3-[5-[2-[(2-Methoxyethyl)methylamino]ethoxy]-1H-indol-2-yl]-2(1H)-quinolinone

Product Name: 3-[5-[2-[(2-Methoxyethyl)methylamino]ethoxy]-1H-indol-2-yl]-2(1H)-quinolinone
CAS No.: 408502-06-7
Chemical Name: 3-[5-[2-[(2-Methoxyethyl)methylamino]ethoxy]-1H-indol-2-yl]-2(1H)-quinolinone
Synonyms: KDR-in-4;VEGFR-2-IN-9;VEGFR 2 IN 9,VEGFR2IN9;3-[5-[2-[(2-Methoxyethyl)methylamino]ethoxy]-1H-indol-2-yl]-2(1H)-quinolinone;2(1H)-Quinolinone, 3-[5-[2-[(2-methoxyethyl)methylamino]ethoxy]-1H-indol-2-yl]-
CBNumber: CB63339581
Molecular Formula: C23H25N3O3
Formula Weight: 391.4629
MOL File: 408502-06-7.mol

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3-[5-[2-[(2-Methoxyethyl)methylamino]ethoxy]-1H-indol-2-yl]-2(1H)-quinolinone Property

Melting point:: 204-205 °C
Boiling point:: 651.5±55.0 °C(Predicted)
Density: 1.235±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
pka: 11.55±0.70(Predicted)

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Hazard and Precautionary Statements (GHS)

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3-[5-[2-[(2-Methoxyethyl)methylamino]ethoxy]-1H-indol-2-yl]-2(1H)-quinolinone Chemical Properties,Usage,Production

Uses

VEGFR-2-IN-9 (KDR-in-4) is a potent kinase insert domain-containing receptor (KDR/VEGFR2) inhibitor with an IC50 of 7 nM.

in vivo

KDR-in-4 may prove to be useful for the treatment of a variety of ocular neovascular diseases using a convenient oral dosing regimen. At doses of 100 mg/kg, KDR-in-4 results in a 98% reduction in lesion size in the rat choroidal neovascularization (CNV) model. 30 mg/kg doses of KDR-in-4 shows a 70% and 80% reduction in lesion size in the laser CNV and rat oxygen induced retinopathy (OIR) models, respectively^[2].

IC 50

KDR: 7 nM (IC₅₀)

References

[1] Fang YQ, et al. Efficient syntheses of KDR kinase inhibitors using a Pd-catalyzed tandem C-N/Suzuki coupling as the key step. J Org Chem. 2007 Feb 16;72(4):1341-6. DOI:10.1021/jo062228w
[2] Kinose F, et al. Inhibition of retinal and choroidal neovascularization by a novel KDR kinase inhibitor. Molecular Vision 2005; 11:366-373

3-[5-[2-[(2-Methoxyethyl)methylamino]ethoxy]-1H-indol-2-yl]-2(1H)-quinolinone Preparation Products And Raw materials

Raw materials

Preparation Products

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3-[5-[2-[(2-Methoxyethyl)methylamino]ethoxy]-1H-indol-2-yl]-2(1H)-quinolinone Suppliers

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408502-06-7, 3-[5-[2-[(2-Methoxyethyl)methylamino]ethoxy]-1H-indol-2-yl]-2(1H)-quinolinoneRelated Search:

2,4-PyriMidinediaMine with linker N-(4-CHLOROPHENYL)-2-[(PYRIDIN-4-YLMETHYL)AMINO]BENZAMIDE 3-nitro-N-(8-quinolinyl)benzamide 3'-[(5,6,7,8-Tetrahydro[1]benzothieno[2,3-d]pyrimidine-4-yl)oxy]acetophenone

3-[5-[2-[(2-Methoxyethyl)methylamino]ethoxy]-1H-indol-2-yl]-2(1H)-quinolinone

KDR-in-4

2(1H)-Quinolinone, 3-[5-[2-[(2-methoxyethyl)methylamino]ethoxy]-1H-indol-2-yl]-

VEGFR-2-IN-9

VEGFR 2 IN 9,VEGFR2IN9

408502-06-7