H-DL-ASP(OME)-OME HCL
- Product Name
- H-DL-ASP(OME)-OME HCL
- CAS No.
- 14358-33-9
- Chemical Name
- H-DL-ASP(OME)-OME HCL
- Synonyms
- DL-Asp(OMe)-OMe·HCl;H-DL-ASP(OME)-OME HCL;Asciminib Impurity 16;DL-ASPARTIC ACID(OME)-OME HCL;dl-asparticaciddimethylesterHCl;H-DL-ASP(OME)-OME HCL USP/EP/BP;dimethyl 2-aminosuccinate hydrochloride;(1,4-dimethoxy-1,4-dioxobutan-2-yl)azanium;DL-ASPARTIC ACID DIMETHYL ESTER HYDROCHLORIDE;1,4-dimethyl 2-aminobutanedioate hydrochloride
- CBNumber
- CB6309178
- Molecular Formula
- C6H12ClNO4
- Formula Weight
- 197.62
- MOL File
- 14358-33-9.mol
H-DL-ASP(OME)-OME HCL Property
- Melting point:
- 115-116.5℃ (ethanol ethyl acetate )
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- Powder
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P272Contaminated work clothing should not be allowed out of the workplace.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P321Specific treatment (see … on this label).
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D525790
- Product name
- Dl-AsparticAcidDimethylEsterHydrochloride
- Packaging
- 10g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 260705
- Product name
- DL-Aspartic acid dimethyl ester hydrochloride
- Packaging
- 10g
- Price
- $333
- Updated
- 2021/12/16
- Product number
- CS-0059285
- Product name
- DL-Asparticaciddimethylesterhydrochloride
- Purity
- >97.0%
- Packaging
- 500g
- Price
- $353
- Updated
- 2021/12/16
- Product number
- FA48715
- Product name
- DL-Aspartic acid dimethyl ester hydrochloride
- Packaging
- 100g
- Price
- $450
- Updated
- 2021/12/16
- Product number
- 06034
- Product name
- DL-Aspartic acid dimethyl ester hydrochloride
- Purity
- ≥ 98.5% (Assay: Anhydrous basis)
- Packaging
- 250G
- Price
- $495
- Updated
- 2021/12/16
H-DL-ASP(OME)-OME HCL Chemical Properties,Usage,Production
Chemical Properties
White or off-white crystal
Uses
DL-Aspartic acid dimethyl ester hydrochloride is an aspartic acid derivative[1].
Synthesis
67-56-1
1783-96-6
14358-33-9
106.8 g (0.8 mol) of D-aspartic acid and 700 ml of methanol were added to the reaction vessel, and 84.4 ml (1.2 mol) of thionyl chloride was slowly added dropwise under stirring conditions, with the reaction temperature controlled at 0 °C. After the dropwise addition, the reaction mixture was warmed up to room temperature (about 29°C) and the reaction was continued with stirring for 30 hours. Upon completion of the reaction, excess methanol and thionyl chloride were removed from the reaction solution by distillation. The remaining oily substance was dissolved in 3.5 times the volume of ether for crystallization to obtain white crystals. After filtration, the crystals were washed with ether three times and dried to finally obtain 107.8 g of white solid product DL-aspartic acid dimethyl ester hydrochloride.
Purification Methods
Crystallise it from absolute MeOH. [Kovach et al. J Am Chem Soc 107 7360 1985.] The diethyl ester has pK25 6.4.
References
[1] Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144. DOI:10.1080/10408398.2012.708368
H-DL-ASP(OME)-OME HCL Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from H-DL-ASP(OME)-OME HCL manufacturers
- Product
- H-DL-Asp(OMe)-OMe·HCl 14358-33-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1T+
- Release date
- 2024-03-21
- Product
- H-Dl-asp(ome)-ome hcl 14358-33-9
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 97.9%
- Supply Ability
- 100 tons
- Release date
- 2022-01-26
- Product
- H-DL-Asp(OMe)-OMe·HCl 14358-33-9
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2019-07-25