GSK484

Product Name: GSK484
CAS No.: 1652591-81-5
Chemical Name: GSK484
Synonyms: GSK484;CS-2265;AOB6992;GTPL8577;GSK484 HCl;GSK484 >=98% (HPLC);PAD4 inhibitor GS484;PAD4 inhibitor GSK484;GSK484 (hydrochloride);GSK484 hydrochloride,GSK 484,Protein Arginine Deiminase,GSK-484,GSK-484 hydrochloride,GSK484,inhibit,Peptidylarginine Deiminase,Inhibitor
CBNumber: CB63146499
Molecular Formula: C27H32ClN5O3
Formula Weight: 510.04
MOL File: 1652591-81-5.mol

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GSK484 Property

storage temp.: 2-8°C
solubility: DMSO:25.0(Max Conc. mg/mL);49.01(Max Conc. mM)
Ethanol:25.0(Max Conc. mg/mL);49.01(Max Conc. mM)
PBS buffer (pH 7.2):5.0(Max Conc. mg/mL);9.8(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);58.82(Max Conc. mM)
form: powder
color: white to beige
InChIKey: MULKOGJHUZTANI-JEGYXLSDNA-N
SMILES: C(C1CC1)N1C2=CC=CC=C2C=C1C1=NC2=CC(C(N3CC[C@@H](O)[C@@H](N)C3)=O)=CC(OC)=C2N1C.Cl |&1:22,24,r|

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1658
Product name: GSK484
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $346
Updated: 2023/06/20

Sigma-Aldrich

Product number: SML1658
Product name: GSK484
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $1350
Updated: 2023/06/20

Cayman Chemical

Product number: 17488
Product name: GSK484 (hydrochloride)
Purity: ≥95%
Packaging: 500μg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 17488
Product name: GSK484 (hydrochloride)
Purity: ≥95%
Packaging: 1mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 17488
Product name: GSK484 (hydrochloride)
Purity: ≥95%
Packaging: 5mg
Price: $283
Updated: 2024/03/01

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GSK484 Chemical Properties,Usage,Production

Description

GSK484 is a reversible inhibitor of PAD4 (IC₅₀ = 50 nM) that binds to the low-calcium form of the enzyme. It is selective for PAD4 over PAD1-3. GSK484 blocks the citrullination of PAD4 target proteins in human neutrophils and inhibits the formation of neutrophil extracellular traps in both mouse and human neutrophils. It exhibits favorable pharmacokinetic profiles in mouse and rat. See the Structural Genomics Consortium (SGC) website for more information.

Uses

GSK484 is a novel selective PAD4 inhibitor.

Biochem/physiol Actions

GSK484 is a potent selective reversible inhibitor of protein arginine deiminase PAD4, an enzyme believed to play a role in granulocyte and macrophage development leading to inflammation and immune response, and overexpressed in many tumors. GSK484 has IC50 values of 50 nM without calcium and 250 nM in the presence of 2 mM calcium. GSK484 showed minimal off-target activity tested against 50 other proteins with no activation across HDACs 1–11 even at 100 μM. GSK484 binds at a different site from the amidines, a conformation of the PAD4 active site where part of the site is reordered to form a β-hairpin.

GSK484 Preparation Products And Raw materials

Raw materials

Preparation Products

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GSK484 Suppliers

China 84 India 1 United States 7 Global 92

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

TargetMol Chemicals Inc.

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Email: support@targetmol.com
Country: United States
ProdList: 38631
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

Cayman Chemical Company

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Fax: --
Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

United States Biological

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Email: chemicals@usbio.net
Country: United States
ProdList: 6214
Advantage: 80

MedChemExpress

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Email: sales@medchemexpress.com
Country: United States
ProdList: 6398
Advantage: 58

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View Lastest Price from GSK484 manufacturers

Hubei Chuchang Biotech Co., Ltd.

Product: GSK484 (hydrochloride) 1652591-81-5
Price: US $0.00-0.00/mg
Min. Order: 1mg
Purity: 98%
Supply Ability: 100G
Release date: 2024-04-17

1652591-81-5, GSK484Related Search:

GSK J4 HCl GSK 2334470 GSK2982772 GSK2636771 Benzeneacetamide, α-[[6-(4-amino-1-piperidinyl)-3,5-dicyano-4-ethyl-2-pyridinyl]thio]- GSK778 N-(6-Fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-[4-(trifluoromethyl)phenyl]-1,4,5,6-tetrahydro-3-pyridinecarboxamide RET Kinase inhibitor 1 N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-3-methyl-6-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxamide GSK583 GSK369796 GSK461364 GSK547 GSK-467 GSK481 GSK-3326595 GSK864 S)-1-(sec-butyl)-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-3-Methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxaMide

GSK484

GSK484 (hydrochloride)

CS-2265

PAD4 inhibitor GS484

GSK484 HCl

((3S,4R)-3-amino-4-hydroxypiperidin-1-yl)(2-(1-(cyclopropylmethyl)-1H-indol-2-yl)-7-methoxy-1-methyl-1H-benzo[d]imidazol-5-yl)methanone hydrochloride

AOB6992

GTPL8577

GSK484 >=98% (HPLC)

PAD4 inhibitor GSK484

GSK484 hydrochloride,GSK 484,Protein Arginine Deiminase,GSK-484,GSK-484 hydrochloride,GSK484,inhibit,Peptidylarginine Deiminase,Inhibitor

((3S,4R)-3-Amino-4-hydroxypiperidin-1-yl)(2-(1-(cyclopropylmethyl)-1H-indol-2-yl)-7-methoxy-1-methyl-1H-benzo[d]imidazol-5-yl)methanone hydrochloride , GSK484 HCl

1652591-81-5

652591-81-5

C27H31N5O3ClH