ChemicalBook > CAS DataBase List > 1-(4-Nitrophenyl)piperazine

1-(4-Nitrophenyl)piperazine

Product Name
1-(4-Nitrophenyl)piperazine
CAS No.
6269-89-2
Chemical Name
1-(4-Nitrophenyl)piperazine
Synonyms
AKOS BBS-00003599;Piperazine-Ph-NO2;RARECHEM AH CK 0146;TIMTEC-BB SBB003475;LABOTEST-BB LT00076049;1-(P-NITROPHENYL)PIPERAZINE;1-(4-NITROPHENYL)PIPERAZINE;1-Nitro-4-piperazinobenzene;N-(4-NITROPHENYL)PIPERAZINE;N-(P-NITROPHENYL) PIPERAZINE
CBNumber
CB6322746
Molecular Formula
C10H13N3O2
Formula Weight
207.23
MOL File
6269-89-2.mol
More
Less

1-(4-Nitrophenyl)piperazine Property

Melting point:
131-133 °C (lit.)
Boiling point:
346.25°C (rough estimate)
Density 
1.1933 (rough estimate)
refractive index 
1.4830 (estimate)
storage temp. 
Storage temp. 2-8°C
form 
Crystalline Powder, Crystals and/or Chunks
pka
8.68±0.10(Predicted)
color 
White to beige to gray
InChI
InChI=1S/C10H13N3O2/c14-13(15)10-3-1-9(2-4-10)12-7-5-11-6-8-12/h1-4,11H,5-8H2
InChIKey
VWOJSRICSKDKAW-UHFFFAOYSA-N
SMILES
N1(C2=CC=C([N+]([O-])=O)C=C2)CCNCC1
CAS DataBase Reference
6269-89-2(CAS DataBase Reference)
NIST Chemistry Reference
N-p-nitrophenylpiperazine(6269-89-2)
More
Less

Safety

Hazard Codes 
Xn,Xi
Risk Statements 
20/21/22-36/37/38
Safety Statements 
26-37/39-24/25-36
RIDADR 
2811
WGK Germany 
3
Hazard Note 
Irritant
HazardClass 
6.1
PackingGroup 
III
HS Code 
29335990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
279773
Product name
1-(4-Nitrophenyl)piperazine
Purity
97%
Packaging
5g
Price
$75.62
Updated
2025/07/31
TCI Chemical
Product number
N0694
Product name
1-(4-Nitrophenyl)piperazine
Purity
>98.0%(T)
Packaging
5g
Price
$29
Updated
2025/07/31
TCI Chemical
Product number
N0694
Product name
1-(4-Nitrophenyl)piperazine
Purity
>98.0%(T)
Packaging
25g
Price
$81
Updated
2025/07/31
TRC
Product number
N504510
Product name
1-(4-Nitrophenyl)piperazine
Packaging
25g
Price
$140
Updated
2021/12/16
Apolloscientific
Product number
OR6870
Product name
1-(4-Nitrophenyl)piperazine
Purity
97%
Packaging
5g
Price
$21
Updated
2021/12/16
More
Less

1-(4-Nitrophenyl)piperazine Chemical Properties,Usage,Production

Chemical Properties

yellow to ochre powder

Uses

1-(4-Nitrophenyl)piperazine is a useful synthetic intermediate in the synthesis of Itraconazole (I937500); an orally active antimycotic structurally related to Ketoconazole. Also antifungal.

General Description

Inclusion interactions of 1-(4-nitrophenyl)piperazine with 4-sulfonatocalix[n]arenes were investigated by UV spectroscopy and fluorescence spectroscopy.

Synthesis

110-85-0

100-00-5

6269-89-2

A solution of 1-chloro-4-nitrobenzene (650 g, 4.140 mol) in diethylene glycol dimethyl ether (1 L) was slowly added dropwise to a solution of piperazine (2.84 Kg, 33.12 mol) in diethylene glycol dimethyl ether (500 mL) at 100 °C. The reaction mixture was stirred continuously at 100°C for 6 hours. Upon completion of the reaction, the mixture was cooled to 40-45 °C and water (5 L) was slowly added to quench the reaction. Subsequently, the mixture was warmed to room temperature and stirring was continued for 1 hour. The precipitated solid was collected by filtration, washed sequentially with water (1 L) and petroleum ether (500 mL), and dried to give 700 g (81% yield) of 4-nitrophenylpiperazine as a yellow solid. [TLC detection conditions: ethyl acetate:petroleum ether (3:7); Rf value: 0.70].

