ChemicalBook > CAS DataBase List > 6-Maleimidocaproic acid
6-Maleimidocaproic acid
- Product Name
- 6-Maleimidocaproic acid
- CAS No.
- 55750-53-3
- Chemical Name
- 6-Maleimidocaproic acid
- Synonyms
- 6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoic acid;EMCA;6-MALEIMIDOHEXANOIC ACID;6-(2,5-Dioxo-2H-pyrrol-1(5H)-yl)hexanoic acid;MalHex;Maleimide-(CH2)5-COOH;6-MaleimidocaproicAci;Mal-(CH2)5-COOH (EMCA);6-MALEIMIDOCAPROIC ACID;6-MaleiMidocapronic acid
- CBNumber
- CB6300928
- Molecular Formula
- C10H13NO4
- Formula Weight
- 211.21
- MOL File
- 55750-53-3.mol
More
Less
6-Maleimidocaproic acid Property
- Melting point:
- 86-91 °C
- Boiling point:
- 407.3±28.0 °C(Predicted)
- Density
- 1.285±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO (Slightly), Ethyl Acetate (Slightly)
- pka
- 4.74±0.10(Predicted)
- form
- Powder
- color
- White to pale yellow
- Water Solubility
- Soluble in water, methanol, ethanol, dimethyl sulfoxide. Insoluble in ether.
- Sensitive
- Moisture Sensitive
- BRN
- 1532405
- InChIKey
- WOJKKJKETHYEAC-UHFFFAOYSA-N
- CAS DataBase Reference
- 55750-53-3(CAS DataBase Reference)
- EPA Substance Registry System
- 1H-Pyrrole-1-hexanoic acid, 2,5-dihydro-2,5-dioxo- (55750-53-3)
More
Less
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38-41-37/38
- Safety Statements
- 26-36-39
- WGK Germany
- 3
- F
- 10-21
- HS Code
- 29251900
More
Less
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
More
Less
N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 755842
- Product name
- 6-Maleimidohexanoic acid
- Purity
- 90% (GC)
- Packaging
- 25g
- Price
- $224
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- 63176
- Product name
- 6-Maleimidohexanoic acid
- Purity
- ≥98.0% (HPLC)
- Packaging
- 1g
- Price
- $585
- Updated
- 2024/03/01
TCI Chemical
- Product number
- M2338
- Product name
- 6-Maleimidohexanoic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $84
- Updated
- 2024/03/01
TCI Chemical
- Product number
- M2338
- Product name
- 6-Maleimidohexanoic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $336
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- 046384
- Product name
- 6-Maleimidohexanoic acid
- Packaging
- 5g
- Price
- $50
- Updated
- 2024/03/01
More
Less
6-Maleimidocaproic acid Chemical Properties,Usage,Production
Description
6-Maleimidocaproic acid contains a maleimide group and a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.
Chemical Properties
White to yellow solid, powder, crystals or crystaline powder.
Uses
6-Maleimidohexanoic acid is used as a probe for introducing maleimides groups into biomolecules and active pharmaceutical ingredients. Further, it is used with N-hydroxysuccinimide ester as a bifunctional cross-linking reagent. In addition to this, it acts as a probe for thiol groups in membrane proteins.
Definition
ChEBI: 6-Maleimidocaproic acid is a medium-chain fatty acid. It contains a maleimide group and a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.
Application
6-Maleimidocaproic acid is a sulfhydryl reactive heterobifunctional crosslinking reagent. It can be widely used probe for introducing maleimides groups into biomolecules. A probe for thiol groups in proteins. Spacer Arm: 9.4 Angstroms. Probe for thiol groups (SH-groups) in membrane proteins.
Synthesis
Maleic anhydride (29.4 g, 0.3 mol) and 6-aminocaproic acid (39.35 g, 0.3 mol) were refluxed in
glacial acetic acid (900 mL) for 16 h. Acetic anhydride (30.6 g, 0.3 mol) was added dropwise over
a period of 2 hand reflux was continued for 1 h. The acetic acid was removed under vacuum at 70
°C to yield yellow syrup which solidified. The material was chromatographed over silica using
dichloromethane-methanol-acetic acid (100:5:1) affording a crystalline solid (6-Maleimidocaproic acid).
