetate;2-BROMO-4-CHLOROPHENYLACETIC ACID METHYL ESTER;Benzeneacetic acid, α-bromo-4-chloro-, methyl ester;Benzeneacetic acid, .alpha.-bromo-4-chloro-, methyl ester
- CBNumber
- CB6278229
- Molecular Formula
- C9H8BrClO2
- Formula Weight
- 263.52
- MOL File
- 24091-92-7.mol
2'-Bromo-4-chlorophenylacetic acid methyl ester Property
- Boiling point:
- 149-152 °C(Press: 16 Torr)
- Density
- 1.567±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- Colorless to light yellow Liquid
- CAS DataBase Reference
- 24091-92-7(CAS DataBase Reference)
Safety
- RIDADR
- 1760
- HazardClass
- 8
- PackingGroup
- Ⅲ
N-Bromosuccinimide Price
- Product number
- M296555
- Product name
- Methyl2-Bromo-2-(4-chlorophenyl)acetate
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 454858
- Product name
- Methyl 2-bromo-4-chlorophenylacetate
- Packaging
- 100mg
- Price
- $305
- Updated
- 2021/12/16
- Product number
- FB69893
- Product name
- 2'-Bromo-4'-chlorophenylacetic acid methyl ester
- Packaging
- 5G
- Price
- $312.5
- Updated
- 2021/12/16
- Product number
- FB69893
- Product name
- 2'-Bromo-4'-chlorophenylacetic acid methyl ester
- Packaging
- 1g
- Price
- $77.5
- Updated
- 2021/12/16
- Product number
- FB69893
- Product name
- 2'-Bromo-4'-chlorophenylacetic acid methyl ester
- Packaging
- 2g
- Price
- $142
- Updated
- 2021/12/16
2'-Bromo-4-chlorophenylacetic acid methyl ester Chemical Properties,Usage,Production
Synthesis
52449-43-1
24091-92-7
General procedure for the synthesis of methyl 2'-bromo-4-chlorophenylacetate from methyl 4-chlorophenylacetate: Methyl 4-chlorophenylacetate (14.6 g, 79.1 mmol), N-bromosuccinimide (14.4 g, 80.7 mmol), and benzoyl peroxide (1.91 g, 7.89 mmol) were dissolved in carbon tetrachloride (100 mL) and heated to reflux for 3 hours. After completion of the reaction, the mixture was cooled to room temperature and diluted by adding hexane (500 mL). The reaction mixture was filtered and the solvent was subsequently evaporated under vacuum. The crude product was purified by silica column chromatography (eluent: ethyl acetate/hexane, 15:85) to afford methyl 2'-bromo-4-chlorophenylacetate as a colorless oil (16.9 g, 63% yield).1H NMR (400 MHz, CDCl3) δ 3.81 (s, 3H, CH3), 5.34 (s, 1H, CH), 7.44 (dd) ), J = 60.4 Hz, J = 8.4 Hz, 4H, ArH).
References
[1] Tetrahedron, 2002, vol. 58, # 51, p. 10113 - 10126
[2] Patent: EP1712235, 2006, A2. Location in patent: Page/Page column 53
[3] Patent: US2004/220179, 2004, A1. Location in patent: Page 34
[4] Journal of Medicinal Chemistry, 1993, vol. 36, # 23, p. 3738 - 3742
[5] Patent: US2003/191190, 2003, A1
2'-Bromo-4-chlorophenylacetic acid methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
2'-Bromo-4-chlorophenylacetic acid methyl ester Suppliers
- Tel
- 400-6009262 16621234537
- Fax
- 021-64823266
- chenyj@titansci.com
- Country
- China
- ProdList
- 14101
- Advantage
- 59
- Tel
- 13524892556
- Fax
- (86) 21 51969655， QQ： 263541193
- sales-cn@potentpharm.com
- Country
- China
- ProdList
- 1011
- Advantage
- 55
- Tel
- +1-510-219-6317
- Fax
- +1-650-486-1361
- sales@hbcchem.com
- Country
- United States
- ProdList
- 10648
- Advantage
- 60
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 021-60455363 18019463053
- Fax
- 50966098
- sales@coolpharm.com
- Country
- China
- ProdList
- 12346
- Advantage
- 58
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 13062833949; 4006653949 4006653949
- Fax
- QQ: 2136646215
- fred.wen@crcorporation.cn
- Country
- China
- ProdList
- 9757
- Advantage
- 58
- Tel
- 025-66061636 18013972705
- Fax
- (3)02557626880
- qqyang@aikonchem.com
- Country
- China
- ProdList
- 15814
- Advantage
- 58
- Tel
- 0531-18763987518 18763987518
- levi@lihengpharm.com
- Country
- China
- ProdList
- 1793
- Advantage
- 58
- Tel
- 021-000000 13917643586;
- admin@jingshipharmatech.com
- Country
- China
- ProdList
- 9856
- Advantage
- 58
View Lastest Price from 2'-Bromo-4-chlorophenylacetic acid methyl ester manufacturers
- Product
- Methyl (2-bromo-4-chlorophenyl)acetate 24091-92-7
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2020-01-09