ChemicalBook > CAS DataBase List > 5-METHOXY-2-NITROPHENOL

5-METHOXY-2-NITROPHENOL

Product Name
5-METHOXY-2-NITROPHENOL
CAS No.
704-14-3
Chemical Name
5-METHOXY-2-NITROPHENOL
Synonyms
FR-2322;NSC 1167;TIMTEC-BB SBB008609;2-Nitro-5-methoxyphenol;5-METHOXY-2-NITROPHENOL;5-METHOZY-2-NITROPHENOL;3-Methoxy-6-nitrophenol;3-HYDROXY-4-NITROANISOLE;phenol, 5-methoxy-2-nitro-;5-methoxy-2-nitrophenolate
CBNumber
CB6309385
Molecular Formula
C7H7NO4
Formula Weight
169.13
MOL File
704-14-3.mol
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5-METHOXY-2-NITROPHENOL Property

Melting point:
92-94 °C(lit.)
Boiling point:
298.4°C (rough estimate)
Density 
1.367
refractive index 
1.5830 (rough estimate)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
pka
6.95±0.13(Predicted)
form 
Powder or Crystals
color 
Yellow
CAS DataBase Reference
704-14-3(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
37/38-41-36/37/38
Safety Statements 
26-36-37/39
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29095000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
M265535
Product name
5-Methoxy-2-nitrophenol
Packaging
500mg
Price
$50
Updated
2021/12/16
TRC
Product number
M265535
Product name
5-Methoxy-2-nitrophenol
Packaging
25g
Price
$450
Updated
2021/12/16
Usbiological
Product number
281788
Product name
5-Methoxy-2-nitrophenol
Packaging
5g
Price
$460
Updated
2021/12/16
ChemScene
Product number
CS-W000056
Product name
5-Methoxy-2-nitrophenol
Purity
>98.0%
Packaging
25g
Price
$116
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
JK372089
Product name
5-Methoxy-2-nitrophenol
Purity
98%
Packaging
1g
Price
$153
Updated
2021/12/16
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5-METHOXY-2-NITROPHENOL Chemical Properties,Usage,Production

Chemical Properties

yellow crystals or powder

Uses

5-Methoxy-2-nitrophenol is a reagent in the synthesis of conformationally constrained spirocycles, which are used as CCR1 antagonists. 5-Methoxy-2-nitrophenol is also used in the preparation of phenylsulfonyl aminophenoxybenzoates which can serve as EP1 receptor antagonists.

Synthesis Reference(s)

Synthetic Communications, 23, p. 343, 1993 DOI: 10.1080/00397919308009786

Synthesis

4920-84-7

704-14-3

The general procedure for the synthesis of 5-methoxy-2-nitrophenol from 2,4-dimethoxynitrobenzene was as follows: 2,4-dimethoxynitrobenzene (2.0 g, 10.9 mmol) was dissolved in 360 mL of dichloromethane and cooled to 0 °C. Subsequently, anhydrous aluminum trichloride (2.91 g, 21.3 mmol) was added in batches. The reaction mixture was heated to reflux and kept for 5.5 hours (the color of the reaction solution changed to bright red). After completion of the reaction, it was cooled to room temperature and 10% aqueous hydrochloric acid solution was added slowly and dropwise. The mixture was extracted three times with dichloromethane. The organic layers were combined and dried with anhydrous magnesium sulfate. After concentration under reduced pressure to remove the solvent, the crude product was purified by column chromatography (cyclohexane/ethyl acetate = 10:1) to afford 5-methoxy-2-nitrophenol (11) as a yellow solid (1.64 g, 9.69 mmol, 89% yield).

References

[1] Synthetic Communications, 2009, vol. 39, # 11, p. 2053 - 2057
[2] Synlett, 2015, vol. 26, # 10, p. 1395 - 1397

5-METHOXY-2-NITROPHENOL Preparation Products And Raw materials

Raw materials

Preparation Products

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5-METHOXY-2-NITROPHENOL Suppliers

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View Lastest Price from 5-METHOXY-2-NITROPHENOL manufacturers

Qingdao RENAS Polymer Material Co., Ltd.
Product
5-methoxy-2-nitrophenol 704-14-3
Price
US $0.00/kg
Min. Order
20kg
Purity
99%
Supply Ability
20 tons
Release date
2025-05-07
Career Henan Chemical Co
Product
5-METHOXY-2-NITROPHENOL 704-14-3
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2020-01-03
Nanjing jinheyou Trading Co., Ltd.
Product
5-METHOXY-2-NITROPHENOL 704-14-3
Price
US $0.00/g
Min. Order
1g
Purity
98%min
Supply Ability
20kg/month
Release date
2019-11-05

704-14-3, 5-METHOXY-2-NITROPHENOLRelated Search:

3-CHLORO-2,6-DIMETHOXY-5-NITROBENZOIC ACID EOSIN B 2,6-DIMETHOXY-3-NITROBENZOIC ACID 2,4-Dimethoxy-1-nitrobenzene 1,3,5-TRIMETHOXY-2-NITROBENZENE 5-METHOXY-2-NITROPHENOL Methyl 2-nitro-3,4,5-trimethoxybenzoate EOSIN B Oxyfluorfen 2-METHOXY-5-NITROPHENOL,5 nitroguaiacol, 2-methoxy-5-nitrophenol,2-Methoxy-5-nitrophenol 98%,2-METHOXY-5-NITROPHENOL / 5-NITROGUAIACOL 2-BROMO-4-METHOXY-6-NITROPHENOL SODIUM 2-METHOXY-5-NITROPHENOL,2-METHOXY-5-NITROPHENOL SODIUM SALT 2-METHOXY-4-NITROPHENOL,o-Methoxy-p-nitrophenol 4-METHOXY-2-NITROPHENOL,4-METHOXY-2-NITROPHENOL, TECH. 2-methoxy-4-nitrophenol potassium salt 4-Nitroanisole 3,4,5-TRIMETHOXY-2-NITROBENZOIC ACID 1-chloro-2,4-dimethoxy-5-nitrobenzene

  • TIMTEC-BB SBB008609
  • 5-METHOXY-2-NITROPHENOL 98%
  • 5-METHOZY-2-NITROPHENOL
  • 5-METHOXY-2-NITROPHENOL
  • 3-HYDROXY-4-NITROANISOLE
  • phenol, 5-methoxy-2-nitro-
  • 2-Hydroxy-4-methoxynitrobenzene, 3-Hydroxy-4-nitrotoluene
  • 5-Methoxy-2-nitrophenol, 98% 1GR
  • 2-Nitro-5-methoxyphenol
  • 5-Methoxy-2-nitrophenol,98%
  • 5-methoxy-2-nitrophenolate
  • 2-Hydroxy-4-methoxynitrobenzene
  • 3-Methoxy-6-nitrophenol
  • NSC 1167
  • FR-2322
  • 704-14-3
  • Oxygen Compounds
  • Phenols
  • Organic Building Blocks
  • Building Blocks
  • Aromatic Phenols
  • Organic Building Blocks
  • Oxygen Compounds
  • Phenols
  • Building Blocks
  • C6 to C8
  • Chemical Synthesis
  • Organic Building Blocks
  • Oxygen Compounds