2,6-DIMETHYLANILINE HYDROCHLORIDE

Product Name: 2,6-DIMETHYLANILINE HYDROCHLORIDE
CAS No.: 21436-98-6
Chemical Name: 2,6-DIMETHYLANILINE HYDROCHLORIDE
Synonyms: Einecs 244-388-1;CompoundAR0033QU;ROPIVACAINE RC A;Compound AR0033QU;Lidocaine Impurity 50;Ropivacaine Impurity A;2,6-DimethylanilineHCl;2,6-xylidinium chloride;Bupivacaine EP Impurity F;2,6-XYLIDINE HYDROCHLORIDE
CBNumber: CB6299479
Molecular Formula: C8H12ClN
Formula Weight: 157.64
MOL File: 21436-98-6.mol

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2,6-DIMETHYLANILINE HYDROCHLORIDE Property

Melting point:: 275°C
storage temp.: Inert atmosphere,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly, Sonicated)
form: powder or crystals
color: White to Pale Brown
Stability:: Hygroscopic

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Safety

Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
RTECS: ZF0375000
HS Code: 2921490002
Toxicity: rat,LD50,oral,2042mg/kg (2042mg/kg),Journal of Pharmacology and Experimental Therapeutics. Vol. 167, Pg. 223, 1969.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 901252
Product name: 2,6-Dimethylaniline hydrochloride
Purity: ≥98%
Packaging: 1G
Price: $44.2
Updated: 2025/07/31

Sigma-Aldrich

Product number: PHR2572
Product name: Ropivacaine Related Compound A
Purity: certified reference material, pharmaceutical secondary standard
Packaging: 50MG
Price: $557
Updated: 2025/07/31

Sigma-Aldrich

Product number: 901252
Product name: 2,6-Dimethylaniline hydrochloride
Purity: ≥98%
Packaging: 5G
Price: $121
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1605512
Product name: Ropivacaine Related Compound A
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 25mg
Price: $1470
Updated: 2025/07/31

TCI Chemical

Product number: X0029
Product name: 2,6-Dimethylaniline Hydrochloride
Purity: >98.0%(HPLC)(N)
Packaging: 25g
Price: $172
Updated: 2025/07/31

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2,6-DIMETHYLANILINE HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

2,6-Dimethylaniline hydrochloride may be used in the preparation of 2,6-dimethylphenyl isocyanate via phosgenation. This product was previously listed as CDS000447.

Synthesis

2198-53-0

925-90-6

21436-98-6

The general procedure for the synthesis of 2,6-dimethylaniline hydrochloride from 2,6-dimethylacetanilide and ethylmagnesium bromide was as follows: trifluoromethanesulfonic anhydride (Tf2O, 185 μL, 1.1 mmol) was added slowly and dropwise to a cooled-to-0°C dichloromethane ( 4 mL) solution. The reaction mixture was stirred at 0 °C for 30 min, then transferred to -78 °C and a solution of tetrahydrofuran (THF, 15 mL) of freshly prepared organocerium reagent/complex (3.0 mmol) was added, and stirring was continued for 2 hours. Upon completion of the reaction, the reaction was quenched by the addition of a 3 mol/L aqueous hydrochloric acid solution (5 mL) and the mixture was gradually warmed to room temperature with continued stirring for 2 hours. Subsequently, 25% ammonium hydroxide solution (5 mL) was added to the mixture. The organic layer was separated and the aqueous phase was extracted with ether (3 x 10 mL). The organic layers were combined, washed with saturated saline (3 x 3 mL) and concentrated under reduced pressure to about 1/3 of the original volume. the residual organic phase was extracted with 3 mol/L aqueous hydrochloric acid solution (3 x 5 mL). The separated organic phase was washed with saturated saline (5 mL), dried with anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure, and the residue was purified by silica gel fast column chromatography to obtain the target ketone product. All aqueous phases were combined, washed with ether (5 mL) and alkalized with 25% ammonium hydroxide solution (5 mL), then back-extracted with ether (5×20 mL). The ether layers were combined, washed with saturated saline (5 mL), dried over anhydrous magnesium sulfate (MgSO4), filtered and acidified with 3 mol/L ethyl acetate hydrochloride solution (5 mL), and finally concentrated under reduced pressure to give 2,6-dimethylaniline hydrochloride.

