DIPHENOXYLATE HYDROCHLORIDE

Product Name: DIPHENOXYLATE HYDROCHLORIDE
CAS No.: 3810-80-8
Chemical Name: DIPHENOXYLATE HYDROCHLORIDE
Synonyms: DIPHENOXYLATE HCL;r1132;DIPHENOXYLATE HYDROCHLORIDE;Diphenoxylate hydrochloride solution;Diphenoxylate for system suitability;Diphenoxylate Hydrochloride CII (200 mg);Diphenoxylate HCL (Subj To Narcotic Permit);DIPHENOXYLATE HYDROCHLORIDE METHANOL SOL UTION;DIPHENOXYLATE HYDROCHLORIDE ANTIPERISTAL TIC, ANTI;Diphenoxylate Hydrochloride (1.0 mg/ml in Methanol)
CBNumber: CB6305387
Molecular Formula: C30H33ClN2O2
Formula Weight: 489.05
MOL File: 3810-80-8.mol

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DIPHENOXYLATE HYDROCHLORIDE Property

Melting point:: 220.5-222°
storage temp.: -20°C
solubility: Very slightly soluble in water, freely soluble in methylene chloride, sparingly soluble in ethanol (96 per cent).
form: Solid
color: White to Off-White

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Safety

RIDADR: 1544
HazardClass: 6.1(b)
PackingGroup: III
HS Code: 2933330000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H317May cause an allergic skin reaction

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P262Do not get in eyes, on skin, or on clothing.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 1219008
Product name: Diphenoxylate for system suitability
Packaging: 200mg
Price: $581
Updated: 2024/03/01

American Custom Chemicals Corporation

Product number: CHM0152896
Product name: DIPHENOXYLATE HYDROCHLORIDE
Purity: 95.00%
Packaging: 5MG
Price: $774.4
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0152896
Product name: DIPHENOXYLATE HYDROCHLORIDE
Purity: 95.00%
Packaging: 50MG
Price: $1871.1
Updated: 2021/12/16

Chemtos

Product number: D-2506
Product name: DiphenoxylateHCl
Packaging: 10mg
Price: $1200
Updated: 2021/12/16

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DIPHENOXYLATE HYDROCHLORIDE Chemical Properties,Usage,Production

Chemical Properties

White or almost white, crystalline powder.

Originator

Lomotil,Searle,US,1960

Uses

Antiperistaltic; antidiarrheal. Controlled substance (opiate).

Definition

ChEBI: The hydrochloride salt of diphenoxylate.

Manufacturing Process

A mixture of 23 parts of the ethyl ester of 4-phenylisonipecotic acid and 15 parts of 2,2-diphenyl-4-
omobutyronitrile in 19 parts of xylene is heated for 24 hours at 100-120°C and then cooled and filtered to remove the precipitate of the hydro
omide of the ethyl ester of 4-phenylisonipecotic acid. The filtrate is then extracted with dilute hydrochloric acid and the extract is rendered alkaline by addition of concentrated aqueous potassium hydroxide and extracted with ether. This ether extract is treated with gaseous hydrogen chloride. The resulting precipitate is collected on a filter. The hydrochloride of the ethyl ester of 2,2-diphenyl-4-(4'-carboxy-4'-phenyl-1'- piperidino)butyronitrile thus obtained melts at about 220.5-222°C. See meperidine hydrochloride for synthesis of 4-phenyl-isonipecotic acid ethyl ester.

Therapeutic Function

Antidiarrheal

Veterinary Drugs and Treatments

Diphenoxylate is an opiate in combination with atropine in antidiarrheal products used primarily in dogs; it also has antitussive properties. Use in cats is controversial and many clinicians do not recommend its use in this species.

DIPHENOXYLATE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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DIPHENOXYLATE HYDROCHLORIDE Suppliers

Canada 1 China 14 Europe 2 India 3 South Korea 1 Switzerland 1 United Kingdom 4 United States 8 Global 34

JOHNSON MATTHEY PHARMA SERVICES

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Whyte Chemicals

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CARBONE SCIENTIFIC CO.,LTD

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View Lastest Price from DIPHENOXYLATE HYDROCHLORIDE manufacturers

Career Henan Chemical Co

Product: :DIPHENOXYLATE HYDROCHLORIDE 3810-80-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 97%-99.9%
Supply Ability: 100kg
Release date: 2019-12-20

3810-80-8, DIPHENOXYLATE HYDROCHLORIDERelated Search:

cyanoformamide Ethyl 1-methyl-4-piperidinecarboxylate Methyl N-methyl piperidine-4-carboxylate Isonipecotic acid hydrochloride Ethyl 4-Methylpiperidine-4-carboxylate Hydrochloride Trimethylacetonitrile 2,2-Diphenylpropionitrile Ethyl 2,2-dimethylphenylacetate DIPHENOXYLATE HYDROCHLORIDE 4-(METHOXYMETHYL)PIPERIDINE Methyl 2,2-dimethylphenylacetate ethyl 2-phenylbutyrate 2-Phenyl-2-ethylbutyric acid Diphenylacetonitrile 4-Methylisonipecotic acid ethyl ester Ethyl 4-piperidinecarboxylate ETHYL 4-AMINOBUTYRATE HYDROCHLORIDE 4-(METHOXYMETHYL)PIPERIDINE HCL

Diphenoxylate for system suitability

Diphenoxylate hydrochloride solution

1-(3-cyano-3,3-diphenylpropyl)-4-phenylisonipecoticacidethylesterhydrochl

ethyl1-(3-cyano-3,3-diphenylpropyl)-4-phenylisonipecotatemonohydrochloride

isonipecoticacid,1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-,ethylester,hydro

r1132

Diphenoxylate HCL (Subj To Narcotic Permit)

DIPHENOXYLATE HCL

DIPHENOXYLATE HYDROCHLORIDE

4-Piperidinecarboxylic acid, 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-, ethyl ester, monohydrochloride

Diphenoxylate Hydrochloride CII (200 mg)

Diphenoxylate Hydrochloride CII (200 mg)I1D3390.998mg/mg(dr)

DIPHENOXYLATE HYDROCHLORIDE METHANOL SOL UTION

DIPHENOXYLATE HYDROCHLORIDE ANTIPERISTAL TIC, ANTI

Diphenoxylate Hydrochloride (1.0 mg/ml in Methanol)

Diphenoxylate HydrochlorideQ: What is Diphenoxylate Hydrochloride Q: What is the CAS Number of Diphenoxylate Hydrochloride Q: What is the storage condition of Diphenoxylate Hydrochloride

3810-80-8

C30H32N2O2HCl

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Aromatics

Heterocycles

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Pharmaceuticals