IMR-1
- Product Name
- IMR-1
- CAS No.
- 310456-65-6
- Chemical Name
- IMR-1
- Synonyms
- IMR-1;IMR-1 (IMR1;IMR-1, >98%;IMR-1 >=98% (HPLC);IMR-1, 10 mM in DMSO;IMR 1,IMR1,IMR-1,Notch,Inhibitor,inhibit;Ethyl 2-(2-methoxy-4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenoxy)acetate;ethyl (e)-2-(2-methoxy-4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenoxy)acetate;[2-Methoxy-4-[(4-oxo-2-thioxo-5-thiazolidinylidene)methyl]phenoxy]acetic acid ethyl ester;2-Methoxy-4-(4-oxo-2-thioxo-thiazolidin-5-ylidenemethyl)-phenoxy]-acetic acid ethyl ester
- CBNumber
- CB63133187
- Molecular Formula
- C15H15NO5S2
- Formula Weight
- 353.41
- MOL File
- 310456-65-6.mol
IMR-1 Property
- storage temp.
- 2-8°C(protect from light)
- solubility
- Soluble in DMSO (up to 45 mg/ml) or in Ethanol (up to 9 mg/ml with warming).
- form
- solid
- color
- Yellow
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- SML1812
- Product name
- IMR-1
- Purity
- ≥98% (HPLC)
- Packaging
- 5 mg
- Price
- $117
- Updated
- 2025/07/31
- Product number
- SML1812
- Product name
- IMR-1
- Purity
- ≥98% (HPLC)
- Packaging
- 25 mg
- Price
- $477
- Updated
- 2025/07/31
- Product number
- 27920
- Product name
- IMR-1
- Packaging
- 5mg
- Price
- $68
- Updated
- 2024/03/01
- Product number
- 27920
- Product name
- IMR-1
- Packaging
- 10mg
- Price
- $121
- Updated
- 2024/03/01
- Product number
- 27920
- Product name
- IMR-1
- Packaging
- 25mg
- Price
- $268
- Updated
- 2024/03/01
IMR-1 Chemical Properties,Usage,Production
Description
Inhibitor of Mastermind Recruitment-1 (IMR-1, 310456-65-6) disrupts the recruitment of Mastermind-like 1 to the Notch transcriptional activation complex (NTC) on chromatin, which attenuates Notch target gene transcription.1?IC50=26 μM (in vitro assay). IMR-1 inhibits the growth of Notch-dependent cell lines and attenuates the growth of patient-derived tumor xenografts. The ethyl ester is hydrolyzed by intracellular esterases which produces the free acid compound (IMR-1A), IC50=0.5 μM (in vitro?assay). Binding of IMR-1 to NTC is non-covalent and reversible.1
Uses
IMR-1 is a novel class of Notch inhibitor targeting the transcriptional activation with an IC50 of 26 μM. IMR-1 prevents the recruitment of Mastermind-like 1 (Maml1) to the Notch Ternary Complex (NTC) on chromatin, inhibits Notch target gene transcription and dramatically inhibits tumor growth[1].
in vitro
in order to determine the effect of imr-1 on the assembly of the notch ternary complex (ntc) in cells, notch-dependent cell lines oe33 and 786-0 were treated with imr-1 or dapt. results showed that treatment of oe33 and 786-0 with imr-1 could decrease the occupancy of maml1 on the hes1 promoter but, in contrast to dapt, imr-1 treatment could not affect the occupancy of notch1 on the hes1 promoter. in addition, western blot analyses indicated that imr-1 treatment did not change the cellular levels of nicd [1].
in vivo
animal study showed that treatment of mice with 15 mg/kg imr-1 could readily block tumor establishment. moreover, imr-1 treatment at 15 mg/kg caused no observable adverse effects on the animal. in two independent pdx models, imr-1 could significantly abrogate the tumor growth to a similar level achieved with dapt treatment, without any significant weight loss or other visible signs of adverse effects in the treated mice [1].
IC 50
26 μmol/l
References
[1] LUISANA ASTUDILLO. The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis.[J]. Cancer research, 2016, 76 12: 3593-3603. DOI:10.1158/0008-5472.can-16-0061
IMR-1 Preparation Products And Raw materials
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View Lastest Price from IMR-1 manufacturers
- Product
- IMR-1 310456-65-6
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000kg
- Release date
- 2020-01-12