N-(1-Allyl-2-pyrrolidinyl)methyl-2,3-dimethoxy-5-sulfamoylbenzamide Property

Melting point:

128 °C

Density 

1.230±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

solubility 

Chloroform (Slightly), DMSO (Slightly)

form 

Solid

pka

10.02±0.60(Predicted)

color 

White to Off-White

Safety

HS Code 

2935.90.6000

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P322Specific measures (see …on this label).

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

N-(1-Allyl-2-pyrrolidinyl)methyl-2,3-dimethoxy-5-sulfamoylbenzamide Chemical Properties,Usage,Production

Originator

Agreal,Delagrange,France,1980

Uses

Veralipride, a synthetic benzamide derivative with antidopaminergic action, is effective in reducing the frequency and severity of hot flashes associated with menopausal hypoestrogenism, gaining interest as a non-hormonal treatment for climacteric flushing.

Uses

Labelled Veralipride, a synthetic benzamide derivative with antidopaminergic action, is effective in reducing the frequency and severity of hot flashes associated with menopausal hypoestrogenism, gain ing interest as a non-hormonal treatment for climacteric flushing.

Definition

ChEBI: Veralipride is a sulfonamide.

Manufacturing Process

7.8 g (0.03 mol) of 2,3-dimethoxy-5-sulfamoylbenzoic acid, 200 ml of tetrahydrofuran and 7.3 g (0.045 mol) of carbonyldimidazole are placed in a 500 ml flask fitted with an agitator, a thermometer and a condenser.
The mixture is agitated for 30 minutes at normal temperature, then 6.7 g (0.948 mol) of 1-allyl-2-aminomethylpyrrolidine is added. The mixture is left under agitation for 5 hours at 20°C, then the solvent is evaporated under vacuum and the residue treated with 150 ml of water. The crystals are washed and dried.
6.9 g of N-(1'-allyl-2'-pyrrolidyl-methyl)-2,3-dimethoxy-5-sulfamoyl- benzamide is obtained. Yield is 60%; melting point 113°C to 114°C.

Therapeutic Function

Menopause treatment