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Edoxaban-d6

Product Name
Edoxaban-d6
CAS No.
1304701-57-2
Chemical Name
Edoxaban-d6
Synonyms
Edoxaban-d6;[2H6]-Edoxaban;Edoxaban hydrochloride salt;N-[(1S,2R,4S)-4-[bis(trideuteriomethyl)carbamoyl]-2-[(5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-2-carbonyl)amino]cyclohexyl]-N'-(5-chloropyridin-2-yl)oxamide
CBNumber
CB63163409
Molecular Formula
C24H30ClN7O4S
Formula Weight
548.06
MOL File
1304701-57-2.mol
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Edoxaban-d6 Property

Melting point:
>205°C (dec.)
storage temp. 
Hygroscopic, Refrigerator, under inert atmosphere
solubility 
Chloroform (Slightly), Dichloromethane (Slightly)
form 
Solid
color 
Pale Orange to Pale Red
Stability:
Hygroscopic
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
25760
Product name
Edoxaban-d6
Purity
≥99% deuterated forms (d1-d6)
Packaging
500μg
Price
$396
Updated
2024/03/01
Cayman Chemical
Product number
25760
Product name
Edoxaban-d6
Purity
≥99% deuterated forms (d1-d6)
Packaging
1mg
Price
$711
Updated
2024/03/01
Usbiological
Product number
448076
Product name
Edoxaban-d6
Packaging
500ug
Price
$531
Updated
2021/12/16
TRC
Product number
E555522
Product name
Edoxaban-d6
Packaging
5mg
Price
$1850
Updated
2021/12/16
AK Scientific
Product number
4287DK
Product name
N-[(1S,2R,4S)-4-[Bis(trideuteriomethyl)carbamoyl]-2-[(5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-2-carbonyl)amino]cyclohexyl]-N'-(5-chloropyridin-2-yl)oxamide
Packaging
1mg
Price
$889
Updated
2021/12/16
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Edoxaban-d6 Chemical Properties,Usage,Production

Description

Edoxaban-d6 is intended for use as an internal standard for the quantification of edoxaban by GC- or LC-MS. Edoxaban is an orally bioavailable and potent inhibitor of factor Xa (Kis = 0.561 and 0.903 nM for free and complexed human factor Xa, respectively). It is >10,000-fold selective for factor Xa over thrombin, FVIIa/sTF, FXIa, tPA, aPC, trypsin, plasmin, and chymotrypsin. Edoxaban prolongs prothrombin, activated partial thromboplastin, and thrombin clotting times in a concentration-dependent manner ex vivo in human plasma. Oral administration of edoxaban (0.5-12.5 mg/kg) reduces thrombus formation and prolongs prothrombin time in a dose-dependent manner in rat and rabbit models of venous stasis thrombosis. It also reduces thrombus formation in a rat model of platinum wire-induced venous thrombosis. Formulations containing edoxaban have been used to prevent stroke in patients with atrial fibrillation.

Uses

Edoxaban-d6 is the isotope labelled analog of Edoxaban (E555520); an anticoagulant drug which acts as a direct factor Xa inhibitor.

Edoxaban-d6 Preparation Products And Raw materials

Raw materials

Preparation Products

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Edoxaban-d6 Suppliers

Clearsynth Canada Inc.
Tel
+1.415.685.4395
Fax
+1.415.685.4395
Email
enquiry@clearsynth.com
Country
Canada
ProdList
912
Advantage
58

1304701-57-2, Edoxaban-d6Related Search:


  • Edoxaban-d6
  • N-[(1S,2R,4S)-4-[bis(trideuteriomethyl)carbamoyl]-2-[(5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-2-carbonyl)amino]cyclohexyl]-N'-(5-chloropyridin-2-yl)oxamide
  • [2H6]-Edoxaban
  • Edoxaban hydrochloride salt
  • 1304701-57-2