Mal-amido-PEG4-TFP ester

Product Name: Mal-amido-PEG4-TFP ester
CAS No.: 1807540-84-6
Chemical Name: Mal-amido-PEG4-TFP ester
Synonyms: Mal-NH-PEG4-TFP;Mal-amido-PEG4-TFP ester;Mal-NH-PEG4-CH2CH2COOTFP;2,3,5,6-tetrafluorophenyl 1-[3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido]-3,6,9,12-tetraoxapentadecan-15-oate;4,7,10,13-Tetraoxa-16-azanonadecanoic acid, 19-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-17-oxo-, 2,3,5,6-tetrafluorophenyl ester
CBNumber: CB63062524
Molecular Formula: C24H28F4N2O9
Formula Weight: 564.48
MOL File: 1807540-84-6.mol

More

Less

Mal-amido-PEG4-TFP ester Property

storage temp.: -20°C, sealed storage, away from moisture
solubility: Soluble in DMSO, DCM, DMF
form: Viscous Liquid
color: Colorless to light yellow

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

BroadPharm

Product number: BP-22740
Product name: Mal-amido-PEG4-TFPester
Purity: 95%
Packaging: 250mg
Price: $220
Updated: 2021/12/16

dPEG

Product number: 10551
Product name: MAL-dPEG®₄-TFPester
Packaging: 1000mg
Price: $250
Updated: 2021/12/16

BroadPharm

Product number: BP-22740
Product name: Mal-amido-PEG4-TFPester
Purity: 95%
Packaging: 1g
Price: $380
Updated: 2021/12/16

Apolloscientific

Product number: BIPG1485
Product name: Mal-amido-PEG4-TFP ester
Packaging: 250mg
Price: $428
Updated: 2021/12/16

BroadPharm

Product number: BP-22740
Product name: Mal-amido-PEG4-TFPester
Purity: 95%
Packaging: 5G
Price: $1330
Updated: 2021/12/16

More

Less

Mal-amido-PEG4-TFP ester Chemical Properties,Usage,Production

Description

Mal-amido-PEG4-TFP ester is PEG linker containing a maleimide and TFP ester end group. Maleimide groups are reactive with thiols between pH 6.5 and 7.5. The TFP ester can react with primary amine groups and is also less susceptible to undergo hydrolysis compared to NHS ester. The hydrophilic PEG chains increase the water solubility of a compound in aqueous media. Longer PEG chains have improved water solubility relative to shorter PEG chains.

Uses

Mal-amido-PEG4-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs; Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005

Mal-amido-PEG4-TFP ester Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Mal-amido-PEG4-TFP ester Suppliers

China 30 United Kingdom 1 United States 4 Global 35

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354;
Email: support@targetmol.com
Country: United States
ProdList: 39035
Advantage: 58

Aladdin Scientific

Tel
Email: tp@aladdinsci.com
Country: United States
ProdList: 52923
Advantage: 58

Combi-Blocks Inc.

Tel: --
Fax: --
Email: sales@combi-blocks.com
Country: United States
ProdList: 6618
Advantage: 69

More

Less

View Lastest Price from Mal-amido-PEG4-TFP ester manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Mal-amido-PEG4-TFP ester 1807540-84-6
Price: US $0.00/g
Min. Order: 1g
Purity: >98.00%
Supply Ability: 1g
Release date: 2024-03-27

1807540-84-6, Mal-amido-PEG4-TFP esterRelated Search:

Mal-amido-PEG2-TFP ester Mal-amido-PEG12-TFP ester Mal-amido-PEG8-TFP ester

Mal-amido-PEG4-TFP ester

Mal-NH-PEG4-TFP

4,7,10,13-Tetraoxa-16-azanonadecanoic acid, 19-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-17-oxo-, 2,3,5,6-tetrafluorophenyl ester

2,3,5,6-tetrafluorophenyl 1-[3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido]-3,6,9,12-tetraoxapentadecan-15-oate

Mal-NH-PEG4-CH2CH2COOTFP

1807540-84-6

C24H28F4N2O9

peg