2,4,5-Trifluorophenylacetic acid

Product Name: 2,4,5-Trifluorophenylacetic acid
CAS No.: 209995-38-0
Chemical Name: 2,4,5-Trifluorophenylacetic acid
Synonyms: 2,4,5-Trifluoropheny;2,4,5-Trifluorophenylacetic acid ,99%;RETAG-001;RARECHEM AL BO 0510;2,4,5-Trifluoropheny245;Trifluorophenylacetic Aci;trifluorophenylacetic acid;5-Trifluorophenylacetic acid;2,4,5-trifluoropheylacetic acid;2,4,5-trfluorophenylacetic acid
CBNumber: CB6283207
Molecular Formula: C8H5F3O2
Formula Weight: 190.12
MOL File: 209995-38-0.mol

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2,4,5-Trifluorophenylacetic acid Property

Melting point:: 121-125 °C
Boiling point:: 255.0±35.0 °C(Predicted)
Density: 1.468±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 3.78±0.10(Predicted)
color: White to Off-White
InChI: InChI=1S/C8H5F3O2/c9-5-3-7(11)6(10)1-4(5)2-8(12)13/h1,3H,2H2,(H,12,13)
InChIKey: YSQLGGQUQDTBSL-UHFFFAOYSA-N
SMILES: C1(CC(O)=O)=CC(F)=C(F)C=C1F
CAS DataBase Reference: 209995-38-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 37/38-41
Safety Statements: 26-39
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29163990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 684155
Product name: 2,4,5-Trifluorophenylacetic acid
Purity: 97%
Packaging: 1g
Price: $30.64
Updated: 2024/03/01

Sigma-Aldrich

Product number: 684155
Product name: 2,4,5-Trifluorophenylacetic acid
Purity: 97%
Packaging: 5g
Price: $99.1
Updated: 2024/03/01

TCI Chemical

Product number: T2407
Product name: 2,4,5-Trifluorophenylacetic Acid
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $69
Updated: 2024/03/01

Alfa Aesar

Product number: H26190
Product name: 2,4,5-Trifluorophenylacetic acid, 94%
Packaging: 1g
Price: $48.65
Updated: 2024/03/01

Alfa Aesar

Product number: H26190
Product name: 2,4,5-Trifluorophenylacetic acid, 94%
Packaging: 5g
Price: $146.65
Updated: 2024/03/01

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2,4,5-Trifluorophenylacetic acid Chemical Properties,Usage,Production

Description

2,4,5-Trifluorophenylacetic acid is a fluorophenylacetic acid, which is a valuable intermediate for preparing various pharmacologically active compounds. In particular, trifluorophenylacetic acids are used to prepare inhibitors of the dipeptidyl peptidase-4 enzyme. These medicines are helpful in treating diabetes, in particular type 2 diabetes. One of these active ingredients is Sitagliptin, available commercially under the brand name Januvia, which uses 2,4,5-trifluorophenylacetic acid as a critical intermediate for its synthesis.

Chemical Properties

White to light brown solid

Uses

2,4,5-Trifluorobenzeneacetic Acid is used in the synthesis of EGFR/ErbB-2-kinase inhibitors. Also used in the synthesis of new imidazopyrazinone derivatives as potnetial dipeptidyl peptidase IV inhibitors.

Application

2,4,5-Trifluorophenylacetic acid is used to synthesize the intermediate of sitagliptin, a new drug for the treatment of type II diabetes. sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor newly launched by Merck. It has good curative effect, small side effects, good safety and tolerance in treating type II diabetes.

Preparation

synthesis of 2,4,5-trifluorophenylacetic acid: A 100 mL flask was charged 10.0 g of 2,4,5-trifluoromandelic acid, 23.9 g of H3PO3 (6 eq.), 0.73 g of Nal (0.1 eq.) and 0.47 g (0.10 eq.) of MSA. The obtained mixture was stirred at 95-105°C for 24 hrs. Once the conversion is completed (by HPLC; conversion > 99%, typically achieved after 24 hours), the mixture is cooled to room temperature, and 20 mL of methyl tert-butyl ether were added and then 20 mL of water where added. The obtained mixture was stirred for 5 min, then the organic layers were separated. Then 10 mL of methyl tert-butyl ether was added to the aqueous layers, stirred for 5 min, then the phase were separated. The organic layers were combined. The combined organic layers were concentrated under vacuum at 35°C, to provide crude 2,4,5-trifluorophenylacetic acid(TFPAA). To the obtained crude TFPAA was recrystallized from toluene, to obtain TFPAA, as a white crystals, 6.4 g, molar yield 69.5%, chemical purity of HPLC 99.47% A/A%

