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5-Bromo-1H-benzimidazole

Product Name
5-Bromo-1H-benzimidazole
CAS No.
4887-88-1
Chemical Name
5-Bromo-1H-benzimidazole
Synonyms
6-bromo-1H-benzo[d]imidazole;5-BROMO-1H-BENZO[D]IMIDAZOLE;5-BROMO-1H-BENZOIMIDAZOLE;5-BROMOBENZIMIDAZOLE;6-Bromobenzimidazole;6-Bromobenzimidazole>5-BROMO-1H-BENZIMIDAZOLE;1H-BenziMidazole, 6-broMo-;5-broMo-1H-1,3-benzodiazole;6-BroMo-1H-benziMidazole 97%
CBNumber
CB6280903
Molecular Formula
C7H5BrN2
Formula Weight
197.03
MOL File
4887-88-1.mol
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5-Bromo-1H-benzimidazole Property

Melting point:
130 °C
Boiling point:
417.4±18.0 °C(Predicted)
Density 
1.770±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
soluble in Methanol
form 
powder to crystal
pka
11.19±0.30(Predicted)
color 
White to Yellow to Orange
InChI
InChI=1S/C7H5BrN2/c8-5-1-2-6-7(3-5)10-4-9-6/h1-4H,(H,9,10)
InChIKey
GEDVWGDBMPJNEV-UHFFFAOYSA-N
SMILES
C1NC2=CC(Br)=CC=C2N=1
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22-36/37/38-36-22
Safety Statements 
22-26-36/37/39
WGK Germany 
3
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
702188
Product name
6-Bromo-1H-benzimidazole
Purity
97%
Packaging
1g
Price
$29.5
Updated
2025/07/31
Sigma-Aldrich
Product number
702188
Product name
6-Bromo-1H-benzimidazole
Purity
97%
Packaging
5g
Price
$118
Updated
2025/07/31
TCI Chemical
Product number
B4458
Product name
6-Bromobenzimidazole
Purity
>98.0%(T)
Packaging
1g
Price
$36
Updated
2025/07/31
TCI Chemical
Product number
B4458
Product name
6-Bromobenzimidazole
Purity
>98.0%(T)
Packaging
5g
Price
$142
Updated
2025/07/31
TRC
Product number
B680413
Product name
5-Bromo-1H-benzo[d]imidazole
Packaging
1g
Price
$75
Updated
2021/12/16
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5-Bromo-1H-benzimidazole Chemical Properties,Usage,Production

Chemical Properties

off-white powder

Uses

5-Bromo-1H-benzimidazole is a key intermediate in the synthesis of various organic compounds, especially in the fields of medicine and chemical research.

Synthesis

1575-37-7

149-73-5

4887-88-1

Step 87a: Synthesis of tert-butyl 5-bromo-1H-benzo[d]imidazole-1-carboxylate (compound 0601-187) To a solution of 4-bromo-1,2-benzenediamine (3 g, 16 mmol) in N,N-dimethylformamide (DMF, 22 mL) was added trimethyl orthoformate (44 mL), which was subsequently concentrated. Concentrated hydrochloric acid (1.5 mL) was added and the reaction mixture was stirred at room temperature for 1 hour. Upon completion of the reaction, the mixture was diluted with deionized water (200 mL) and the pH was adjusted to 7 with saturated aqueous sodium bicarbonate. the reaction mixture was extracted with ethyl acetate (200 mL) and the organic layer was dried with anhydrous sodium sulfate and concentrated under reduced pressure to give 5-bromo-1H-benzo[d]imidazole (3.25 g, 100%) as an off-white solid. lc-MS (mass spectrum): m/z 197 [M + H]+. 1H NMR (400 MHz, DMSO-d6) δ 7.33 (t, J = 8.8 Hz, 1H), 7.55 (dd, J1 = 7.6 Hz, J2 = 40 Hz, 1H), 7.79 (d, J = 47.2 Hz, 1H), 8.26 (s, 1H), 12.61 (d, J = 25.6 Hz, 1H ).

References

[1] Patent: WO2011/130628, 2011, A1. Location in patent: Page/Page column 228
[2] Patent: US2013/102595, 2013, A1. Location in patent: Paragraph 0580; 0581
[3] Patent: JP2015/187145, 2015, A. Location in patent: Paragraph 0493
[4] Patent: US2009/326029, 2009, A1. Location in patent: Page/Page column 33

5-Bromo-1H-benzimidazole Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Bromo-1H-benzimidazole Suppliers

Americas 1 Belgium 1 China 189 Europe 2 France 1 India 5 Japan 1 United Kingdom 4 United States 20 Global 224
KaironKem
Tel
--
Fax
--
Email
info@kaironkem.com
Country
France
ProdList
258
Advantage
60
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View Lastest Price from 5-Bromo-1H-benzimidazole manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
5-Bromo-1H-benzimidazole 4887-88-1
Price
US $1.00-2.10/KG
Min. Order
1KG
Purity
99%
Supply Ability
20000KG
Release date
2024-08-08
Career Henan Chemical Co
Product
5-Bromo-1H-benzimidazole 4887-88-1
Price
US $8.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10MT
Release date
2018-12-21

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