ChemicalBook > CAS DataBase List > Bisindolylmaleimide V

Bisindolylmaleimide V

Product Name
Bisindolylmaleimide V
CAS No.
113963-68-1
Chemical Name
Bisindolylmaleimide V
Synonyms
RO 31-6045;BISINDOLYLMALEIMIDE V;Sotrastaurin Impurity 12;n-methylbis(indol-3-yl)maleimide;BisindolylMaleiMide V [Ro 31-6045];1-METHYL-3,4-BIS(3-INDOLYL)MALEIMIDE;1-METHYL-3,4-BIS(INDOL-3-YL)MALEIMIDE;2,3-Di(1H-Indol-3-yl)-N-methylmaleimide;2,3-BIS(1H-INDOL-3-YL)-N-METHYLMALEIMIDE;3,4-Di-1H-indol-3-yl-1-methyl-1H-pyrrole-2,5-dione
CBNumber
CB6329851
Molecular Formula
C21H15N3O2
Formula Weight
341.36
MOL File
113963-68-1.mol
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Bisindolylmaleimide V Property

Melting point:
>260 °C
Boiling point:
655.7±55.0 °C(Predicted)
Density 
1.450±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
DMSO: soluble
form 
solid
pka
15.89±0.30(Predicted)
color 
Orange
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
CAS DataBase Reference
113963-68-1(CAS DataBase Reference)
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
203303
Product name
Bisindolylmaleimide V - CAS 113963-68-1 - Calbiochem
Purity
A cell-permeable negative control compound for protein kinase C inhibition studies (IC?? >100 μM).
Packaging
400μG
Price
$68.9
Updated
2023/01/07
Sigma-Aldrich
Product number
203303
Product name
Bisindolylmaleimide V - CAS 113963-68-1 - Calbiochem
Packaging
1mg
Price
$223
Updated
2023/01/07
Cayman Chemical
Product number
13300
Product name
Bisindolylmaleimide V
Purity
≥98%
Packaging
1mg
Price
$64
Updated
2024/03/01
Cayman Chemical
Product number
13300
Product name
Bisindolylmaleimide V
Purity
≥98%
Packaging
5mg
Price
$280
Updated
2024/03/01
Cayman Chemical
Product number
13300
Product name
Bisindolylmaleimide V
Purity
≥98%
Packaging
10mg
Price
$497
Updated
2024/03/01
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Bisindolylmaleimide V Chemical Properties,Usage,Production

Description

Ro 31-6045 (113963-68-1) is a bis indolylmaleimide derivative that is a potent inhibitor of the mitogen-stimulated protein kinase p70 (S6K) acting independently of its upstream activator mTOR.1?Does not inhibit PKC (at concentrations <100?mM) and therefore may be used as a negative control for bisindolylmaleimide PKC inhibitors2?such as GF 109203X3?and other structurally related inhibitors4.

Definition

ChEBI: Ro 31-6045 is a member of indoles.

References

1) Marmy-Conus?et al.?(2002),?Ro 31-6045, the inactive analogue of the protein kinase C inhibitor Ro 31-8220, blocks in vivo activation of p70(s6k)/p85(s6k): implications for the analysis of S6K signalling; FEBS Lett.,?519?135 2) Harmon?et al.?(1997),?Bisindolylmaleimide protein-kinase C inhibitors delay in the decline in DNA synthesis in mouse hair follicle organ cultures; Skin Pharmacol.,?10?71 3) Toullec?et al.?(1991),?The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C; J. Biol. Chem.,?266?15771 4) Davis?et al. (1992),?Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides; J. Med. Chem.,?35?177

Bisindolylmaleimide V Preparation Products And Raw materials

Raw materials

Preparation Products

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Bisindolylmaleimide V Suppliers

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113963-68-1, Bisindolylmaleimide VRelated Search:

Succinimide 2-Methylindole Thiophanate-methyl Kresoxim-methyl N-Ethylmaleimide N-Phenylmaleimide N-Benzylmaleimide Pyrrole Methyl salicylate Methyl acetate Maleimide Tribenuron methyl METSULFURON METHYL Bismaleimide O-Phthalimide Methyl Polyamideimide DIALIFOS

  • 1-Methyl-3,4-bis(indol-3-yl)maleimide, Ro 31-6045
  • 1-Methyl 3,4-bis(1H-indole-3-yl)-3-pyrroline-2,5-dione
  • 1-Methyl-3-(1H-indole-3-yl)-4-(1H-indole-3-yl)-1H-pyrrole-2,5-dione
  • 1-Methyl-3,4-bis(1H-indole-3-yl)-3-pyrroline-2,5-dione
  • 3,4-Bis(1H-indol-3-yl)-1-methyl-1H-pyrrole-2,5-dione
  • 3,4-Bis(1H-indole-3-yl)-1-methyl-3-pyrroline-2,5-dione
  • Bisindolylmaleimide V - CAS 113963-68-1 - Calbiochem
  • BISINDOLYLMALEIMIDE V
  • 3,4-Di-1H-indol-3-yl-1-methyl-1H-pyrrole-2,5-dione
  • BisindolylMaleiMide V [Ro 31-6045]
  • bisindolylmaleimide v:1-methyl-3,4-bis(3-indolyl)maleimide
  • RO 31-6045
  • 2,3-BIS(1H-INDOL-3-YL)-N-METHYLMALEIMIDE
  • 1-METHYL-3,4-BIS(3-INDOLYL)MALEIMIDE
  • 1-METHYL-3,4-BIS(INDOL-3-YL)MALEIMIDE
  • 3,4-BIS-(1H-INDOL-3-YL)-1-METHYL-PYRROLE-2,5-DIONE
  • n-methylbis(indol-3-yl)maleimide
  • 1H-Pyrrole-2,5-dione, 3,4-di-1H-indol-3-yl-1-methyl-
  • 2,3-Di(1H-Indol-3-yl)-N-methylmaleimide
  • Bisindolylmaleimide V,inhibit,Ribosomal S6 Kinase (RSK),Inhibitor,BIM V,S6K
  • Sotrastaurin Impurity 12
  • 113963-68-1
  • C21H15N3O2
  • BioChemical
  • Cell Signaling and Neuroscience
  • Cell Biology
  • Protein Kinase Inhibitors
  • Protein Phosphorylation