Carteolol hydrochloride

ChemicalBook > CAS DataBase List > Carteolol hydrochloride

Carteolol hydrochloride

Product Name: Carteolol hydrochloride
CAS No.: 51781-21-6
Chemical Name: Carteolol hydrochloride
Synonyms: endak;oc1085;Tenalet;Cartrol;Carteol;Teoptic;Cartelo;mikelan;opc1085;Cartelol
CBNumber: CB6335371
Molecular Formula: C16H25ClN2O3
Formula Weight: 328.83
MOL File: 51781-21-6.mol

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Carteolol hydrochloride Property

Melting point:: 278°C
storage temp.: Refrigerator
solubility: Soluble in water, sparingly soluble in methanol, slightly soluble in ethanol 96 per cent, practically insoluble in methylene chloride.
form: Solid
color: White to Off-White
Merck: 14,1866

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Safety

RTECS: VC8282000
HS Code: 2933790002
Toxicity: LD50 in male mice, rats (mg/kg): 810, 1380 orally; 54.5, 158 i.v.; 380, 400 i.p. (Lang)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y0000193
Product name: Carteolol for system suitability
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: y0000193
Price: $150
Updated: 2024/03/01

Sigma-Aldrich

Product number: BP567
Product name: Carteolol hydrochloride
Purity: British Pharmacopoeia (BP) Reference Standard
Packaging: 100MG
Price: $208
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1096757
Product name: Carteolol for system suitability
Packaging: 200mg
Price: $416
Updated: 2024/03/01

Cayman Chemical

Product number: 23758
Product name: Carteolol (hydrochloride)
Purity: ≥98%
Packaging: 25mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 23758
Product name: Carteolol (hydrochloride)
Purity: ≥98%
Packaging: 50mg
Price: $121
Updated: 2024/03/01

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Carteolol hydrochloride Chemical Properties,Usage,Production

Chemical Properties

Crystalline Solid

Uses

β-Adrenergic blocker. Antihypertensive; antianginal; antiarrhythmic; antiglaucoma.

brand name

Cartrol (Abbott); Ocupress (Novartis).

Biological Activity

beta-adrenergic antagonist are an important class of drugs for the treatment of various heart diseases, such as high blood pressure, insufficiency of blood flow to the heart muscle, irregular heart beat, thickened heart muscle, and decreased ability of the heart to empty or fill normally. β-blockers can also be used to treat migraine headache and increased eye pressure (glaucoma). carteolol is a nonselective beta-adrenoceptor antagonist.

Pharmacology

Carteolol hydrochloride is a powerful beta-adrenergic receptor antagonist characterized by a long-term pharmacological action, the lack of beta receptor selectivity, an intrinsic sympathomimetic activity (ISA), and a slight local anaesthetic activity (approximately 1/10 of that of propranolol). This drug has a dose-dependent hypotensive effect and does not engender the onset of tachyphylaxis. The pharmacological action consists in the decreased formation of aqueous humor, probably by acting at the level of the ciliary body presenting a wealth of ?2 receptors. The intrinsic sympathomimetic activity of carteolol is responsible for the low incidence of side effects and, thus, for maintaining the heart rate, pulse rate, and arterial blood pressure within the normal physiological range.

Pharmacokinetics

The instillation of carteolol hydrochloride is followed by the rapid absorption by the ocular tissues. Following the instillation of 10μl of 14C-carteolol ophthalmic solution 20 mg/ml into rabbit eyes, the highest platelet and tissue concentrations were obtained between 30 minutes to 2 hours. The study shows that, following topical application, carteolol spreads rapidly into the ocular tissues, passing the corneal barrier. The highest concentrations of 14C-carteolol were found in the following ocular tissues: cornea, iris, anterior sclera, ciliary body conjunctiva, and extraocular muscle. Slightly lower concentrations were found in the retina, choroid, posterior sclera, optic nerve, and aqueous humor. The concentration was especially low in the lens, vitreous body, and plasma. In the various tissues of the contralateral eye, very low radioactivity levels were measured. After the instillation of one drop of carteolol ophthalmic solution 20 mg/ml in healthy volunteers, the plasma concentrations were negligible (1-2 ng/ml). Approximately 16% of the dose is excreted in the urine as an unchanged compound during the first 24 hours after the instillation of a single drop of carteolol hydrochloride 20 mg/ml. The urinary elimination half-life following topical application is about 5 hours.

Clinical Use

The chemical name for carteolol hydrochloride (carteolol) is (±)-5-[3-[(1,1-dimethyl ethyl) amino]-2-hydroxypropoxy]-3,4-dihydro-2(1H)-quinolinone monohydrochloride. Carteolol Hydrochloride (carteolol) Ophthalmic Solution USP, 1% is a nonselective beta-adrenoceptor blocking agent for ophthalmic use. Each mL of sterile solution contains Active: carteolol hydrochloride (carteolol) 10 mg (1%). This drug is used to treat open-angle glaucoma and other causes of high pressure inside the eye. Carteolol hydrochloride ophthalmic may interact with oral carteolol, digoxin, reserpine, insulin or oral diabetes medications, other beta-blockers, calcium channel blockers, or medicines to treat psychiatric disorders.

in vitro

previous findings demonstrate that carteolol, unlike xamoterol, is a nonconventional partial agonist, which causes agonistic effects via interaction with the low-affinity propranolol-resistant site of β1-adrenoceptors and antagonistic actions by the high-affinity site of the same receptors [1].

in vivo

both 8-oh carteolol and carteolol suppressed the water-load induced intraocular pressure (iop) rise in rabbits. 8-oh carteolol was more effective in suppressing water-load induced iop rise in rabbits compared with carteolol on equimolar basis. both 8-oh carteololand carteolol caused a significant decrease in iop in monkeys. 8-oh carteolol was estimated to be more potent than carteolol in lowering iop on equimolar basis in monkeys [2].

