5-METHOXY-2-NITROPHENOL
- Product Name
- 5-METHOXY-2-NITROPHENOL
- CAS No.
- 704-14-3
- Chemical Name
- 5-METHOXY-2-NITROPHENOL
- Synonyms
- FR-2322;NSC 1167;TIMTEC-BB SBB008609;2-Nitro-5-methoxyphenol;5-METHOXY-2-NITROPHENOL;5-METHOZY-2-NITROPHENOL;3-Methoxy-6-nitrophenol;3-HYDROXY-4-NITROANISOLE;phenol, 5-methoxy-2-nitro-;5-methoxy-2-nitrophenolate
- CBNumber
- CB6309385
- Molecular Formula
- C7H7NO4
- Formula Weight
- 169.13
- MOL File
- 704-14-3.mol
5-METHOXY-2-NITROPHENOL Property
- Melting point:
- 92-94 °C(lit.)
- Boiling point:
- 298.4°C (rough estimate)
- Density
- 1.367
- refractive index
- 1.5830 (rough estimate)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- pka
- 6.95±0.13(Predicted)
- form
- Powder or Crystals
- color
- Yellow
- CAS DataBase Reference
- 704-14-3(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 37/38-41-36/37/38
- Safety Statements
- 26-36-37/39
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29095000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M265535
- Product name
- 5-Methoxy-2-nitrophenol
- Packaging
- 500mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- M265535
- Product name
- 5-Methoxy-2-nitrophenol
- Packaging
- 25g
- Price
- $450
- Updated
- 2021/12/16
- Product number
- 281788
- Product name
- 5-Methoxy-2-nitrophenol
- Packaging
- 5g
- Price
- $460
- Updated
- 2021/12/16
- Product number
- J53749
- Product name
- 5-Methoxy-2-nitrophenol
- Packaging
- 1g
- Price
- $15
- Updated
- 2021/12/16
- Product number
- 063641
- Product name
- 5-Methoxy-2-nitrophenol
- Purity
- 95%
- Packaging
- 5g
- Price
- $55
- Updated
- 2021/12/16
5-METHOXY-2-NITROPHENOL Chemical Properties,Usage,Production
Chemical Properties
yellow crystals or powder
Uses
5-Methoxy-2-nitrophenol is a reagent in the synthesis of conformationally constrained spirocycles, which are used as CCR1 antagonists. 5-Methoxy-2-nitrophenol is also used in the preparation of phenylsulfonyl aminophenoxybenzoates which can serve as EP1 receptor antagonists.
Synthesis Reference(s)
Synthetic Communications, 23, p. 343, 1993 DOI: 10.1080/00397919308009786
Synthesis
4920-84-7
704-14-3
The general procedure for the synthesis of 5-methoxy-2-nitrophenol from 2,4-dimethoxynitrobenzene was as follows: 2,4-dimethoxynitrobenzene (2.0 g, 10.9 mmol) was dissolved in 360 mL of dichloromethane and cooled to 0 °C. Subsequently, anhydrous aluminum trichloride (2.91 g, 21.3 mmol) was added in batches. The reaction mixture was heated to reflux and kept for 5.5 hours (the color of the reaction solution changed to bright red). After completion of the reaction, it was cooled to room temperature and 10% aqueous hydrochloric acid solution was added slowly and dropwise. The mixture was extracted three times with dichloromethane. The organic layers were combined and dried with anhydrous magnesium sulfate. After concentration under reduced pressure to remove the solvent, the crude product was purified by column chromatography (cyclohexane/ethyl acetate = 10:1) to afford 5-methoxy-2-nitrophenol (11) as a yellow solid (1.64 g, 9.69 mmol, 89% yield).
References
[1] Synthetic Communications, 2009, vol. 39, # 11, p. 2053 - 2057
[2] Synlett, 2015, vol. 26, # 10, p. 1395 - 1397
5-METHOXY-2-NITROPHENOL Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-METHOXY-2-NITROPHENOL manufacturers
- Product
- 5-methoxy-2-nitrophenol 704-14-3
- Price
- US $0.00/kg
- Min. Order
- 20kg
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2025-05-07
- Product
- 5-METHOXY-2-NITROPHENOL 704-14-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-01-03
- Product
- 5-METHOXY-2-NITROPHENOL 704-14-3
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 98%min
- Supply Ability
- 20kg/month
- Release date
- 2019-11-05