References

[1] Chinese Chemical Letters, 2015, vol. 26, # 9, p. 1055 - 1058

2,6-DIMETHYLANILINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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2,6-DIMETHYLANILINE HYDROCHLORIDE Suppliers

China 97 France 1 Germany 2 India 8 Japan 1 United Kingdom 4 United States 12 Global 125

J & K SCIENTIFIC LTD.

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View Lastest Price from 2,6-DIMETHYLANILINE HYDROCHLORIDE manufacturers

Moxin Chemicals

Product: Ropivacaine EP Impurity H(Hydrochloride) 21436-98-6
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 99%+ HPLC
Supply Ability: 1000
Release date: 2025-07-02

Apeloa production Co.,Limited

Product: 2,6-Dimethylaniline Hydrochloride 21436-98-6
Price: US $1.00/g
Min. Order: 1g
Purity: 0.98
Supply Ability: 1000
Release date: 2024-07-18

Career Henan Chemical Co

Product: 2,6-DIMETHYLANILINE HYDROCHLORIDE 21436-98-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 10 tons
Release date: 2020-01-10

21436-98-6, 2,6-DIMETHYLANILINE HYDROCHLORIDERelated Search:

2',6'-Pipecoloxylidide Bupivacaine-d9 4-Hydroxy-N-desbutyl Bupivacaine Bupivacaine Impurity 1-Butyl-1-oxido-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide hydrochloride Bupivacaine Impurity Linocaine hydrochloride Alachlor 2-Chloro-N-(2,6-dimethylphenyl)acetamide 5-CHLORO-7-METHYLISATIN 4-Chloro-7-methylisatin 4,4'-Carbonimidoylbis(N,N-dimethylaniline) hydrochloride 2,4-DIMETHYLANILINE HYDROCHLORIDE 98+%,2,4-DIMETHYLANILINE HYDROCHLORIDE N,N-DIMETHYLANILINE HYDROCHLORIDE 4-CHLORO-2,6-DIMETHYLANILINE HYDROCHLORIDE 3,3',5,5'-TETRAMETHYLBENZIDINE DIHYDROCHLORIDE HYDRATE 6-CHLORO-7-METHYL ISATIN AKOS BBS-00003981

2,6-XYLIDINE HYDROCHLORIDE

2,6-DIMETHYLANILINE HYDROCHLORIDE

2,6-xylidinium chloride

2,6-DimethylanilineHCl

Einecs 244-388-1

Ropivacaine Related Compound A (25 mg) (2,6-dimethylaniline hydrochloride)

Ropivacaine Related CoMpound A

Ropivacaine Impurity A

2,6-DIMETHYLANILINE HYDROCHLORIDE 98+%

Bupivacaine EP Impurity F HCl (Ropivacaine EP Impurity H HCl)

Bupivacaine EP Impurity F HCl

Ropivacaine EP Impurity H HCl

Ropivacaine EP Impurity H HCl (Bupivacaine EP Impurity F HCl)

Bupivacaine EP Impurity F

2,-6-Dimethylaniline Hydrochloride Certified Reference Standard

Ropivacaine RC A / Ropivacaine EP Impurity H

Ropivacaine Related Compound A.HCl

Ropivacaine Related Compound A (2,6-dimethylaniline hydrochloride) (1605512)

Ropivacaine Related Compound A as Hydrochloride

Ropivacaine USP Related Compound A as Hydrochloride

Compound AR0033QU

CompoundAR0033QU

Lidocaine Hydrochloride Impurity A as Hydrochloride

Lidocaine EP Impurity A(Bupivacaine EP Impurity F

Lidocaine Hydrochloride EP Impurity A as Hydrochloride

Bupivacaine EP Impurity F(Ropivacaine EP Impurity H HCl)

Lidocaine Impurity 50

ROPIVACAINE RC A

Dapagliflozin Impurity 125

Lidocaine EP Impurity A HCl

Lidocaine EP Impurity A HCl (Bupivacaine EP Impurity F HCl, Ropivacaine EP Impurity H HCl, Ropivacaine USP Related Compound A)

ROPIVACAINE RELATED COMPOUND A (2LOTS)

Ropivacaine EP Impurity H(Hydrochloride)

21436-98-6

C8H11NHCl