N-(1-Allyl-2-pyrrolidinyl)methyl-2,3-dimethoxy-5-sulfamoylbenzamide
- Product Name
- N-(1-Allyl-2-pyrrolidinyl)methyl-2,3-dimethoxy-5-sulfamoylbenzamide
- CAS No.
- 66644-81-3
- Chemical Name
- N-(1-Allyl-2-pyrrolidinyl)methyl-2,3-dimethoxy-5-sulfamoylbenzamide
- Synonyms
- VERALIPRIDE;LIR166;Velaripride;N-[(1-Allyl-2-pyrrolidinyl)methyl]-5-sulphamoyl-2-veratramide;LIR 166,inhibit,Dopamine Receptor,Veralipride,Inhibitor,LIR-166;N-(1-Allyl-2-pyrrolidinyl)methyl-2,3-dimethoxy-5-sulfamoylbenzamide;N-[(1-Allylpyrrolidin-2-yl)methyl]-2,3-dimethoxy-5-sulfamoylbenzamide;2,3-diMethoxy-N-{[1-(prop-2-en-1-yl)pyrrolidin-2-yl]Methyl}-5-sulfaMoylbenzaMide;Benzamide, 5-(aminosulfonyl)-2,3-dimethoxy-N-[[1-(2-propen-1-yl)-2-pyrrolidinyl]methyl]-
- CBNumber
- CB6306612
- Molecular Formula
- C17H25N3O5S
- Formula Weight
- 383.46
- MOL File
- 66644-81-3.mol
N-(1-Allyl-2-pyrrolidinyl)methyl-2,3-dimethoxy-5-sulfamoylbenzamide Property
- Melting point:
- 128 °C
- Density
- 1.230±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Chloroform (Slightly), DMSO (Slightly)
- form
- Solid
- pka
- 10.02±0.60(Predicted)
- color
- White to Off-White
Safety
- HS Code
- 2935.90.6000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H332Harmful if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P322Specific measures (see …on this label).
P330Rinse mouth.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- V0163
- Product name
- Veralipride
- Packaging
- 10MG
- Price
- $136
- Updated
- 2024/03/01
- Product number
- V122500
- Product name
- Veralipride
- Packaging
- 2.5mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- 38361
- Product name
- Veralipride,≥98%(HPLC)
- Purity
- ≥98%(HPLC)
- Packaging
- 10MG
- Price
- $153.75
- Updated
- 2021/12/16
- Product number
- BV162329
- Product name
- Veralipride
- Packaging
- 10mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- CS-6854
- Product name
- Veralipride
- Purity
- 99.57%
- Packaging
- 5mg
- Price
- $228
- Updated
- 2021/12/16
N-(1-Allyl-2-pyrrolidinyl)methyl-2,3-dimethoxy-5-sulfamoylbenzamide Chemical Properties,Usage,Production
Originator
Agreal,Delagrange,France,1980
Uses
Veralipride, a synthetic benzamide derivative with antidopaminergic action, is effective in reducing the frequency and severity of hot flashes associated with menopausal hypoestrogenism, gaining interest as a non-hormonal treatment for climacteric flushing.
Uses
Labelled Veralipride, a synthetic benzamide derivative with antidopaminergic action, is effective in reducing the frequency and severity of hot flashes associated with menopausal hypoestrogenism, gain ing interest as a non-hormonal treatment for climacteric flushing.
Definition
ChEBI: Veralipride is a sulfonamide.
Manufacturing Process
7.8 g (0.03 mol) of 2,3-dimethoxy-5-sulfamoylbenzoic acid, 200 ml of
tetrahydrofuran and 7.3 g (0.045 mol) of carbonyldimidazole are placed in a
500 ml flask fitted with an agitator, a thermometer and a condenser.
The mixture is agitated for 30 minutes at normal temperature, then 6.7 g
(0.948 mol) of 1-allyl-2-aminomethylpyrrolidine is added. The mixture is left
under agitation for 5 hours at 20°C, then the solvent is evaporated under
vacuum and the residue treated with 150 ml of water. The crystals are washed
and dried.
6.9 g of N-(1'-allyl-2'-pyrrolidyl-methyl)-2,3-dimethoxy-5-sulfamoyl-
benzamide is obtained. Yield is 60%; melting point 113°C to 114°C.
Therapeutic Function
Menopause treatment