1-(4-Nitrophenyl)piperazine

Product Name: 1-(4-Nitrophenyl)piperazine
CAS No.: 6269-89-2
Chemical Name: 1-(4-Nitrophenyl)piperazine
Synonyms: AKOS BBS-00003599;Piperazine-Ph-NO2;RARECHEM AH CK 0146;TIMTEC-BB SBB003475;LABOTEST-BB LT00076049;1-(P-NITROPHENYL)PIPERAZINE;1-(4-NITROPHENYL)PIPERAZINE;1-Nitro-4-piperazinobenzene;N-(4-NITROPHENYL)PIPERAZINE;N-(P-NITROPHENYL) PIPERAZINE
CBNumber: CB6322746
Molecular Formula: C10H13N3O2
Formula Weight: 207.23
MOL File: 6269-89-2.mol

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1-(4-Nitrophenyl)piperazine Property

Melting point:: 131-133 °C (lit.)
Boiling point:: 346.25°C (rough estimate)
Density: 1.1933 (rough estimate)
refractive index: 1.4830 (estimate)
storage temp.: Storage temp. 2-8°C
form: Crystalline Powder, Crystals and/or Chunks
pka: 8.68±0.10(Predicted)
color: White to beige to gray
InChI: InChI=1S/C10H13N3O2/c14-13(15)10-3-1-9(2-4-10)12-7-5-11-6-8-12/h1-4,11H,5-8H2
InChIKey: VWOJSRICSKDKAW-UHFFFAOYSA-N
SMILES: N1(C2=CC=C([N+]([O-])=O)C=C2)CCNCC1
CAS DataBase Reference: 6269-89-2(CAS DataBase Reference)
NIST Chemistry Reference: N-p-nitrophenylpiperazine(6269-89-2)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 20/21/22-36/37/38
Safety Statements: 26-37/39-24/25-36
RIDADR: 2811
WGK Germany: 3
Hazard Note: Irritant
HazardClass: 6.1
PackingGroup: III
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 279773
Product name: 1-(4-Nitrophenyl)piperazine
Purity: 97%
Packaging: 5g
Price: $75.62
Updated: 2025/07/31

TCI Chemical

Product number: N0694
Product name: 1-(4-Nitrophenyl)piperazine
Purity: >98.0%(T)
Packaging: 5g
Price: $29
Updated: 2025/07/31

TCI Chemical

Product number: N0694
Product name: 1-(4-Nitrophenyl)piperazine
Purity: >98.0%(T)
Packaging: 25g
Price: $81
Updated: 2025/07/31

TRC

Product number: N504510
Product name: 1-(4-Nitrophenyl)piperazine
Packaging: 25g
Price: $140
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0016876
Product name: 1-(4-NITRO PHENYL )PIPERAZINE
Purity: 95.00%
Packaging: 10G
Price: $142.8
Updated: 2021/12/16

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1-(4-Nitrophenyl)piperazine Chemical Properties,Usage,Production

Chemical Properties

yellow to ochre powder

Uses

1-(4-Nitrophenyl)piperazine is a useful synthetic intermediate in the synthesis of Itraconazole (I937500); an orally active antimycotic structurally related to Ketoconazole. Also antifungal.

General Description

Inclusion interactions of 1-(4-nitrophenyl)piperazine with 4-sulfonatocalix[n]arenes were investigated by UV spectroscopy and fluorescence spectroscopy.

Synthesis

110-85-0

100-00-5

6269-89-2

A solution of 1-chloro-4-nitrobenzene (650 g, 4.140 mol) in diethylene glycol dimethyl ether (1 L) was slowly added dropwise to a solution of piperazine (2.84 Kg, 33.12 mol) in diethylene glycol dimethyl ether (500 mL) at 100 °C. The reaction mixture was stirred continuously at 100°C for 6 hours. Upon completion of the reaction, the mixture was cooled to 40-45 °C and water (5 L) was slowly added to quench the reaction. Subsequently, the mixture was warmed to room temperature and stirring was continued for 1 hour. The precipitated solid was collected by filtration, washed sequentially with water (1 L) and petroleum ether (500 mL), and dried to give 700 g (81% yield) of 4-nitrophenylpiperazine as a yellow solid. [TLC detection conditions: ethyl acetate:petroleum ether (3:7); Rf value: 0.70].