6-Maleimidocaproic acid Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
6-Maleimidocaproic acid Suppliers
- Tel
- 0512-68311833 13962195826
- Fax
- 0512-68417696
- wuhao@highfine.com
- Country
- China
- ProdList
- 498
- Advantage
- 75
- Tel
- +8613162137806 18575662672
- Fax
- 021 51613951
- mzeng@3wpharm.com
- Country
- China
- ProdList
- 9743
- Advantage
- 57
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 821-50328103-801 18930552037
- Fax
- 86-21-50328109
- 3bsc@sina.com
- Country
- China
- ProdList
- 15848
- Advantage
- 69
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30132
- Advantage
- 84
- Tel
- 021-67121386
- Fax
- 021-67121385
- Sales-CN@TCIchemicals.com
- Country
- China
- ProdList
- 24539
- Advantage
- 81
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44700
- Advantage
- 61
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- sales@capotchem.com
- Country
- China
- ProdList
- 18217
- Advantage
- 66
- Tel
- 010-82967028 13552068683
- Fax
- +86-10-82967029
- 2355560935@qq.com
- Country
- China
- ProdList
- 12458
- Advantage
- 60
- Tel
- 13817811078
- Fax
- 86-021-50426522,50426273
- sales@jingyan-chemical.com
- Country
- China
- ProdList
- 9984
- Advantage
- 60
- Tel
- 0573-85285100 18627885956
- Fax
- 0573-85285100
- isenchem@163.com
- Country
- China
- ProdList
- 9549
- Advantage
- 66
- Tel
- 025-85760892 13376090521
- Fax
- 025-85766769
- sales@habotech.com
- Country
- China
- ProdList
- 995
- Advantage
- 60
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- sales@accelachem.com
- Country
- China
- ProdList
- 11660
- Advantage
- 64
- Tel
- 025-83697070
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 18088
- Advantage
- 64
- Tel
- 021-021-64543801 13764082696
- 2355241799@qq.com
- Country
- China
- ProdList
- 42982
- Advantage
- 64
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32344
- Advantage
- 50
- Tel
- +86 (531) 88811783
- Fax
- +86 (531) 55696010 QQ 1762738062
- sales@trio-pharmatech.com (International market)
- Country
- China
- ProdList
- 1856
- Advantage
- 62
- Tel
- 400 638 7771
- sales@heowns.com
- Country
- China
- ProdList
- 14443
- Advantage
- 57
- Tel
- 028-82550498 19102685862
- Fax
- 086-28-82550468
- sales@pu-kang.com
- Country
- China
- ProdList
- 485
- Advantage
- 58
- Tel
- 021-021-021-67601398-809-809-809 15221380277
- Fax
- 021-57711696
- marketing_china@spectrumchemical.com
- Country
- China
- ProdList
- 9664
- Advantage
- 60
- Tel
- 021-61312847 13636370518
- Fax
- 021-55068248
- shyysw007@163.com
- Country
- China
- ProdList
- 4941
- Advantage
- 60
- Tel
- 028-85114309 15881143215
- liangli@happysyn.com
- Country
- China
- ProdList
- 1734
- Advantage
- 55
- Tel
- 021-61551611 13296011611
- Fax
- ＋86 21-50676805
- contact@trustwe.com
- Country
- China
- ProdList
- 9900
- Advantage
- 58
- Tel
- +86 21 61551611
- Fax
- +86 21 50676805
- Country
- China
- ProdList
- 9901
- Advantage
- 58
- Tel
- 025-66099280 17798518460
- Fax
- (1)02557626880
- cfzhang@aikonchem.com
- Country
- China
- ProdList
- 19918
- Advantage
- 55
- Tel
- 0752-5538396 18927339850
- Fax
- 0752-5319394
- sales1@rafflespt.com
- Country
- China
- ProdList
- 218
- Advantage
- 58
- Tel
- 18017383231 18017383231
- Fax
- qq：2817624287
- lyh_antaeus@163.com
- Country
- China
- ProdList
- 9352
- Advantage
- 55
- Tel
- 18521735133 18521732826;
- Fax
- 021-50323701
- market@aladdin-e.com
- Country
- China
- ProdList
- 25014
- Advantage
- 65
- Tel
- 021-61552785
- Fax
- 021-55660885
- sales@shshiji.com
- Country
- China
- ProdList
- 9552
- Advantage
- 55
- Tel
- +86-021-50935922
- Fax
