Amino-PEG36-acid

Appearance Storage Condition

Product Name: Amino-PEG36-acid
CAS No.: 2241751-76-6
Chemical Name: Amino-PEG36-acid
Synonyms: AMINE-PEG24-COOH;Amino-PEG36-acid;amino-dPEG 12-acid;H2N-PEG36-CH2CH2COOH;NH2-PEG24-CH2CH2COOH;NH2-PEG36-CH2CH2COOH;NH2-PEG(24)-COOH 100MG;Amino-PEG36-CH2CH2COOH;Amino-PEG36-propionic acid;Amino-PEG36-acid (HCl salt)
CBNumber: CB63062317
Molecular Formula: C75H151NO38
Formula Weight: 1675
MOL File: 2241751-76-6.mol

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Amino-PEG36-acid Property

Boiling point:: 1181.6±65.0 °C(Predicted)
Density: 1.121±0.06 g/cm3(Predicted)
storage temp.: -20°C
form: solid or viscous liquid
pka: 4.28±0.10(Predicted)
InChIKey: QKMSNDXWGWBERW-UHFFFAOYSA-N
SMILES: C(COCCOCCOCCC(=O)O)OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN

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Safety

HS Code: 2918999090

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Apolloscientific

Product number: BIPG1043
Product name: Amino-PEG36-acid
Packaging: 100mg
Price: $759
Updated: 2021/12/16

purepeg

Product number: 432236
Product name: H2N-PEG36-CH2CH2COOH
Purity: min.97%
Packaging: 1g
Price: $1000
Updated: 2021/12/16

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Amino-PEG36-acid Chemical Properties,Usage,Production

Appearance

Amino-PEG24-acid is in solid powder form.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Description

Amino-PEG24-acid is a PEG derivative containing an amino group with a terminal carboxylic acid. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond.

Uses

Amino-PEG36-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

General Description

Amino-dPEG^?₁₂-acid is a novel amino acid that can be manipulated, modified, and used like most other amino acids. The single molecular weight dPEG^? spacer arms between the terminal amine and the terminal carboxylic acid are of exact length (46.5 ?), allowing for precise spatial control, and they are hydrophilic and non-immunogenic, imparting greater water solubility and hydrodynamic volume to target molecules.

reaction suitability

reagent type: cross-linking reagent
reactivity: carboxyl reactive

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Amino-PEG36-acid Preparation Products And Raw materials

Raw materials

Preparation Products

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Amino-PEG36-acid Suppliers

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2241751-76-6

756526-07-4

C75H151NO38

peg