References

[1] Tetrahedron Letters, 1999, vol. 40, # 31, p. 5655 - 5659
[2] Organic Letters, 2016, vol. 18, # 20, p. 5272 - 5275
[3] Patent: WO2016/79536, 2016, A1. Location in patent: Page/Page column 34-35
[4] Patent: WO2017/203270, 2017, A1. Location in patent: Page/Page column 30; 33; 34
[5] Patent: WO2018/45106, 2018, A1. Location in patent: Paragraph 00133

1-(4-Nitrophenyl)piperazine Preparation Products And Raw materials

Raw materials

Preparation Products

4-(1-Acetylpiperazin-4-yl)phenol

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1-(4-Nitrophenyl)piperazine Suppliers

Americas 1 Belgium 1 Canada 1 China 166 Europe 3 Germany 10 India 22 Italy 1 Japan 8 Poland 1 Russia 1 Slovakia 1 Switzerland 3 The Netherlands 1 Ukraine 1 United Kingdom 18 United States 53 Global 292

GLR Innovations

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View Lastest Price from 1-(4-Nitrophenyl)piperazine manufacturers

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Palbociclib Impurity 14 6269-89-2
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 98%
Supply Ability: 500mg
Release date: 2024-08-12

Shaanxi Dideu New Materials Co. Ltd

Product: 1-(4-Nitrophenyl)piperazine 6269-89-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-02-19

Zhuozhou Wenxi import and Export Co., Ltd

Product: 1-(4-Nitrophenyl)piperazine 6269-89-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

6269-89-2, 1-(4-Nitrophenyl)piperazineRelated Search:

1-Phenyl-2-nitropropene N-Aminoethylpiperazine Piperacillin 2-Ethylhexyl ferulate Piperazine 1-(2-CHLORO-4-NITROPHENYL)-PIPERAZINE 4-Nitro-7-(1-piperazinyl)-2,1,3-benzoxadiazole Propiophenone 1-Acetyl-4-(4-nitrophenyl)piperazine 1-METHYL-4-(4-NITROPHENYL)PIPERAZINE 1-(3-Nitrophenyl)piperazin-2-one 1-(4-METHOXYPHENYL)-4-(4-NITROPHENYL)PIPERAZINE 1-Methyl-4-(3-nitrophenyl)piperazine ,97% 1-(3-NITROPHENYL)-PIPERAZINE 1-(4-HYDROXYPHENYL)-4-(4-NITROPHENYL)-PIPERAZINE 1-(2,4-DINITROPHENYL)-PIPERAZINE HCL 1-(2-NITROPHENYL)PIPERAZINE,1-(2-Nitrophenyl)piperazine ,98% 1-(2-CHLORO-4-NITROPHENYL)-3-METHYLPIPERAZINE HYDROCHLORIDE

Piperazine-Ph-NO2

1-(4-nitrophenyl)piperazin-4-ium

AKOS BBS-00003599

1-(P-NITROPHENYL)PIPERAZINE

1-NITRO-4-(1-PIPERAZINYL)BENZENE

1-(4-NITROPHENYL)PIPERAZINE

1-(4-NITRO-PHENYL)-PIPERAZINE DIHYDROCHLORIDE

1-(4-NITROPHENYL)PIPERAZINE HCL

LABOTEST-BB LT00076049

1-(4-Nitrophenyl)piperazine 97%

N-(P-NITROPHENYL) PIPERAZINE

1-(4-Nitrophenyl)piperazine, 98+%

1-Nitro-4-piperazinobenzene

1-Nitro-4-(piperazin-1-yl)benzene, 4-(Piperazin-1-yl)nitrobenzene

Piperazine, 1-(4-nitrophenyl)-

N-(4-NITROPHENYL)PIPERAZINE

RARECHEM AH CK 0146

TIMTEC-BB SBB003475

1-(4-Nitrophenyl)piperazine&gt

4-Nitrophenyl piperazine, 97%

1-(4-Nitrophenyl)piperazine - [N93451]

6269-89-2

C10H14N3O2

C0H13N3O2

AMINE

Building Blocks

Heterocyclic Building Blocks

Piperazines

CHIRAL CHEMICALS

Phenyls & Phenyl-Het

Building Blocks

Heterocyclic Building Blocks

Piperazines

Nitrogen cyclic compounds

Piperidines, Piperidones, Piperazines

pharmacetical

Phenyls & Phenyl-Het

Piperaizine

API intermediates