ChemicalBook > CAS DataBase List > H-DL-ASP(OME)-OME HCL

H-DL-ASP(OME)-OME HCL

Product Name: H-DL-ASP(OME)-OME HCL
CAS No.: 14358-33-9
Chemical Name: H-DL-ASP(OME)-OME HCL
Synonyms: DL-Asp(OMe)-OMe·HCl;H-DL-ASP(OME)-OME HCL;Asciminib Impurity 16;DL-ASPARTIC ACID(OME)-OME HCL;dl-asparticaciddimethylesterHCl;H-DL-ASP(OME)-OME HCL USP/EP/BP;dimethyl 2-aminosuccinate hydrochloride;(1,4-dimethoxy-1,4-dioxobutan-2-yl)azanium;DL-ASPARTIC ACID DIMETHYL ESTER HYDROCHLORIDE;1,4-dimethyl 2-aminobutanedioate hydrochloride
CBNumber: CB6309178
Molecular Formula: C6H12ClNO4
Formula Weight: 197.62
MOL File: 14358-33-9.mol

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H-DL-ASP(OME)-OME HCL Property

Melting point:: 115-116.5℃ (ethanol ethyl acetate )
storage temp.: Inert atmosphere,2-8°C
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: Powder
color: White to off-white

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Safety

Hazard Codes: Xi
Risk Statements: 42/43
Safety Statements: 36/37

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P321Specific treatment (see … on this label).

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: D525790
Product name: Dl-AsparticAcidDimethylEsterHydrochloride
Packaging: 10g
Price: $75
Updated: 2021/12/16

Usbiological

Product number: 260705
Product name: DL-Aspartic acid dimethyl ester hydrochloride
Packaging: 10g
Price: $333
Updated: 2021/12/16

ChemScene

Product number: CS-0059285
Product name: DL-Asparticaciddimethylesterhydrochloride
Purity: >97.0%
Packaging: 500g
Price: $353
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA48715
Product name: DL-Aspartic acid dimethyl ester hydrochloride
Packaging: 100g
Price: $450
Updated: 2021/12/16

Chem-Impex

Product number: 06034
Product name: DL-Aspartic acid dimethyl ester hydrochloride
Purity: ≥ 98.5% (Assay: Anhydrous basis)
Packaging: 250G
Price: $495
Updated: 2021/12/16

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H-DL-ASP(OME)-OME HCL Chemical Properties,Usage,Production

Chemical Properties

White or off-white crystal

Uses

DL-Aspartic acid dimethyl ester hydrochloride is an aspartic acid derivative[1].

Synthesis

67-56-1

1783-96-6

14358-33-9

106.8 g (0.8 mol) of D-aspartic acid and 700 ml of methanol were added to the reaction vessel, and 84.4 ml (1.2 mol) of thionyl chloride was slowly added dropwise under stirring conditions, with the reaction temperature controlled at 0 °C. After the dropwise addition, the reaction mixture was warmed up to room temperature (about 29°C) and the reaction was continued with stirring for 30 hours. Upon completion of the reaction, excess methanol and thionyl chloride were removed from the reaction solution by distillation. The remaining oily substance was dissolved in 3.5 times the volume of ether for crystallization to obtain white crystals. After filtration, the crystals were washed with ether three times and dried to finally obtain 107.8 g of white solid product DL-aspartic acid dimethyl ester hydrochloride.

Purification Methods

Crystallise it from absolute MeOH. [Kovach et al. J Am Chem Soc 107 7360 1985.] The diethyl ester has pK25 6.4.

References

[1] Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144. DOI:10.1080/10408398.2012.708368

H-DL-ASP(OME)-OME HCL Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from H-DL-ASP(OME)-OME HCL manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: H-DL-Asp(OMe)-OMe·HCl 14358-33-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2024-03-21

Honest Joy Holdings Limited

Product: H-Dl-asp(ome)-ome hcl 14358-33-9
Price: US $0.00/KG
Min. Order: 1KG
Purity: 97.9%
Supply Ability: 100 tons
Release date: 2022-01-26

Sichuan Jiaying Lai Technology Co.,LTD

Product: H-DL-Asp(OMe)-OMe·HCl 14358-33-9
Price: US $1.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 100KG
Release date: 2019-07-25

14358-33-9, H-DL-ASP(OME)-OME HCLRelated Search:

H-ASP(OET)-OET HCL D-ASPARTIC ACID DIMETHYL ESTER HYDROCHLORIDE Dimethyl L-aspartate hydrochloride H-ASP(OTBU)-OTBU HCL DL-Aspartic acid ASPARTIC ACID(OTBU)-ALLYL ESTER HCL H-ASP(OBZL)-OBZL HCL H-ASP(OME)-OTBU HCL H-DL-ASP(OME)-OME HCL H-ASP(OBZL)-OTBU HCL N-ALPHA-CARBOBENZOXY-L-ASPARTIC ACID BETA-T-BUTYL ESTER-ALPHA-BENZYL ESTER HYDROCHLORIDE H-D-Asp(OtBu)-OtBu · HCl FMOC-ASP(OTBU)-2-CHLOROTRITYL RESIN H-D-ASP(OTBU)-ALLYL ESTER HCL H-ASP(OTBU)-OME HCL H-DL-ASP-OME H-L-MEASP(TBU)-OME HCL METHYL 4-BENZYL-6-(3-CHLORO-4-METHOXYPHENYL)-1,3-DIOXOHEXAHYDRO-1H-FURO[3,4-C]PYRROLE-4-CARBOXYLATE

DL-ASPARTIC ACID DIMETHYL ESTER HYDROCHLORIDE

DL-ASPARTIC ACID(OME)-OME HCL

DL-ASPARTIC ACID ALPHA,BETA-DIMETHYL ESTER HYDROCHLORIDE

H-DL-ASP(OME)-OME HCL

DL-ASPARTIC ACID DIMETHYL ESTERHYDROCHLO RIDE CRYST

dl-asparticaciddimethylesterHCl

DL-Asp(OMe)-OMe·HCl

DL-ASPARTIC ACID A,B-DIMETHYLESTER HYDROCHLORIDE

DL-Aspartic acid dimethyl ester hydrochloride≥ 98.5% (Assay: Anhydrous basis)

1,4-dimethyl 2-aminobutanedioate hydrochloride

H-DL-ASP(OME)-OME HCL USP/EP/BP

(1,4-dimethoxy-1,4-dioxobutan-2-yl)azanium

dimethyl 2-aminosuccinate hydrochloride

Asciminib Impurity 16

14358-33-9