2-BroMo-5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine

Product Name: 2-BroMo-5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine
CAS No.: 143150-92-9
Chemical Name: 2-BroMo-5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine
Synonyms: Edoxaban Impurity 64;2-Bromo-5-methyl-4H,6H,7H-[1,3]thiazolo[5,4-c]pyridine;2-bromo-5-methyl-4H,5H,6H,7H-[1,3]thiazolo[5,4-c]pyridine;2-BroMo-5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine;2-bromo-4,5,6,7-tetrahydro-5-methyl-Thiazolo[5,4-c]pyridine;2-bromo-5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine;Thiazolo[5,4-c]pyridine, 2-broMo-4,5,6,7-tetrahydro-5-Methyl-;2-BroMo-5-Methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine
CBNumber: CB02629588
Molecular Formula: C7H9BrN2S
Formula Weight: 233.13
MOL File: 143150-92-9.mol

More

Less

2-BroMo-5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine Property

Boiling point:: 286.4±30.0 °C(Predicted)
Density: 1.594±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Acetonitrile (Slightly), Chloroform (Slightly)
pka: 6.41±0.20(Predicted)
form: Solid
color: Grey

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

TRC

Product number: B809005
Product name: 2-bromo-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine
Packaging: 100mg
Price: $75
Updated: 2021/12/16

TRC

Product number: B809005
Product name: 2-bromo-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine
Packaging: 500mg
Price: $245
Updated: 2021/12/16

AK Scientific

Product number: CS-0041774
Product name: 2-Bromo-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine
Packaging: 1g
Price: $93
Updated: 2021/12/16

SynQuest Laboratories

Product number: 7H70-9-15
Product name: 2-Bromo-5-methyl-4H,6H,7H-[1,3]thiazolo[5,4-c]pyridine
Packaging: 250mg
Price: $125
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0419463
Product name: 2-BROMO-5-METHYL-4H,5H,6H,7H-[1,3]THIAZOLO[5,4-C]PYRIDINE
Purity: 95.00%
Packaging: 5MG
Price: $457.53
Updated: 2021/12/16

More

Less

2-BroMo-5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine Chemical Properties,Usage,Production

Synthesis

17899-48-8

143150-92-9

5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-amine (12) (600.0 g, 3.545 mol) was used as a raw material and suspended in water (6.0 L). 48% hydrobromic acid (4.2 L) was added slowly and dropwise at 0 to 15 °C. Subsequently, a solution of sodium nitrite (367.2 g, 3.56 mol) in water (1.8 L) was added dropwise over 1.5 to 5 hours. After the dropwise addition, the reaction mixture was heated to 30°C and stirred continuously for 24 hours. After completion of the reaction, the reaction mixture was neutralized with 5N aqueous sodium hydroxide solution (6.0 L) to a strong base (pH = 12.5). Then, the aqueous layer was extracted with toluene (12.0 L and 6.0 L) in two batches. The toluene layers were combined and dried by adding anhydrous sodium sulfate (1202.0 g). After filtration to remove insoluble matter, the mother liquor was concentrated under reduced pressure at 40 °C to afford the target product 2-bromo-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine (11a) (557.6 g, 67.5% yield). The product was characterized by 1H-NMR (CDCl3): δppm 3.58-3.57 (t, 3H, J = 1.8Hz), 2.92-2.87 (m, 2H), 2.81-2.76 (m, 2H), 2.49 (s, 3H).

References

[1] Patent: US2013/144061, 2013, A1. Location in patent: Paragraph 0248; 0249; 0250
[2] Patent: EP1683800, 2006, A1. Location in patent: Page/Page column 56
[3] Patent: US2017/50983, 2017, A1. Location in patent: Paragraph 0142; 0143; 0144; 0145; 0146

2-BroMo-5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

2-BroMo-5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine Suppliers

China 107 India 3 United States 5 Global 115

PharmaBlock Sciences (Nanjing),Inc.

Tel: 025-86918202 4000255188
Fax: 86-025-86918232
Email: sales@pharmablock.com
Country: China
ProdList: 5000
Advantage: 55

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14101
Advantage: 59

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 15883
Advantage: 64

Tongchuang Pharma(Suzhou). Co., Ltd.

Tel: 0512-63263366 18912765016
Fax: 0512-6326 3366
Email: tongtf110@sina.com
Country: China
ProdList: 993
Advantage: 62

Shanghai T&W Pharmaceutical Co., Ltd.

Tel: +86 21 61551611
Fax: +86 21 50676805
Country: China
ProdList: 9891
Advantage: 58

Shanghai Keepontech Co.,Ltd

Tel: 021-54849683 13601642561
Fax: +86-21-54375689
Email: sales@keepontech.com
Country: China
ProdList: 998
Advantage: 59

SuZhou ShiYa Biopharmaceuticals, Inc.

Tel: 86(512)5235 8471 17715136450
Fax: 86(512)5235 6881
Email: sales@shiyabiopharm.com
Country: China
ProdList: 4169
Advantage: 58

CEG Chemical Science&Technology Co., Ltd.

Tel: Mobile:13665161512
Fax: +86-510-68873513
Country: China
ProdList: 1785
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

More

Less

View Lastest Price from 2-BroMo-5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 2-Bromo-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine 143150-92-9
Price: US $2.00-6.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-07-30

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 2-Bromo-5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine 143150-92-9
Price: US $0.00/G
Min. Order: 10G
Purity: 98%min
Supply Ability: 30kg/month
Release date: 2023-01-29

Shaanxi Dideu New Materials Co. Ltd

Product: 2-BroMo-5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine 143150-92-9
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-03-06

143150-92-9, 2-BroMo-5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridineRelated Search:

Polyacrylamide Chitosan Gelatin Edoxaban Impurity 45 Edoxaban Impurity 38 2-(((1S,2R,4S)-4-(dimethylcarbamoyl)-2-(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamido)cyclohexyl)amino)-2-oxoacetic acid carbamic acid, n-[(1r,2r,5s)-5-[(dimethylamino)carbonyl]-2-hydroxycyclohexyl]-, 1,1-dimethylethyl ester EthanediaMide, N1-(5-chlo... edoxaban (1S,3R,4S)-4-(2-((5-chloropyridin- 2-yl)amino)-2-oxoacetamido)-3-(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamido)cyclohexane-1-carboxylic acid (1R,2R,4S)-2-[(tert-butoxycarbonyl)aMino]-4-[(diMethylaMino)carbonyl]cyclohexyl Methanesulfonate tert-Butyl [(1R,2S,5S)-2-amino-5-[(dimethylamino)carbonyl]cyclohexyl]carbamate oxalate Ethyl 2-((5-chloropyridin-2-yl)amino)-2-oxoacetate hydrochloride (1R,3S,4R)-3-Amino-4-hydroxy-cyclohexanecarboxylic acid ethyl ester hydrochloride Edoxaban Impurity 37 Edoxaban Impurity 42 2-Amino-5-chloropyridine Clanfenur

2-BroMo-5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine

Thiazolo[5,4-c]pyridine, 2-broMo-4,5,6,7-tetrahydro-5-Methyl-

2-bromo-5-methyl-4H,5H,6H,7H-[1,3]thiazolo[5,4-c]pyridine

2-bromo-4,5,6,7-tetrahydro-5-methyl-Thiazolo[5,4-c]pyridine

2-bromo-5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine

2-BroMo-5-Methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine

2-Bromo-5-methyl-4H,6H,7H-[1,3]thiazolo[5,4-c]pyridine

Edoxaban Impurity 64

143150-92-9