ChemicalBook > CAS DataBase List > Raloxifene hydrochloride

Raloxifene hydrochloride

Product Name
Raloxifene hydrochloride
CAS No.
82640-04-8
Chemical Name
Raloxifene hydrochloride
Synonyms
CS-127;ly156758;KEOXIFENE;LY 139481;AKOS 92138;RALOXFENE HCL;RALOXIFENE HCL;LY156758 hydrochloride;LY139481 hydrochloride;Latilavir secondary VI
CBNumber
CB6302366
Molecular Formula
C28H28ClNO4S
Formula Weight
510.04
MOL File
82640-04-8.mol
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Raloxifene hydrochloride Property

Melting point:
250-253°C
storage temp. 
2-8°C
solubility 
DMSO: 28 mg/mL, soluble
form 
solid
color 
light yellow
λmax
286nm(lit.)
Merck 
14,8098
BCS Class
2
InChI
InChI=1S/C28H27NO4S.ClH/c30-21-8-4-20(5-9-21)28-26(24-13-10-22(31)18-25(24)34-28)27(32)19-6-11-23(12-7-19)33-17-16-29-14-2-1-3-15-29;/h4-13,18,30-31H,1-3,14-17H2;1H
InChIKey
BKXVVCILCIUCLG-UHFFFAOYSA-N
SMILES
C1(C(=O)C2C=CC(OCCN3CCCCC3)=CC=2)C2C=CC(O)=CC=2SC=1C1C=CC(O)=CC=1.Cl
CAS DataBase Reference
82640-04-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
22-24/25
WGK Germany 
3
RTECS 
PC4956925
HS Code 
2934990002
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H351Suspected of causing cancer

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR1852
Product name
Raloxifene hydrochloride for peak identification
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
500mg
Price
$173
Updated
2024/03/01
Sigma-Aldrich
Product number
1598201
Product name
Raloxifene hydrochloride
Packaging
200mg
Price
$436
Updated
2024/03/01
Cayman Chemical
Product number
27189
Product name
Raloxifene (hydrochloride)
Purity
≥98%
Packaging
50mg
Price
$648
Updated
2024/03/01
Cayman Chemical
Product number
10011620
Product name
Raloxifene (hydrochloride)
Purity
≥98%
Packaging
50mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
10011620
Product name
Raloxifene (hydrochloride)
Purity
≥98%
Packaging
100mg
Price
$61
Updated
2024/03/01
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Raloxifene hydrochloride Chemical Properties,Usage,Production

Description

Raloxifene was launched as Evista in the US for the prevention of postmenopausal osteoporosis. It is noteworthy that this molecule was formerly under development as keoxifene for breast cancer and prostatic hypertrophy. Raloxifene can be prepared by acylation of 6-methoxy-2-(4-methoxyphenyl) benzothiophene followed by simultaneous demethylation of both methoxy groups. Raloxifen is a selective estrogen receptor modulator, exerting antiestrogenic action on certain tissues (breast) and also estrogenic action on bone metabolism or serum lipids. In normal early postmenopausal women, 200 mg daily produced a trend towards suppression of estrogen effects. Raloxifen impeded bone loss in osteoporosis. A two-year study in postmenopausal women with an increased risk for osteoporosis showed that Raloxifen markedly prevented non-traumatic vertebral fractures. Results of several clinical studies demonstrated that Raloxifen appreciably reduced the risk of developing breast cancer. Moreover, it had favourable effect on lipid profiles without having the potential side-effects of estrogen-based therapies. Several extensions for different uses of this molecule are planned, for example growth disorder, obesity, colon tumor and skin atrophy. No serious drug-related events have been reported in the limited number of clinical trials.

Chemical Properties

Light-Yellow Solid

Originator

Lilly (US)

Uses

Raloxifene hydrochloride can be used as a nonsteroidal, selective estrogen receptor modulator (SERM). Antiosteoporotic.

Uses

amino acid, nutrient. A nonsteroidal, selective estrogen receptor modulator (SERM). Antiosteoporotic.Insoluble in water.

Uses

Labeled Raloxifene, intended for use as an internal standard for the quantification of Raloxifene by GC- or LC-mass spectrometry.

Definition

ChEBI: A hydrochloride salt resulting from the reaction of equimolar amounts of raloxifene and hydrogen chloride.

brand name

Evista (Lilly).

General Description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Biochem/physiol Actions

Raloxifene is a selective estrogen receptor modulator (SERM); acts as an anti-estrogen in both breast and uterine tissue while being estrogenic in bone. May have efficacy against estrogen-sensitive cancers.

Clinical Use

Treatment and prevention of osteoporosis in post menopausal women

Drug interactions

Potentially hazardous interactions with other drugs
Anticoagulants: antagonism of anticoagulant effect of coumarins.
Colestyramine: reduced absorption of raloxifene - avoid.

