CYTOCHALASIN B
- Product Name
- CYTOCHALASIN B
- CAS No.
- 14930-96-2
- Chemical Name
- CYTOCHALASIN B
- Synonyms
- cytochalasin;PHOMIN;-23-one;CYTOCHALACINB;CYTOCHALICINB;CYTOCHALASIN B;CYTOCHALASIN B(RG);Cytochalasin B (Phomin);CYTOCHALASIN B USP/EP/BP;(7s,13e,16r,20r,21e)-0-phenyl
- CBNumber
- CB6323824
- Molecular Formula
- C29H37NO5
- Formula Weight
- 479.61
- MOL File
- 14930-96-2.mol
CYTOCHALASIN B Property
- Melting point:
- 218-223 °C
- Boiling point:
- 577.96°C (rough estimate)
- Density
- 1.1490 (rough estimate)
- refractive index
- 1.6290 (estimate)
- Flash point:
- 85℃
- storage temp.
- -20°C
- solubility
- ethanol: 20 mg/mL
- form
- powder
- pka
- 13.60±0.70(Predicted)
- color
- white
- Merck
- 13,2819
- BRN
- 1096207
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
- InChIKey
- UXVDBQLLXVKPRS-UZBFCAAUSA-N
- LogP
- 3.370
- EPA Substance Registry System
- Cytochalasin B (14930-96-2)
Safety
- Hazard Codes
- T+,T
- Risk Statements
- 26/27/28-63-23/24/25
- Safety Statements
- 28-36/37-45
- RIDADR
- UN 1544 6.1/PG 2
- WGK Germany
- 3
- RTECS
- RO0205000
- F
- 10
- HazardClass
- 6.1(a)
- PackingGroup
- I
- HS Code
- 29349990
- Hazardous Substances Data
- 14930-96-2(Hazardous Substances Data)
- Toxicity
- LD50 intraperitoneal in mouse: 30mg/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H361Suspected of damaging fertility or the unborn child
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- C2743
- Product name
- Cytochalasin B from Drechslera dematioidea
- Purity
- Ready Made Solution, 10?mg/mL in DMSO, 0.2 μm filtered
- Packaging
- 200μL
- Price
- $154
- Updated
- 2024/03/01
- Product number
- 250233
- Product name
- Cytochalasin B,
- Packaging
- 5mg
- Price
- $208
- Updated
- 2024/03/01
- Product number
- J65342
- Product name
- Cytochalasin B
- Packaging
- 5mg
- Price
- $273
- Updated
- 2024/03/01
- Product number
- J65342
- Product name
- Cytochalasin B
- Packaging
- 10mg
- Price
- $431
- Updated
- 2024/03/01
- Product number
- 11328
- Product name
- Cytochalasin B
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
CYTOCHALASIN B Chemical Properties,Usage,Production
Description
Cytochalasin B (14930-96-2) is a cell permeable fungal toxin which binds to the barbed end of actin, inhibiting its polymerization.1 Inhibits cell division, migration and glucose transport.2 Causes cell cycle arrest at G2/M and induces apoptosis in HCT-116 colorectal carcinoma cells.3? Cytochalasin B-induced membrane vesicles (CIMVs) retain cell surface receptors of the parent cells and retain fusion specificity with target cells.4 CIMVs are a promising new vector system for drug and biomolecule delivery due to their natural origin and participation in intercellular communication.5
Chemical Properties
white to off-white powder
Uses
Cytochalasin B is one of the most extensively studied members of a family of potent mycotoxins produced by several species of fungi. All members of the class exhibit profound effects on cytoskeletal proteins, giving rise to pronounced morphogenic activity in animals and plants. Like most cytochalsins, cytochalasin B exhibits potent inhibition of actin filament function leading to cell death by apoptosis, and displays a broad range of resultant cellular actions. Despite the common mode of action, there is evidence that individual members of this class display diverse selectivity. However, lack of comparative co-metabolite analysis has restricted a more complete understanding of their individual selectivity.
Uses
A cell-permeable fungal toxin used in actin polymerization studies and cytological
Uses
As tools in cytological research and in characterization of polymerization properties of actin, q.v.
Definition
ChEBI: An organic heterotricyclic compound, that is a mycotoxin which is cell permeable an an inhibitor of cytoplasmic division by blocking the formation of contractile microfilaments.
General Description
Cytochalasin B is a cell-permeable fungal toxin / mycotoxin that binds to the ′barbed′ end of actin / actin filaments. This binding leads to:
- Disruption of actin filaments and of interaction of actin filaments in solution
- Inhibition of actin polymerization
- Inhibition of subunit association and dissociation
Biochem/physiol Actions
Cell permeable fungal toxin that disrupts contractile microfilaments by inhibiting actin polymerization. This, in turn, induces DNA fragmentation, inhibits cell division, and disrupts many cell processes. Inhibits glucose transport.
storage
Store at -20°C
Purification Methods
Purify it by MeOH extraction, reverse phase C18 silica gel batch extraction by selective elution with 1:1 v/v hexane/tetrahydrofuran, crystallisation, subjected to TLC and recrystallisation [Lipski et al. Anal Biochem 161 332 1987]. It is soluble in EtOH (3.6%), Me2CO (1%), Me2SO (37%) and Me2NCHO (49%) at 24o, and can be crystallised from the first two solvents. It interferes with cellular movement [Korm Physiol Reviews 62 672 1982].
References
Threadoropoulos et al. (1994), Cytochalasin B may shorten actin filaments by a mechanism independent of barbed end capping; Biochem. Pharmacol., 47 1875 Whitesell et al. (2005), Compartmentalization of transport and phosphorylation of glucose in a hepatoma cell line; Biochem. J., 386 245 Buldak et al. (2014), Changes in subcellular localization of visfatin in human colorectal HCT-116 carcinoma cell line after cytochalasin B treatment; Eur. J. Histochem., 58 2408 Gomzikova et al. (2018), Evaluation of cytochalasin B-Induced Membrane Vesicles Fusion specificity with Target Cells; Biomed. Res. Int., 2018 7053623 Gomzikova et al. (2017), Cytochalasin B-induced membrane vesicles convey angiogenic activity of parental cells; Oncotarget, 8 70496
CYTOCHALASIN B Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from CYTOCHALASIN B manufacturers
- Product
- CYTOCHALASIN B 14930-96-2
- Price
- US $1.00/ASSAYS
- Min. Order
- 1ASSAYS
- Purity
- 98%
- Supply Ability
- 1kg,2kg,100kg
- Release date
- 2019-07-09