References

[1] maura floreani, guglielmina froldi, luigi quintieri, katia varani, pier andrea borea, maria teresa dorigo and paola dorigo. in vitro evidence that carteolol is a nonconventional partial agonist of guinea pig cardiac β1-adrenoceptors: a comparison with xamoterol. jpet 315:1386–1395, 2005
[2] sugiyama k, enya t, kitazawa y. ocular hypotensive effect of 8-hydroxycarteolol, a metabolite of carteolol. int ophthalmol. 1989 jan;13(1-2):85-9.
[3] trinquand c, romanet jp, nordmann jp, allaire c; groupe d'étude. efficacy and safety of long-acting carteolol 1% once daily. a double-masked, randomized study. j fr ophtalmol. 2003 feb;26(2):131-6.

Carteolol hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Carteolol hydrochloride manufacturers

Zibo Hangyu Biotechnology Development Co., Ltd

Product: Carteolol hydrochloride 51781-21-6
Price: US $80.00-800.00/KG
Min. Order: 1KG
Purity: 0.99
Supply Ability: 20 tons
Release date: 2023-10-20

Zhuozhou Wenxi import and Export Co., Ltd

Product: Carteolol hydrochloride 51781-21-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Carteolol hydrochloride 51781-21-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

51781-21-6, Carteolol hydrochlorideRelated Search:

Timolol Tobramycin Betaxolol hydrochloride Clenbuterol hydrochloride Brinzolamide D-Timolol maleate 2'-Methyl-3'-methoxyacetanilide N1-[3-(3-AMINOPROPOXY)PHENYL]ACETAMIDE Carteolol Carteolol hydrochloride 5-METHOXY-3,4-DIHYDRO-1H-QUINOLIN-2-ONE 5-METHOXY-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE 5-Hydroxy-3,4-dihydroquinolin-2(1H)-one Dihydroalprenolol 2-Methyl-3-methoxyaniline hydrochloride 2(1H)-Quinolinone, 5-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-3,4-dihydro-, monohydrochloride, (R)- 2(1H)-Quinolinone, 5-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-3,4-dihydro-, monohydrochloride, (S)- 4-PROPOXYACETANILINE

CARTEOLOL (HYDROCHLORIDE);NSC 300906;OPC 1085

5-[3-[(1,1-Dimethylethyl)amino]-2-hydroxypropoxy]-3,4-dihydro-2(1H)-quinolinone Hydrochloride

5-[3-[(tert-butyl)amino]-2-hydroxypropoxy]-3,4-dihydro-2-quinolone monohydrochloride

Arteoptic

Caltidren

Carteol

Cartrol

dl-Carteolol hydrochloride

NSC 300906

Optipress

Tenalet

Teoptic

Cartelo

Cartelol

Carteolol T

Orukalol

Carteolol Hydrochloride (200 mg)

Ocupress

2(1H)-Quinolinone,5-[3-[(1,1-diMethylethyl)aMino]-2-hydroxypropoxy]-3,4-dihydro-, hydrochloride(1:1)

5-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-3,4-dihydro-2(1H)-quinolinone,hydrochloride (1:1)

Carteolol monohydrochloride

5-(2-hydroxy-3-tert-butylamino)propoxy-3,4-dihydrocarbostyrilhydrochloride

5-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy)-3,4-dihydro-2(1h)-quinolin

5-(3-tert-butylamino-2-hydroxy)propoxy-3,4-dihydrocarbostyrilhydrochloride

5-(3-tert-butylamino-2-hydroxy-propoxy)-3,4-dihydro-2(1h)-chinolinon-hydroch

abbott-43326

carbonolol

carteololhydrochloride

endak

endakmite

mikelan

oc1085

opc1085

2(1H)-QUINOLINONE, 5-[3-[(1,1-DIMETHYLETHYL)AMINO]-2-HYDROXYPROPOXY]-3,4-DIHYDRO-, MONOHYDROCHLORIDE

carteolol HCl

Carteolol for system suitability CRS

OPC-1085 hydrochloride

5-[(2RS)-3-[(1,1-Dimethylethyl)amino]-2-hydroxypropoxy]- 3,4-dihydroquinolin-2(1H)-one hydrochloride

Carteolol hydrochloride USP/EP/BP

Carteolol HCl (OPC-1085 HCl)

2(1H)-QUINOLINONE, 5-[3-[(1,1-DIMETHYLETHYL)AMINO]-2-HYDROXYPROPOXY]-3,4-DIHYDRO-, MONOHYDROCHLORIDE 51781-21-6

Carteolol Hydrochloride (1096757)

Carteolol Hydrochloride CAS NO.51781-21-6

Carteolol hydrochloride, 10 mM in DMSO

51781-21-6

C16H25ClN2O3

C16H24N2O3HCl

32883

API

CARTROL

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