References

[1] Tetrahedron Letters, 1999, vol. 40, # 31, p. 5655 - 5659
[2] Organic Letters, 2016, vol. 18, # 20, p. 5272 - 5275
[3] Patent: WO2016/79536, 2016, A1. Location in patent: Page/Page column 34-35
[4] Patent: WO2017/203270, 2017, A1. Location in patent: Page/Page column 30; 33; 34
[5] Patent: WO2018/45106, 2018, A1. Location in patent: Paragraph 00133

1-(4-Nitrophenyl)piperazine Preparation Products And Raw materials

Raw materials

Preparation Products

4-(1-Acetylpiperazin-4-yl)phenol
More
Less

1-(4-Nitrophenyl)piperazine Suppliers

Americas 1 Belgium 1 Canada 1 China 167 Europe 3 Germany 10 India 22 Italy 1 Japan 8 Poland 1 Russia 1 Slovakia 1 Switzerland 3 The Netherlands 1 Ukraine 1 United Kingdom 18 United States 53 Global 293
Beijing Haite lesk Technology Co., Ltd
Tel
15210893940; 15116916250
Fax
QQ: 237008221
Email
chemistryliu@163.com
Country
China
ProdList
7327
Advantage
58
Huaian Jiamu Biotechnology Co., Ltd.
Tel
0517-83187139 18205232085
Email
cai@jiamu-bio.com
Country
China
ProdList
2990
Advantage
58
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15838
Advantage
69
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2338
Advantage
56
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Shijiazhuang Sdyano Fine Chemical Co., Ltd.
Tel
0311-89250318 031166536426
Fax
4000311741
Email
master@sjzsdyn.com
Country
China
ProdList
2805
Advantage
65
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
Advantage
56
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
Advantage
66
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.
Tel
+86-21-54098501
Fax
+86-21-54096319
Email
sales@sinch.com.cn
Country
China
ProdList
11598
Advantage
64
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd.
Tel
21-57721279
Fax
QQ：14057904
Email
sales@shydchem.com.cn
Country
China
ProdList
998
Advantage
56
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9883
Advantage
59
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
Chembon Pharmaceutical Co., Ltd.
Tel
028-84252981
Fax
+86-28-84252965
Email
sales@chembon.com.cn
Country
China
ProdList
850
Advantage
64
Shanghai Feibo Chemical Technology Co., Ltd
Tel
021-58955608,2250286 15921236618
Email
blinkzeng@gmail.com
Country
China
ProdList
522
Advantage
62
Wuhan Luohua Medical Technology Co.,Ltd.
Tel
13477084141; 13477084141
Fax
+86(27)65566697
Email
sales@luohuapharm.com
Country
China
ProdList
468
Advantage
60
Changzhou Kangte Pharmtech Co.,Ltd
Tel
0519-82813797 18994752886
Fax
0519-82813703
Email
czkangte@hotmail.com
Country
China
ProdList
45
Advantage
62
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
Advantage
57
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7811
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14435
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9815
Advantage
79
T&W GROUP
Tel
021-61551611 13296011611
Fax
＋86 21-50676805
Email
contact@trustwe.com
Country
China
ProdList
9895
Advantage
58
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17770
Advantage
75
Cantotech Chemicals, Ltd.
Tel
86-0755-86635001
Fax
86-0755-22642228
Email
cantotech@126.com
Country
China
ProdList
4566
Advantage
55
Shanghai Raise Chemical Technology Co.,Ltd
Tel
+86-021-50935922
Fax
+86-021-33847795
Country
China
ProdList
7865
Advantage
55
Amatek Scientific Co. Ltd.
Tel
0512-56316828 4008675858
Fax
+86-512-56316826
Email
sales@amateksci.com
Country
China
ProdList
9874
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
Shanghai Balmxy Pharmaceutical Co., Ltd
Tel
021-24206007 13764915196
Fax
86-021-23027023
Email
sales@balmxy.com
Country
China
ProdList
6874
Advantage
55
Credit-Chem Co., Ltd.
Tel
400-821-5857 021-64326257
Fax
021-64393586 QQ;2798200800
Email
credit-chem@foxmail.com
Country
China
ProdList
5219
Advantage
58
Wuhan Dahua Pharmaceutical Co., Ltd.
Tel
027-59262863 13277907145 3091977954
Fax
027-59420980
Country
China
ProdList
4942
Advantage
58
Shanghai YuLue Chemical Co., Ltd.
Tel
021-60345187 13671753212
Fax
021-34702061
Email
lzz841106@aliyun.com
Country
China
ProdList
10263
Advantage
55
Shanghai Xingui Biotechnology Co., Ltd.
Tel
15121041756
Email
xingui2022@126.com
Country
China
ProdList
9979
Advantage
58
Shanghai Jovan Biochemical Technology Co. Ltd.
Tel
+86-021-61654350
Fax
+86-021-61654350
Email
1245958370@qq.com
Country
China
ProdList
2982
Advantage
50
Shanghai Song Yuan Chemical Technology Co., Ltd.
Tel
010-1234567 18521000990
Fax
86-021-33275113
Email
sonyuanchemical@163.com
Country
China
ProdList
6479
Advantage
50
Nanjing Chalf-Pharm Technology Co., Ltd.
Tel
025-57018978 18251899859
Fax
025-57018008
Email
sales@chalf-pharm.com
Country
China
ProdList
5674
Advantage
50
Credit Asia Chemical Co., Ltd.
Tel
+86 (21) 61124340
Fax
+86 (21) 6129-4103
Country
China
ProdList
9756
Advantage
58
Cool Pharm, Ltd
Tel
021-60455363 18019463053
Fax
50966098
Email
sales@coolpharm.com
Country
China
ProdList
12346
Advantage
58
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51395
Advantage
80
AN PharmaTech Co Ltd
Tel
86(21)68097365
Fax
86(21)33321566
Email
sales@anpharma.net
Country
China
ProdList
4891
Advantage
55
Giant chemicals
Tel
028-85434334 18108076537
Fax
QQ：245797092
Email
market@gianthx.com
Country
China
ProdList
4505
Advantage
56
Zhengzhou Alfachem Co., Ltd.
Tel
0371-53765687 18937137882
Fax
QQ:2885373884
Email
2853979813@qq.com
Country
China
ProdList
7991
Advantage
55
Shanghai Qiao Chemical Science Co., Ltd
Tel
021-58892003
Email
info@qiaochem.com
Country
China
ProdList
6059
Advantage
65
Shijiazhuang Sdyano Fine Chemical Co., Ltd.
Tel
0311-89250318 031166536426
Fax
4000311741
Email
master@sjzsdyn.com
Country
China
ProdList
3495
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Shanghai QianYan Bio-technology Co., Ltd
Tel
02781293128
Email
orders@biochemsafebuy.com
Country
China
ProdList
9923
Advantage
55
Changzhou Hopschain Chemical Co.,Ltd.
Tel
0519-85528066 13775048983
Fax
0519-85528066
Email
sales@hopschem.com
Country
China
ProdList
31553
Advantage
55
More
Less