- +86-021-33847795
- Country
- China
- ProdList
- 7876
- Advantage
- 55
- Tel
- 021-021-33632979 15002134094
- Fax
- 021-33632979
- marketing@targetmol.com
- Country
- China
- ProdList
- 7854
- Advantage
- 58
- Tel
- 400-1647117 15221909166
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 41438
- Advantage
- 60
- Tel
- 028-65294243
- Fax
- 028-85275169
- sales@ampebiochem.com
- Country
- China
- ProdList
- 1017
- Advantage
- 58
- Tel
- 400-8592883 15367835770
- Fax
- 0731-82251112
- viola@huatengsci.com
- Country
- China
- ProdList
- 5877
- Advantage
- 58
- Tel
- 021-24206007 13764915196
- Fax
- 86-021-23027023
- sales@balmxy.com
- Country
- China
- ProdList
- 6737
- Advantage
- 55
- Tel
- 400-026-1533/(021) 6478-0600
- Fax
- +86 (21) 6459-2060
- sales@bokachem.com
- Country
- China
- ProdList
- 876
- Advantage
- 58
- Tel
- 15221275939 15221275939
- Fax
- 021-50706099
- shenlinxing@macklin.cn
- Country
- China
- ProdList
- 15885
- Advantage
- 55
- Tel
- 021-69106960 13701823733
- Fax
- 021-69106780
- 13701823733@163.com
- Country
- China
- ProdList
- 4775
- Advantage
- 60
- Tel
- 021-61478794
- Fax
- 021-61478794
- sales@hcshhai.com
- Country
- China
- ProdList
- 9798
- Advantage
- 50
- Tel
- 010-56218822 13717722232
- Fax
- 010-56218800
- xinsavichem@163.com
- Country
- China
- ProdList
- 3201
- Advantage
- 56
- Tel
- 13718199399
- Fax
- QQ : 206661479
- holiyangchem@163.com
- Country
- China
- ProdList
- 3387
- Advantage
- 56
- Tel
- 021-69005955 13701776567
- Fax
- 021-69005775
- youpengchem@163.com
- Country
- China
- ProdList
- 4303
- Advantage
- 56
- Tel
- 13708085536
- Fax
- QQ : 121102042
- hanovichem@163.com
- Country
- China
- ProdList
- 3389
- Advantage
- 56
- Tel
- 025-58849295 18951903616;
- Fax
- 025-68650336
- info@adooq.cn
- Country
- China
- ProdList
- 2989
- Advantage
- 60
- Tel
- 021-021-69182866 13701855675
- Fax
- 021-69182022
- tongyuanchem@126.com
- Country
- China
- ProdList
- 4331
- Advantage
- 58
- Tel
- 021-33516722 13701817765
- Fax
- 021-33516776
- kaisaichem@163.com
- Country
- China
- ProdList
- 4751
- Advantage
- 58
- Tel
- 13716033033
- Fax
- 010-56276266
- hanchochem@163.com
- Country
- China
- ProdList
- 2960
- Advantage
- 50
- Tel
- 021-69515658 ; 69515628 13701998368
- Fax
- 021-69515998
- longrunchem@163.com
- Country
- China
- ProdList
- 3920
- Advantage
- 50
- Tel
- 021-69992220 13701886816
- Fax
- 021-69992237
- roleadchem@163.com
- Country
- China
- ProdList
- 4759
- Advantage
- 50
- Tel
- 021-69185552 13701777608
- Fax
- 021-69186006
- kangtuochem@163.com
- Country
- China
- ProdList
- 4370
- Advantage
- 55
More
Less
View Lastest Price from 6-Maleimidocaproic acid manufacturers
Jinan Finer Chemical Co., Ltd
- Product
- 6-Maleimidocaproic acid 55750-53-3
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20mt
- Release date
- 2019-03-28
Hebei Guanlang Biotechnology Co., Ltd.
- Product
- 6-Maleimidocaproic acid 55750-53-3
- Price
- US $10.00/PCS
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100 mt
- Release date
- 2021-04-26
WUHAN FORTUNA CHEMICAL CO., LTD
- Product
- 6-Maleimidocaproic acid 55750-53-3
- Price
- US $0.00/Kg/Bag
- Min. Order
- 10g
- Purity
- 98%min HPLC
- Supply Ability
- 100KGS
- Release date
- 2021-08-06
55750-53-3, 6-Maleimidocaproic acidRelated Search:
Citric acid
N,N'-1,3-Phenylene bismaleimide
Folic acid
N-Benzylmaleimide
Bismaleimide
Ethyl 2-(Chlorosulfonyl)acetate
Hyaluronic acid
O-Phthalimide
N-Phenylmaleimide
Hexanoic acid
N-Ethylmaleimide
Maleimide
Succinimide
Ascoric Acid
Polyamideimide
SMCC crosslinker
N-Succinimidyl 6-maleimidohexanoate
DIALIFOS