ChemicalBook > CAS DataBase List > 7-Nitroindazole

7-Nitroindazole

Product Name
7-Nitroindazole
CAS No.
2942-42-9
Chemical Name
7-Nitroindazole
Synonyms
7-NITRO-1H-INDAZOLE;7-NI;NITROINDAZOLE;7-NITROINDAZOLE;INDAZOLE, 7-NITRO-;7-nitro-1h-indazol;7-Nitroindazole>7-NITROINDAZOLE 97+%;1H-Indazole, 7-nitro-;7-Nitro-1H-indazole,98%
CBNumber
CB6306238
Molecular Formula
C7H5N3O2
Formula Weight
163.13
MOL File
2942-42-9.mol
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7-Nitroindazole Property

Melting point:
185-186°C
Boiling point:
290.19°C (rough estimate)
Density 
1.4141 (rough estimate)
refractive index 
1.5500 (estimate)
storage temp. 
-20°C
solubility 
Soluble to 100 mM in DMSO and to 20 mM in ethanol
pka
10.03±0.40(Predicted)
form 
powder to crystal
color 
Light yellow to Brown
Water Solubility 
slightly soluble
BRN 
6809
InChI
InChI=1S/C7H5N3O2/c11-10(12)6-3-1-2-5-4-8-9-7(5)6/h1-4H,(H,8,9)
InChIKey
PQCAUHUKTBHUSA-UHFFFAOYSA-N
SMILES
N1C2=C(C=CC=C2[N+]([O-])=O)C=N1
CAS DataBase Reference
2942-42-9(CAS DataBase Reference)
NIST Chemistry Reference
7-Nitroindazole(2942-42-9)
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Safety

Hazard Codes 
T
Risk Statements 
60-40
Safety Statements 
53-22-36/37/39-45
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
NK7962200
HazardClass 
IRRITANT
PackingGroup 
Ⅲ
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H319Causes serious eye irritation

H351Suspected of causing cancer

H360May damage fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
N7778
Product name
7-Nitroindazole
Purity
≥98%
Packaging
1g
Price
$324
Updated
2024/03/01
Sigma-Aldrich
Product number
N7778
Product name
7-Nitroindazole
Purity
≥98%
Packaging
5g
Price
$1050
Updated
2024/03/01
TCI Chemical
Product number
N0827
Product name
7-Nitroindazole
Purity
>97.0%(GC)
Packaging
1g
Price
$61
Updated
2024/03/01
TCI Chemical
Product number
N0827
Product name
7-Nitroindazole
Purity
>97.0%(GC)
Packaging
5g
Price
$252
Updated
2024/03/01
Alfa Aesar
Product number
L07970
Product name
7-Nitro-1H-indazole, 98%
Packaging
1g
Price
$77.3
Updated
2023/06/20
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7-Nitroindazole Chemical Properties,Usage,Production

Description

7-Nitroindazole is a non-selective inhibitor of NOS isoforms in vitro. However, it shows good anti-nociceptive effects in vivo without affecting blood pressure via inhibition of eNOS. The IC50 values for inhibition of rat nNOS, bovine eNOS, and rat iNOS are 0.71, 0.78, and 5.8 μM, respectively.

Chemical Properties

yellow powder or Yellow orange solid soluble in DMSO.

Uses

7-nitroindazole is a specific inhibitor of neural nitric oxide synthase (nNOS), an enzyme that converts arginine to citrulline and nitric oxide (NO) in neuronal tissue. NO is a key player in the hippocampal long-term potentiation (LTP) and in general cell signaling.

Definition

7-Nitroindazole is a heterocyclic small molecule containing an indazole ring that has been nitrated at the 7 position. It is a potent, selective brain inhibitor of mouse cerebellar Nitric Oxide Synthase, a hemoprotein enzyme that, in neuronal tissue, converts arginine to citrulline and nitric oxide (NO).

Biological Activity

Sodium salt of the non-selective NOS inhibitor 7-nitroindazole (7-Nitroindazole).

7-Nitroindazole Preparation Products And Raw materials

Raw materials

Sodium nitrite Acetic acid 2-Methyl-6-nitroaniline

Preparation Products

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View Lastest Price from 7-Nitroindazole manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
7-Nitroindazole 2942-42-9
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27
Career Henan Chemical Co
Product
7-Nitroindazole 2942-42-9
Price
US $6.68/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
1kg-1000kg
Release date
2020-01-09

2942-42-9, 7-NitroindazoleRelated Search:

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  • Enzyme Inhibitors
  • Enzyme Inhibitors by Enzyme
  • Enzymes, Inhibitors, and Substrates
  • L to O
  • Nitric Oxide Synthase
  • Biochemicals and Reagents
  • BioChemical
  • Inhibitors
  • Nitric Oxide Reagents
  • Nitric Oxide
  • All Inhibitors
  • Indazoles
  • Heterocyclic Compounds
  • Signalling
  • Indoles and derivatives