View Lastest Price from 1-(4-Nitrophenyl)piperazine manufacturers

ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Palbociclib Impurity 14 6269-89-2
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
98%
Supply Ability
500mg
Release date
2024-08-12
Shaanxi Dideu New Materials Co. Ltd
Product
1-(4-Nitrophenyl)piperazine 6269-89-2
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-02-19
Zhuozhou Wenxi import and Export Co., Ltd
Product
1-(4-Nitrophenyl)piperazine 6269-89-2
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-11

6269-89-2, 1-(4-Nitrophenyl)piperazineRelated Search:

1-Phenyl-2-nitropropene N-Aminoethylpiperazine Piperacillin 2-Ethylhexyl ferulate Piperazine 1-(2-CHLORO-4-NITROPHENYL)-PIPERAZINE 4-Nitro-7-(1-piperazinyl)-2,1,3-benzoxadiazole Propiophenone 1-Acetyl-4-(4-nitrophenyl)piperazine 1-METHYL-4-(4-NITROPHENYL)PIPERAZINE 1-(3-Nitrophenyl)piperazin-2-one 1-(4-METHOXYPHENYL)-4-(4-NITROPHENYL)PIPERAZINE 1-Methyl-4-(3-nitrophenyl)piperazine ,97% 1-(3-NITROPHENYL)-PIPERAZINE 1-(4-HYDROXYPHENYL)-4-(4-NITROPHENYL)-PIPERAZINE 1-(2,4-DINITROPHENYL)-PIPERAZINE HCL 1-(2-NITROPHENYL)PIPERAZINE,1-(2-Nitrophenyl)piperazine ,98% 1-(2-CHLORO-4-NITROPHENYL)-3-METHYLPIPERAZINE HYDROCHLORIDE

  • Piperazine-Ph-NO2
  • 1-(4-nitrophenyl)piperazin-4-ium
  • AKOS BBS-00003599
  • 1-(P-NITROPHENYL)PIPERAZINE
  • 1-NITRO-4-(1-PIPERAZINYL)BENZENE
  • 1-(4-NITROPHENYL)PIPERAZINE
  • 1-(4-NITRO-PHENYL)-PIPERAZINE DIHYDROCHLORIDE
  • 1-(4-NITROPHENYL)PIPERAZINE HCL
  • LABOTEST-BB LT00076049
  • 1-(4-Nitrophenyl)piperazine 97%
  • N-(P-NITROPHENYL) PIPERAZINE
  • 1-(4-Nitrophenyl)piperazine, 98+%
  • 1-Nitro-4-piperazinobenzene
  • 1-Nitro-4-(piperazin-1-yl)benzene, 4-(Piperazin-1-yl)nitrobenzene
  • Piperazine, 1-(4-nitrophenyl)-
  • N-(4-NITROPHENYL)PIPERAZINE
  • RARECHEM AH CK 0146
  • TIMTEC-BB SBB003475
  • 1-(4-Nitrophenyl)piperazine&gt
  • 4-Nitrophenyl piperazine, 97%
  • 1-(4-Nitrophenyl)piperazine - [N93451]
  • 6269-89-2
  • C10H14N3O2
  • C0H13N3O2
  • AMINE
  • Building Blocks
  • Heterocyclic Building Blocks
  • Piperazines
  • CHIRAL CHEMICALS
  • Phenyls & Phenyl-Het
  • Building Blocks
  • Heterocyclic Building Blocks
  • Piperazines
  • Nitrogen cyclic compounds
  • Piperidines, Piperidones, Piperazines
  • pharmacetical
  • Phenyls & Phenyl-Het
  • Piperaizine
  • API intermediates