Bis-PEG6-NHS ester
- Product Name
- Bis-PEG6-NHS ester
- CAS No.
- 1526718-98-8
- Chemical Name
- Bis-PEG6-NHS ester
- Synonyms
- BIS-PEG6-NHS;Di-NHS Ester-PEG6;Bis(2,5-dioxopyrrolidin-1-yl) 4,7,10,13,16,19-hexaoxadocosanedioate;4,7,10,13,16,19-Hexaoxadocosanedioic acid, 1,22-bis(2,5-dioxo-1-pyrrolidinyl) ester
- CBNumber
- CB63062418
- Molecular Formula
- C24H36N2O14
- Formula Weight
- 576.55
- MOL File
- 1526718-98-8.mol
Bis-PEG6-NHS ester Property
- solubility
- Soluble in DMSO, DCM
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- CS-0107647
- Product name
- Bis-PEG6-NHSester
- Purity
- ≥97.0%
- Packaging
- 100mg
- Price
- $230
- Updated
- 2021/12/16
- Product number
- BP-21681
- Product name
- Bis-PEG6-NHSester
- Purity
- 98%
- Packaging
- 100mg
- Price
- $250
- Updated
- 2021/12/16
- Product number
- BP-21681
- Product name
- Bis-PEG6-NHSester
- Purity
- 98%
- Packaging
- 500mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- CS-0107647
- Product name
- Bis-PEG6-NHSester
- Purity
- ≥97.0%
- Packaging
- 250mg
- Price
- $400
- Updated
- 2021/12/16
- Product number
- BP-21681
- Product name
- Bis-PEG6-NHSester
- Purity
- 98%
- Packaging
- 1g
- Price
- $460
- Updated
- 2021/12/16
Bis-PEG6-NHS ester Chemical Properties,Usage,Production
Description
Bis-PEG6-NHS ester is a PEG linker containing two NHS ester groups. The hydrophilic PEG spacer increases solubility in aqueous media. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.
Biological Activity
Bis-PEG6-NHS ester is a PROTAC bridge and belongs to the PEG class. It can be used to synthesize a range of PROTAC molecules. Also Bis-PEG6-NHS ester is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).
in vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
target
| Cleavable
| PEGs
| Alkyl/ether
|
Bis-PEG6-NHS ester Preparation Products And Raw materials
Raw materials
Preparation Products
Bis-PEG6-NHS ester Suppliers
View Lastest Price from Bis-PEG6-NHS ester manufacturers
- Product
- Bis-PEG6-NHS ester 1526718-98-8
- Price
- US $0.00/g
- Min. Order
- 5g
- Purity
- >98.00%
- Supply Ability
- 5g
- Release date
- 2024-03-25