Maprotiline hydrochloride

Product Name: Maprotiline hydrochloride
CAS No.: 10347-81-6
Chemical Name: Maprotiline hydrochloride
Synonyms: ba34276;Psymion;Maprolu;Deprilept;ciba34276ba;LUDIOMIL HCL;Ludiomil tab;Einecs 233-758-8;Ludiomil comprimes;ciba34276hydrochloride
CBNumber: CB6297617
Molecular Formula: C20H24ClN
Formula Weight: 313.86
MOL File: 10347-81-6.mol

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Maprotiline hydrochloride Property

Melting point:: 230-232°C
Flash point:: 9℃
storage temp.: 2-8°C
solubility: H₂O: 50 mg/mL
form: powder
color: white
Water Solubility: Soluble to 50mg/ml in water. Soluble in ethanol at 10mM
Merck: 14,5748
InChI: InChI=1/C20H23N.ClH/c1-21-14-6-12-20-13-11-15(16-7-2-4-9-18(16)20)17-8-3-5-10-19(17)20;/h2-5,7-10,15,21H,6,11-14H2,1H3;1H/t15-,20+;
InChIKey: NZDMFGKECODQRY-ZLYMRNBRNA-N
SMILES: [C@@]12(CCCNC)CC[C@@]([H])(C3C=CC=CC1=3)C1C=CC=CC2=1.Cl |&1:0,8,r|

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Safety

Hazard Codes: Xn,T,F
Risk Statements: 22-39/23/24/25-23/24/25-11
Safety Statements: 7-16-36/37-45
RIDADR: 3249
WGK Germany: 3
RTECS: KJ4555000
HazardClass: 6.1(b)
PackingGroup: III
HS Code: 2921490002
Toxicity: LD50 in mice, rats (mg/kg): ~750, ~900 orally (Hess)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR3033
Product name: Maprotiline Hydrochloride
Purity: pharmaceutical secondary standard, certified reference material
Packaging: 500MG
Price: $173
Updated: 2024/03/01

Sigma-Aldrich

Product number: M-920
Product name: Maprotiline hydrochloride solution
Purity: 1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant?
Packaging: 1mL
Price: $49
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1375207
Product name: Maprotiline hydrochloride
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $235.8
Updated: 2024/03/01

TCI Chemical

Product number: M2527
Product name: Maprotiline Hydrochloride
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $76
Updated: 2024/03/01

TCI Chemical

Product number: M2527
Product name: Maprotiline Hydrochloride
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $261
Updated: 2024/03/01

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Maprotiline hydrochloride Chemical Properties,Usage,Production

Description

Maprotiline is a tricyclic antidepressant. It binds to the norepinephrine transporter (NET; K_d = 11 nM) and is selective for NET over the serotonin (5-HT) and dopamine transporters (K_ds = 5,800 and 1,000 nM, respectively). Maprotiline also binds to the 5-HT receptor subtype 5-HT_2A (K_I = 51 nM), as well as histamine H₁, muscarinic acetylcholine, α₁-adrenergic, and dopamine D₂ receptors (K_ds = 2, 570, 90, and 350 nM, respectively). In vivo, maprotiline inhibits norepinephrine reuptake in rat brain and peripheral tissues. It reduces isolation-induced aggressive behavior and inhibits electrical foot-shock stimulation-induced belligerence in mice when administered at doses ranging from 3 to 10 mg/kg. Maprotiline (20 μM) prevents acid sphingomyelinase activation and subsequent ceramide release induced by infection with replication-deficient vesicular stomatitis virus pseudoviral particles (pp-VSV) presenting the severe acute respiratory coronavirus 2 (SARS-CoV-2) spike protein in Vero cells, an effect that can be overcome with exogenous application of C16 ceramide . Formulations containing maprotiline have been used in the treatment of depression and anxiety. This product is also available as an analytical reference material (Item Nos. 32702 | 33077).

Chemical Properties

Crystalline Solid

Originator

Maprotiline hydrochloride ,Mylan

Uses

Antidepressant

Uses

estrogen, with progesterone as oral contraceptive

Uses

Maprotiline Hydrochloride has also been shown to block apoptosis of spiny neurons and inhibit SLC6A2.

Definition

ChEBI: Maprotiline hydrochloride is a member of anthracenes.

