N-(1-Allyl-2-pyrrolidinyl)methyl-2,3-dimethoxy-5-sulfamoylbenzamide

ChemicalBook > CAS DataBase List > N-(1-Allyl-2-pyrrolidinyl)methyl-2,3-dimethoxy-5-sulfamoylbenzamide

N-(1-Allyl-2-pyrrolidinyl)methyl-2,3-dimethoxy-5-sulfamoylbenzamide

Product Name: N-(1-Allyl-2-pyrrolidinyl)methyl-2,3-dimethoxy-5-sulfamoylbenzamide
CAS No.: 66644-81-3
Chemical Name: N-(1-Allyl-2-pyrrolidinyl)methyl-2,3-dimethoxy-5-sulfamoylbenzamide
Synonyms: VERALIPRIDE;LIR166;Velaripride;N-[(1-Allyl-2-pyrrolidinyl)methyl]-5-sulphamoyl-2-veratramide;LIR 166,inhibit,Dopamine Receptor,Veralipride,Inhibitor,LIR-166;N-(1-Allyl-2-pyrrolidinyl)methyl-2,3-dimethoxy-5-sulfamoylbenzamide;N-[(1-Allylpyrrolidin-2-yl)methyl]-2,3-dimethoxy-5-sulfamoylbenzamide;2,3-diMethoxy-N-{[1-(prop-2-en-1-yl)pyrrolidin-2-yl]Methyl}-5-sulfaMoylbenzaMide;Benzamide, 5-(aminosulfonyl)-2,3-dimethoxy-N-[[1-(2-propen-1-yl)-2-pyrrolidinyl]methyl]-
CBNumber: CB6306612
Molecular Formula: C17H25N3O5S
Formula Weight: 383.46
MOL File: 66644-81-3.mol

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N-(1-Allyl-2-pyrrolidinyl)methyl-2,3-dimethoxy-5-sulfamoylbenzamide Property

Melting point:: 128 °C
Density: 1.230±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Chloroform (Slightly), DMSO (Slightly)
form: Solid
pka: 10.02±0.60(Predicted)
color: White to Off-White

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Safety

HS Code: 2935.90.6000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P322Specific measures (see …on this label).

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: V0163
Product name: Veralipride
Packaging: 10MG
Price: $136
Updated: 2024/03/01

TRC

Product number: V122500
Product name: Veralipride
Packaging: 2.5mg
Price: $150
Updated: 2021/12/16

Chem-Impex

Product number: 38361
Product name: Veralipride,≥98%(HPLC)
Purity: ≥98%(HPLC)
Packaging: 10MG
Price: $153.75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BV162329
Product name: Veralipride
Packaging: 10mg
Price: $155
Updated: 2021/12/16

ChemScene

Product number: CS-6854
Product name: Veralipride
Purity: 99.57%
Packaging: 5mg
Price: $228
Updated: 2021/12/16

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N-(1-Allyl-2-pyrrolidinyl)methyl-2,3-dimethoxy-5-sulfamoylbenzamide Chemical Properties,Usage,Production

Originator

Agreal,Delagrange,France,1980

Uses

Veralipride, a synthetic benzamide derivative with antidopaminergic action, is effective in reducing the frequency and severity of hot flashes associated with menopausal hypoestrogenism, gaining interest as a non-hormonal treatment for climacteric flushing.

Uses

Labelled Veralipride, a synthetic benzamide derivative with antidopaminergic action, is effective in reducing the frequency and severity of hot flashes associated with menopausal hypoestrogenism, gain ing interest as a non-hormonal treatment for climacteric flushing.

Definition

ChEBI: Veralipride is a sulfonamide.

Manufacturing Process

7.8 g (0.03 mol) of 2,3-dimethoxy-5-sulfamoylbenzoic acid, 200 ml of tetrahydrofuran and 7.3 g (0.045 mol) of carbonyldimidazole are placed in a 500 ml flask fitted with an agitator, a thermometer and a condenser.
The mixture is agitated for 30 minutes at normal temperature, then 6.7 g (0.948 mol) of 1-allyl-2-aminomethylpyrrolidine is added. The mixture is left under agitation for 5 hours at 20°C, then the solvent is evaporated under vacuum and the residue treated with 150 ml of water. The crystals are washed and dried.
6.9 g of N-(1'-allyl-2'-pyrrolidyl-methyl)-2,3-dimethoxy-5-sulfamoyl- benzamide is obtained. Yield is 60%; melting point 113°C to 114°C.

Therapeutic Function

Menopause treatment

N-(1-Allyl-2-pyrrolidinyl)methyl-2,3-dimethoxy-5-sulfamoylbenzamide Preparation Products And Raw materials

Raw materials

Preparation Products

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66644-81-3, N-(1-Allyl-2-pyrrolidinyl)methyl-2,3-dimethoxy-5-sulfamoylbenzamideRelated Search:

sulmepride Sulpiride 3,4-dimethoxybenzenesulfonamide 1-Allyl-2-aminomethylpyrrolidine 2,3-DIMETHOXYBENZAMIDE N-(1-Allyl-2-pyrrolidinyl)methyl-2,3-dimethoxy-5-sulfamoylbenzamide

VERALIPRIDE

N-(1-Allyl-2-pyrrolidinyl)methyl-2,3-dimethoxy-5-sulfamoylbenzamide

Velaripride

N-[(1-Allyl-2-pyrrolidinyl)methyl]-5-sulphamoyl-2-veratramide

2,3-diMethoxy-N-{[1-(prop-2-en-1-yl)pyrrolidin-2-yl]Methyl}-5-sulfaMoylbenzaMide

LIR166

Benzamide, 5-(aminosulfonyl)-2,3-dimethoxy-N-[[1-(2-propen-1-yl)-2-pyrrolidinyl]methyl]-

N-[(1-Allylpyrrolidin-2-yl)methyl]-2,3-dimethoxy-5-sulfamoylbenzamide

LIR 166,inhibit,Dopamine Receptor,Veralipride,Inhibitor,LIR-166

66644-81-3

C17H19D6N3O5S

Aromatics

Heterocycles

Intermediates & Fine Chemicals

Isotope Labelled Compounds

Pharmaceuticals

Sulfur & Selenium Compounds