Metabolism

Raloxifene undergoes extensive first pass metabolism to the glucuronide conjugates: raloxifene-4'- glucuronide, raloxifene-6-glucuronide, and raloxifene-6, 4′-diglucuronide.
Raloxifene undergoes enterohepatic recycling, and is excreted almost entirely in the faeces. Less than 6% of dose is excreted in the urine.

storage

+4°C (desiccate)

References

[1] obach rs.potent inhibition of human liver aldehyde oxidase by raloxifene.

Raloxifene hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Raloxifene hydrochloride manufacturers

Wuhan Circle Star Chem-medical Technology Co.,Ltd
Product
Raloxifene hydrochloride 82640-04-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98
Supply Ability
1000
Release date
2025-01-13
Hebei Mojin Biotechnology Co.,Ltd
Product
Raloxifene hydrochloride 82640-04-8
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
50000KG/month
Release date
2024-09-26
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Raloxifene hydrochloride 82640-04-8
Price
US $0.00/Kg/Bag
Min. Order
100g
Purity
97.5%-102;USP
Supply Ability
100KGS
Release date
2021-06-16

82640-04-8, Raloxifene hydrochlorideRelated Search:

Diethoxymethyl acetate 2-Ethoxyphenol Benzo[b]thien-2-ylboronic acid Ethoxyquin Topotecan hydrochloride Phenetidine 1-AdaMantanethylaMine DIETHOXYMETHANE acetic acid, triethoxy-, ethyl ester CHLOROPHOSPHONAZO III Raloxifene 4-Ethoxyphenol Droloxifene Ranitidine hydrochloride Lercanidipine hydrochloride Clindamycin hydrochloride Tramadol hydrochloride Sibutramine hydrochloride

  • RALOXIFENE HCL
  • Raloxifene hydrochloride,Keoxifene hydrochloride, LY 156758, [6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone hydrochloride
  • Raloxifene Hydrochloride (200 mg)
  • 2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethoxy]phenyl}carbonyl)-1-benzothiophen-6-ol hydrochloride
  • (6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)(4-(2-(piperidin-1-yl)ethoxy)phenyl)Methanone hydrochloride
  • Evista(Raloxifene Hydrochloride
  • (6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)-(4-(2-(piperidin-1-yl)ethoxy)phenyl)methanon
  • [6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]-methanone,hydrochloride (1:1)
  • LY156758 (Keoxifene) HCl
  • Evista (Raloxifene HCl)
  • Methanone,[6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]-,hydrochloride (1:1)
  • (6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)-(4-(2-(piperidin-1-yl)ethoxy)phenyl)metha
  • 6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl) ethoxy]phenyl]methanone HCl
  • Raloxifene Hydrochloride Tablets
  • LY156758 hydrochloride
  • CS-127
  • RALOXIFENE HYDROCHLORIDE
  • KEOXIFENE
  • KEOXIFENE HYDROCHLORIDE
  • LY 139481
  • AKOS 92138
  • ly156758
  • methanone,(6-hydroxy-2-(4-hydroxyphenyl)benzo(b)thien-3-yl)(4-(2-(1-piperidin
  • [6-HYDROXY-2-(4-HYDROXYPHENYL)BENZO[B]THIEN-3-YL][4-[2-(1-PIPERIDINYL)ETHOXY]PHENYL]-METHANONE HYDROCHLORIDE
  • [6-Hydroxy-2-(4-Hydroxyphenyl) benzo[b]thien-3-yl]
  • RALOXIFENEHYDROCHLORIDE(SUBJECTTOPATENTFREE)
  • Keoxifene hydrochloride, LY 156758, [6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone hydrochloride
  • LY139481 hydrochloride
  • Raloxifene hydrochloride,>98%
  • [6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone Hydrochloride
  • Raloxifene hydrochloride USP/EP/BP
  • Latilavir secondary VI
  • Raloxifene hydrochloride Evista
  • [6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methanone
  • Raloxefene hydrochloride
  • Raloxifene HCl (LY-139481)
  • Raloxifene hydrochloride (Y0001134)
  • Raloxifene Hydrochloride (1598201)
  • (1aΞ,7aΞ)-1a-methyl-7a-[(2E,7RS,11RS)-3,7,11,15-tetramethylhexadec-2-en-1-yl]-1a,7a-dihydronaphtho[2,3-b]oxirene-2,7-dione (trans-epoxyphytomenadione isomers)
  • RALOXFENE HCL
  • Raloxifene Hydrochlorid
  • Raloxifene hydrochloride, 10 mM in DMSO
  • 82640-04-8
  • 28640-04-8
  • C28H27NO4S.HCl
  • C28H27NO4SClH
  • C28H27NO4SHClC28H28ClNO4S
  • API
  • Pharmaceutical intermediate
  • Inhibitors
  • antifungal
  • Aromatics
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Sulfur & Selenium Compounds
  • Active Pharmaceutical Ingredients
  • Raloxifene
  • Intracellular receptor