2,4,5-Trifluorophenylacetic acid Preparation Products And Raw materials

Raw materials

1,4-Dioxane Copper(I) chloride Sodium tert-butoxide Diethyl malonate 1-Bromo-2,4,5-trifluorobenzene

Preparation Products

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2,4,5-Trifluorophenylacetic acid Suppliers

Australia 1 CHINA 503 Europe 3 France 1 Germany 5 India 21 Italy 1 Japan 1 South Korea 1 Switzerland 1 The Netherlands 1 Ukraine 1 United Kingdom 13 United States 30 Global 583

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View Lastest Price from 2,4,5-Trifluorophenylacetic acid manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: 2,4,5-Trifluorophenylacetic acid 209995-38-0
Price: US $65.00-20.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-06-04

Hebei Mojin Biotechnology Co.,Ltd

Product: 2,4,5-Trifluorophenylacetic acid 209995-38-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2024-08-23

Lewoo Pharmatech(Shanghai)Co.,Ltd

Product: 2,4,5-Trifluorophenylacetic acid 209995-38-0
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99.5%
Supply Ability: 10tons
Release date: 2023-02-11

209995-38-0, 2,4,5-Trifluorophenylacetic acidRelated Search:

Nitrilotriacetic acid 1,3,5-Trifluorobenzene Trimethyl orthoacetate Ethyl trifluoroacetate Glycyl-glycyl-glycine Triphenyltin acetate Trifluoroacetic acid Trifluoroacetic anhydride 2,3,5-TRIFLUOROPHENYLACETIC ACID 2,2-Dimethyl-1,3-dioxane-4,6-dione Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate Sitagliptin Benzenebutanoicacid,b-[[(1,1-diMethylethoxy)carbonyl]aMino]-2,4,5-trifluoro-,Methylester,(bR)- (R)-methyl 3-acetamido-4-(2,4,5-trifluorophenyl)butanoate 2,4,5-TRIFLUOROBENZYL CHLORIDE Sitagliptin Impurity 34 2-CHLOROMETHYL-5-TRIFLUOROMETHYL-[1,3,4]OXADIAZOLE ethyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate

trifluorophenylacetic acid

2-(3,4-difluorophenyl)-2-fluoroacetic acid

2,4,5-Trifluorophenylacetic acid （Sitagliptin）

RARECHEM AL BO 0510

2,4,5-TRIFLUOROPHENYLACETIC ACID

2,4,5-Trifluorophenylaceticacid97%

Two, four, five, three fluorine benzene acetic acid

Benzeneaceticacid,2,4,5-trifluoro-

Trifluorophenylacetic Aci

2,4,5-Trifluorophenylacetic acid ,99%

2,4,5-Trifluoropheny

2,4,5-trifluoropheylacetic acid

5-Trifluorophenylacetic acid

2, 4, 5-Trifluorobenzeneacetic acid

2,4,5-trifiuorophenylacetic acid

2,4,5-triflouorophenyl acetic acid

RETAG-001

2,4,5-Trifluoropheny245

2,4,5-Trifluorophenylacetic acid ISO 9001：2015 REACH

2-(2,4,5-trifluorophenyl)acetic acid(209995-38-0)

2-(2,4,5-trifluorophenyl)aceticaci

2,4,5-trfluorophenylacetic acid

2,4,5-trifluorophenylacetic acid,TFPAA

2,4,5-Trifluorophenylacetic Acid 2,4,5-Trifluorophenylacetic Acid

209995-38-0

20995-38-0

C8H5F3NO2

Acetics acid and esters

Benzene series

Phenylacetic acid

Miscellaneous

C8

Carbonyl Compounds

Carboxylic Acids