Manufacturing Process

9-(3-Hydroxypropyl)anthracene was prepared by reduction of 3-(9-anthryl) propionic acid with LiAlH4. By action of thionylchloride and then methylamine the 9-(3-hydroxypropyl)anthracene was converted to 9-(3-methylaminopropyl) anthracene. By addition of ethylene to 9-(3-methylaminopropyl)anthracene (at 150°C, a pressure of ethylene 50 atm, 24 hours) was obtained 3-(9,10- dihydro-9,10-ethanoanthracene-9-yl)-N-methylpropylamine. Hydrochloride 3- (9,10-dihydro-9,10-ethanoanthracene-9-yl)-N-methylpropylamine may be prepared by action hydrochloric acid.

Therapeutic Function

Antidepressant

General Description

Maprotiline hydrochloride, N-methyl-9,10-ethanoanthracene-9(10H)-propanamine hydrochloride (Ludiomil), is sometimesdescribed as a tetracyclic rather than a tricyclic antidepressant.The description is chemically accurate, but the compound,nonetheless, conforms to the overall TCA pharmacophore. Itis a dibenzobicyclooctadiene and can be viewed as a TCAwith an ethylene-bridged central ring. The compound is notstrongly anticholinergic and has stimulant properties. It canhave effects on the cardiovascular system. It is a SNERI.

Biological Activity

Selective noradrenalin re-uptake inhibitor.

Maprotiline hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Maprotiline hydrochloride Suppliers

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View Lastest Price from Maprotiline hydrochloride manufacturers

shandong perfect biotechnology co.ltd

Product: Maprotiline Hydrochloride 10347-81-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98% HPLC
Supply Ability: 1000kg
Release date: 2023-07-06

Xiamen Wonderful Bio Technology Co., Ltd.

Product: Maprotiline Hydrochloride 10347-81-6
Price: US $30.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 6000
Release date: 2023-06-06

Baoji Guokang Healthchem co.,ltd

Product: Maprotiline hydrochloride 10347-81-6
Price: US $71.40-365.10/g
Min. Order: 1g
Purity: 99%
Supply Ability: 500g
Release date: 2021-06-07

10347-81-6, Maprotiline hydrochlorideRelated Search:

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10-ethanoanthracene-9(10h)-propylamine,n-methyl-hydrochloride

ba34276

ciba34276ba

ciba34276hydrochloride

n-methyl-9,10-ethanoanthracene-9(10h)-propanaminehydrochloride

9-[GAMMA-METHYLAMINOPROPYL]-9,10-DIHYDRO-9,10-ETHANOANTHRACENE HYDROCHLORIDE

1-(3-METHYLAMINOPROPYL)DIBENZO[B,E]BICYCLO[2.2.2]OCTADIENE HYDROCHLORIDE

MAPROTILENE HYDROCHLORIDE

MAPROTILINE HYDROCHLORIDE

LUDIOMIL HCL

Deprilept

N-Methyl-9,10-ethanoanthracene-9(10H)-propylamine Hydrochloride

Psymion

Ludiomil comprimes

Ludiomil tab

9,10-Ethanoanthracene-9(10H)-propanamine, N-methyl-, hydrochloride

9-(γ-methylaminopropyl)-9,10-dihydro-9,10-ethanoanthracene hydrochloride

Maprolu

9,10-Ethanoanthracene-9(10H)-propylamine, N-methyl-, hydrochloride

Einecs 233-758-8

Maprotiline hydrochloride,9-(γ-Methylaminopropyl)-9,10-dihydro-9,10-ethanoanthracene hydrochloride

Maprotiline Hydrochloride (200 mg)

Maprotiline, LudioMil Hydrochloride

N-methyl-9,10-ethanoanthracene-9(10H)-propanamine,hydrochloride (1:1)

Maprotiline hydrochloride solution

Maprotiline hydrochloride CRS

Maprotiline Hydrochloride, 98.0+ % (HPLC)

MaprotilineHydrochloride&gt

Maprotiline hydrochloride USP/EP/BP

Maprotilinhydrochlorid

3-(9,10-Ethanoanthracen-9(10H)-yl)-N-methylpropan-1-amine hydrochloride

Maprotiline hydrochloride 13CD3

Maprotiline Hydrochloride (1375207)

Maprotiline HCl|||Psymion|||Deprilept|||Ludiomil

Maprotiline hydrochloride in methanol

Maprotiline hydrochloride, Noradrenaline reuptake inhibitor

10347-81-6

C20H23NHCl

Selective norepinephrine uptake inhibitor.

Chemical Amines

Amines

Intermediates & Fine Chemicals

Pharmaceuticals

Adrenoceptor

Active Pharmaceutical Ingredients