2-BroMo-5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine

Product Name: 2-BroMo-5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine
CAS No.: 143150-92-9
Chemical Name: 2-BroMo-5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine
Synonyms: Edoxaban Impurity 64;2-Bromo-5-methyl-4H,6H,7H-[1,3]thiazolo[5,4-c]pyridine;2-bromo-5-methyl-4H,5H,6H,7H-[1,3]thiazolo[5,4-c]pyridine;2-BroMo-5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine;2-bromo-4,5,6,7-tetrahydro-5-methyl-Thiazolo[5,4-c]pyridine;2-bromo-5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine;Thiazolo[5,4-c]pyridine, 2-broMo-4,5,6,7-tetrahydro-5-Methyl-;2-BroMo-5-Methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine
CBNumber: CB02629588
Molecular Formula: C7H9BrN2S
Formula Weight: 233.13
MOL File: 143150-92-9.mol

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2-BroMo-5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine Property

Boiling point:: 286.4±30.0 °C(Predicted)
Density: 1.594±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Acetonitrile (Slightly), Chloroform (Slightly)
pka: 6.41±0.20(Predicted)
form: Solid
color: Grey

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B809005
Product name: 2-bromo-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine
Packaging: 100mg
Price: $75
Updated: 2021/12/16

TRC

Product number: B809005
Product name: 2-bromo-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine
Packaging: 500mg
Price: $245
Updated: 2021/12/16

AK Scientific

Product number: CS-0041774
Product name: 2-Bromo-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine
Packaging: 1g
Price: $93
Updated: 2021/12/16

SynQuest Laboratories

Product number: 7H70-9-15
Product name: 2-Bromo-5-methyl-4H,6H,7H-[1,3]thiazolo[5,4-c]pyridine
Packaging: 250mg
Price: $125
Updated: 2021/12/16

SynQuest Laboratories

Product number: 7H70-9-15
Product name: 2-Bromo-5-methyl-4H,6H,7H-[1,3]thiazolo[5,4-c]pyridine
Packaging: 1g
Price: $375
Updated: 2021/12/16

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2-BroMo-5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine Chemical Properties,Usage,Production

Synthesis

17899-48-8

143150-92-9

5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-amine (12) (600.0 g, 3.545 mol) was used as a raw material and suspended in water (6.0 L). 48% hydrobromic acid (4.2 L) was added slowly and dropwise at 0 to 15 °C. Subsequently, a solution of sodium nitrite (367.2 g, 3.56 mol) in water (1.8 L) was added dropwise over 1.5 to 5 hours. After the dropwise addition, the reaction mixture was heated to 30°C and stirred continuously for 24 hours. After completion of the reaction, the reaction mixture was neutralized with 5N aqueous sodium hydroxide solution (6.0 L) to a strong base (pH = 12.5). Then, the aqueous layer was extracted with toluene (12.0 L and 6.0 L) in two batches. The toluene layers were combined and dried by adding anhydrous sodium sulfate (1202.0 g). After filtration to remove insoluble matter, the mother liquor was concentrated under reduced pressure at 40 °C to afford the target product 2-bromo-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine (11a) (557.6 g, 67.5% yield). The product was characterized by 1H-NMR (CDCl3): δppm 3.58-3.57 (t, 3H, J = 1.8Hz), 2.92-2.87 (m, 2H), 2.81-2.76 (m, 2H), 2.49 (s, 3H).

References

[1] Patent: US2013/144061, 2013, A1. Location in patent: Paragraph 0248; 0249; 0250
[2] Patent: EP1683800, 2006, A1. Location in patent: Page/Page column 56
[3] Patent: US2017/50983, 2017, A1. Location in patent: Paragraph 0142; 0143; 0144; 0145; 0146

2-BroMo-5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-BroMo-5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine Suppliers

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View Lastest Price from 2-BroMo-5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 2-Bromo-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine 143150-92-9
Price: US $2.00-6.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-07-30

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 2-Bromo-5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine 143150-92-9
Price: US $0.00/G
Min. Order: 10G
Purity: 98%min
Supply Ability: 30kg/month
Release date: 2023-01-29

Shaanxi Dideu New Materials Co. Ltd

Product: 2-BroMo-5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine 143150-92-9
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-03-06

143150-92-9, 2-BroMo-5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridineRelated Search:

Polyacrylamide Chitosan Gelatin Edoxaban Impurity 45 Edoxaban Impurity 38 2-(((1S,2R,4S)-4-(dimethylcarbamoyl)-2-(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamido)cyclohexyl)amino)-2-oxoacetic acid carbamic acid, n-[(1r,2r,5s)-5-[(dimethylamino)carbonyl]-2-hydroxycyclohexyl]-, 1,1-dimethylethyl ester EthanediaMide, N1-(5-chlo... edoxaban (1S,3R,4S)-4-(2-((5-chloropyridin- 2-yl)amino)-2-oxoacetamido)-3-(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamido)cyclohexane-1-carboxylic acid (1R,2R,4S)-2-[(tert-butoxycarbonyl)aMino]-4-[(diMethylaMino)carbonyl]cyclohexyl Methanesulfonate tert-Butyl [(1R,2S,5S)-2-amino-5-[(dimethylamino)carbonyl]cyclohexyl]carbamate oxalate Ethyl 2-((5-chloropyridin-2-yl)amino)-2-oxoacetate hydrochloride (1R,3S,4R)-3-Amino-4-hydroxy-cyclohexanecarboxylic acid ethyl ester hydrochloride Edoxaban Impurity 37 Edoxaban Impurity 42 2-Amino-5-chloropyridine Clanfenur

2-BroMo-5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine

Thiazolo[5,4-c]pyridine, 2-broMo-4,5,6,7-tetrahydro-5-Methyl-

2-bromo-5-methyl-4H,5H,6H,7H-[1,3]thiazolo[5,4-c]pyridine

2-bromo-4,5,6,7-tetrahydro-5-methyl-Thiazolo[5,4-c]pyridine

2-bromo-5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine

2-BroMo-5-Methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine

2-Bromo-5-methyl-4H,6H,7H-[1,3]thiazolo[5,4-c]pyridine

Edoxaban Impurity 64

143150-92-9